Gene description for HEATR1
Gene name HEAT repeat containing 1
Gene symbol HEATR1
Other names/aliases BAP28
UTP10
Species Homo sapiens
 Database cross references - HEATR1
ExoCarta ExoCarta_55127
Entrez Gene 55127
HGNC 25517
UniProt Q9H583  
 HEATR1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for HEATR1
Molecular Function
    snoRNA binding GO:0030515 IBA
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of transcription from RNA polymerase I promoter GO:0045943 IBA
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000462 IBA
Subcellular Localization
    nucleolus GO:0005730 IDA
    mitochondrion GO:0005739 IDA
    membrane GO:0016020 IDA
    nucleus GO:0005634 IDA
    t-UTP complex GO:0034455 IBA
    small-subunit processome GO:0032040 IBA
    90S preribosome GO:0030686 IBA
 Experiment description of studies that identified HEATR1 in exosomes
1
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for HEATR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAGED1  
Affinity Capture-MS Homo sapiens
2 ILK 3611
Affinity Capture-MS Homo sapiens
3 PTP4A3  
Affinity Capture-MS Homo sapiens
4 TTBK1  
Affinity Capture-MS Homo sapiens
5 MYC  
Affinity Capture-MS Homo sapiens
6 PELO 53918
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HEATR1 is involved
No pathways found





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