Gene description for HIF1A
Gene name	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Gene symbol	HIF1A
Other names/aliases	HIF-1A HIF-1alpha HIF1 HIF1-ALPHA MOP1 PASD8 bHLHe78
Species	Homo sapiens
Database cross references - HIF1A
ExoCarta	ExoCarta_3091
Vesiclepedia	VP_3091
Entrez Gene	3091
HGNC	4910
MIM	603348
UniProt	Q16665
HIF1A identified in exosomes derived from the following tissue/cell type
Kidney cancer cells	35333565
Retinal pigment epithelial cells	35333565

Gene ontology annotations for HIF1A

Molecular Function     protein binding GO:0005515 IPI     sequence-specific DNA binding GO:0043565 IDA     signal transducer activity GO:0004871 IEA     histone acetyltransferase binding GO:0035035 IPI     transcription factor binding GO:0008134 IPI     sequence-specific DNA binding transcription factor activity GO:0003700 TAS     ubiquitin protein ligase binding GO:0031625 IPI     RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity GO:0003705 IDA     transcription factor binding transcription factor activity GO:0000989 IDA     Hsp90 protein binding GO:0051879 IDA     protein heterodimerization activity GO:0046982 TAS     RNA polymerase II transcription factor binding transcription factor activity GO:0001076 IEA     RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IEA     histone deacetylase binding GO:0042826 IEA     enzyme binding GO:0019899 IPI     nuclear hormone receptor binding GO:0035257 IPI     protein kinase binding GO:0019901 IPI Biological Process     positive regulation of nitric-oxide synthase activity GO:0051000 TAS     B-1 B cell homeostasis GO:0001922 IEA     heart looping GO:0001947 IEA     positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IEA     negative regulation of TOR signaling GO:0032007 IEA     regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 TAS     embryonic placenta development GO:0001892 IEA     regulation of gene expression GO:0010468 IDA     glucose homeostasis GO:0042593 IEA     positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 IMP     neural crest cell migration GO:0001755 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IGI     cartilage development GO:0051216 IEA     signal transduction GO:0007165 IMP     negative regulation of bone mineralization GO:0030502 IEA     intestinal epithelial cell maturation GO:0060574 IEA     positive regulation of hormone biosynthetic process GO:0046886 IDA     cellular response to interleukin-1 GO:0071347 IEP     collagen metabolic process GO:0032963 ISS     positive regulation of endothelial cell proliferation GO:0001938 IC     regulation of transcription, DNA-templated GO:0006355 IDA     cellular response to hypoxia GO:0071456 TAS     cellular iron ion homeostasis GO:0006879 IEA     positive regulation of epithelial cell migration GO:0010634 ISS     positive regulation of receptor biosynthetic process GO:0010870 IMP     positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 IC     mRNA transcription from RNA polymerase II promoter GO:0042789 IC     epithelial cell differentiation involved in mammary gland alveolus development GO:0061030 IEA     positive regulation of angiogenesis GO:0045766 IC     epithelial to mesenchymal transition GO:0001837 ISS     digestive tract morphogenesis GO:0048546 IEA     regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0043619 IDA     hemoglobin biosynthetic process GO:0042541 IEA     response to muscle activity GO:0014850 IEA     positive regulation of neuroblast proliferation GO:0002052 IEA     retina vasculature development in camera-type eye GO:0061298 IEA     cardiac ventricle morphogenesis GO:0003208 IEA     negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 IDA     positive regulation of chemokine-mediated signaling pathway GO:0070101 IC     positive regulation of glycolytic process GO:0045821 IC     response to hypoxia GO:0001666 IMP     elastin metabolic process GO:0051541 ISS     negative regulation of mesenchymal cell apoptotic process GO:2001054 IEA     positive regulation of vascular endothelial growth factor production GO:0010575 IMP     angiogenesis GO:0001525 IEA     negative regulation of thymocyte apoptotic process GO:0070244 IEA     cerebral cortex development GO:0021987 IEA     oxygen homeostasis GO:0032364 IDA     neural fold elevation formation GO:0021502 IEA     negative regulation of growth GO:0045926 IEA     axon transport of mitochondrion GO:0019896 IMP     outflow tract morphogenesis GO:0003151 IEA     visual learning GO:0008542 IEA     positive regulation of transcription, DNA-templated GO:0045893 IMP     vascular endothelial growth factor production GO:0010573 IDA     muscle cell cellular homeostasis GO:0046716 IEA     positive regulation of chemokine production GO:0032722 TAS     Notch signaling pathway GO:0007219 TAS     embryonic hemopoiesis GO:0035162 IEA     regulation of transforming growth factor beta2 production GO:0032909 IMP     positive regulation of erythrocyte differentiation GO:0045648 IC     lactate metabolic process GO:0006089 IEA     connective tissue replacement involved in inflammatory response wound healing GO:0002248 ISS     dopaminergic neuron differentiation GO:0071542 IEA     lactation GO:0007595 IEA Subcellular Localization     RNA polymerase II transcription factor complex GO:0090575 IDA     nucleolus GO:0005730 IDA     nuclear speck GO:0016607 ISS     motile cilium GO:0031514 IEA     nucleus GO:0005634 IDA     cytosol GO:0005829 TAS     transcription factor complex GO:0005667 IPI     cytoplasm GO:0005737 IDA     nucleoplasm GO:0005654 TAS