Gene description for ARHGEF39
Gene name Rho guanine nucleotide exchange factor (GEF) 39
Gene symbol ARHGEF39
Other names/aliases C9orf100
Species Homo sapiens
 Database cross references - ARHGEF39
ExoCarta ExoCarta_84904
Entrez Gene 84904
HGNC 25909
UniProt Q8N4T4  
 ARHGEF39 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ARHGEF39
Molecular Function
    protein binding GO:0005515 IPI
    Rho guanyl-nucleotide exchange factor activity GO:0005089 IEA
Biological Process
    positive regulation of cell migration GO:0030335 IDA
    positive regulation of GTPase activity GO:0043547 IEA
Subcellular Localization
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified ARHGEF39 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ARHGEF39
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RBPMS  
Two-hybrid Homo sapiens
2 DVL2 1856
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ARHGEF39 is involved
No pathways found





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