Gene description for PLD1
Gene name
phospholipase D1, phosphatidylcholine-specific
Gene symbol
PLD1
Other names/aliases
-
Species
Homo sapiens
Database cross references - PLD1
ExoCarta
ExoCarta_5337
Entrez Gene
5337
HGNC
9067
MIM
602382
UniProt
Q13393
PLD1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells
23333927
Ovarian cancer cells
23333927
Gene ontology annotations for PLD1
Experiment description of studies that identified PLD1 in exosomes
1
Experiment ID
211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
IGROV1
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
2
Experiment ID
212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
OVCAR-3
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for PLD1
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
PIP5K1A
8394
Invivo
Homo sapiens
2
CDC42
998
Invitro
Homo sapiens
Invivo
Homo sapiens
3
SNCA
6622
Reconstituted Complex
Homo sapiens
Affinity Capture-Western
Homo sapiens
4
PKN1
Reconstituted Complex
Homo sapiens
Affinity Capture-Western
Homo sapiens
5
SRC
6714
Biochemical Activity
Homo sapiens
6
RAC1
5879
Invivo
Homo sapiens
7
Actb
81822
Reconstituted Complex
Rattus norvegicus
8
PEA15
Reconstituted Complex
Homo sapiens
Two-hybrid
Homo sapiens
Affinity Capture-Western
Homo sapiens
9
AMPH
Reconstituted Complex
Homo sapiens
Phenotypic Suppression
Homo sapiens
Affinity Capture-Western
Homo sapiens
10
RALA
5898
Reconstituted Complex
Homo sapiens
11
RHOA
387
Biochemical Activity
Homo sapiens
Reconstituted Complex
Homo sapiens
Affinity Capture-Western
Homo sapiens
Reconstituted Complex
Homo sapiens
12
ARF6
382
Invivo
Homo sapiens
13
BIN1
274
Reconstituted Complex
Homo sapiens
Phenotypic Suppression
Homo sapiens
14
PRKCA
5578
Affinity Capture-Western
Homo sapiens
15
ARF1
375
Invitro
Homo sapiens
Invivo
Homo sapiens
View the network
image/svg+xml
Pathways in which PLD1 is involved