Gene description for IFIT5
Gene name interferon-induced protein with tetratricopeptide repeats 5
Gene symbol IFIT5
Other names/aliases ISG58
P58
RI58
Species Homo sapiens
 Database cross references - IFIT5
ExoCarta ExoCarta_24138
Vesiclepedia VP_24138
Entrez Gene 24138
HGNC 13328
MIM 616135
UniProt Q13325  
 IFIT5 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for IFIT5
Molecular Function
    tRNA binding GO:0000049 IDA
    poly(A) RNA binding GO:0044822 IDA
    RNA binding GO:0003723 IDA
    single-stranded RNA binding GO:0003727 IDA
Biological Process
    defense response to virus GO:0051607 IMP
    innate immune response GO:0045087 IEA
Subcellular Localization
    apical part of cell GO:0045177 IDA
    ruffle membrane GO:0032587 IDA
    actin cytoskeleton GO:0015629 IDA
 Experiment description of studies that identified IFIT5 in exosomes
1
Experiment ID 488
MISEV standards
EM
EV Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
CANX
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 217
MISEV standards
EM
EV Biophysical techniques
TSG101|CD81|CD9|CD63
EV Enriched markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IFIT5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which IFIT5 is involved
No pathways found





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