Gene description for SSB
Gene name Sjogren syndrome antigen B (autoantigen La)
Gene symbol SSB
Other names/aliases LARP3
La
La/SSB
Species Homo sapiens
 Database cross references - SSB
ExoCarta ExoCarta_6741
Entrez Gene 6741
HGNC 11316
MIM 109090
UniProt P05455  
 SSB identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SSB
Molecular Function
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
    tRNA binding GO:0000049 TAS
    mRNA binding GO:0003729 TAS
    nucleotide binding GO:0000166 IEA
Biological Process
    histone mRNA metabolic process GO:0008334 TAS
    tRNA modification GO:0006400 TAS
Subcellular Localization
    nucleus GO:0005634 IEA
    ribonucleoprotein complex GO:0030529 IEA
 Experiment description of studies that identified SSB in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SSB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NCL 4691
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
2 PUF60 22827
Affinity Capture-MS Homo sapiens
3 PMVK 10654
Affinity Capture-MS Homo sapiens
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