Gene ontology annotations for RECQL  
                                                                    
                                                                        
                                                                            
                                                                                
                                                                         
                                                                     
                                                            
                                                            
                                                         
                                                        
                                                        
                                                            
                                                                  Experiment description  of studies that identified RECQL  in sEVs 
                                                                
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            1 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        489 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                Canx
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            36408942
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Rattus norvegicus 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Proteomics 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2023 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Bone marrow mesenchymal stem cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        BMSC - Passage 6 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting Mass spectometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            2 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        490 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                Canx
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            36408942
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Rattus norvegicus 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Proteomics 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2023 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Bone marrow mesenchymal stem cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        BMSC - Passage 7 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting Mass spectometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            3 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        491 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                Canx
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            36408942
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Rattus norvegicus 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Proteomics 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2023 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Bone marrow mesenchymal stem cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        BMSC - Passage 8 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting Mass spectometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            4 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        492 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                Canx
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            36408942
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Rattus norvegicus 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Proteomics 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2023 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Bone marrow mesenchymal stem cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        BMSC - Passage 9 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting Mass spectometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            5 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        412 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX|ACTB
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Breast cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        MCF7 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein mRNA 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR Western blotting Mass spectrometry Flow cytometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            6 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        414 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Breast cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        MDA-MB-231 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein mRNA 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR Western blotting Mass spectrometry Flow cytometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            7 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        426 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Breast cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        MDA-MB-231  - Exo-rich fractions 7-10 pooled 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation Size exclusion chromatography 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            8 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        427 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Breast cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        MDA-MB-231 - Exo-rich fractions 1-6 pooled 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation  
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            9 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        497 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            35931686
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Varela-EirÃÂn M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, GarcÃÂa-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Cell Death Dis 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2022 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Chondrocytes 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        T/C-28a2 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting Mass spectometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            10 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        498 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            35931686
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Varela-EirÃÂn M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, GarcÃÂa-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Cell Death Dis 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2022 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Chondrocytes 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        T/C-28a2 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting Mass spectometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            11 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        207 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                TSG101|HSP70|FLOT1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                VDAC
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            protein
                                                                                                                                                                                                                                     
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            23161513
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Mol Cell Proteomics 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2012 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Colorectal cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        DKO-1 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            12 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        208 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                TSG101|HSP70|FLOT1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                VDAC
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            protein
                                                                                                                                                                                                                                     
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            23161513
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Mol Cell Proteomics 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2012 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Colorectal cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        Dks-8 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            13 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        209 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                TSG101|HSP70|FLOT1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                VDAC
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            protein
                                                                                                                                                                                                                                     
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            23161513
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Mol Cell Proteomics 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2012 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Colorectal cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        DLD-1 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            14 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        407 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Embryonic kidney cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        HEK293T 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein mRNA 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR Western blotting Mass spectrometry Flow cytometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            15 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        419 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Embryonic kidney cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        HEK293T - Exo-rich fractions 7-10 pooled 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation Size exclusion chromatography 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            16 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        419 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Embryonic kidney cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        HEK293T - Exo-rich fractions 7-10 pooled 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation Size exclusion chromatography 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            17 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        420 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Embryonic kidney cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        HEK293T - Exo-rich fractions 1-6 pooled 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation  
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            18 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        420 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Embryonic kidney cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        HEK293T - Exo-rich fractions 1-6 pooled 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation  
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            19 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        1275 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD9|TSG101|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            36706192
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles  
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Sci Adv 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2023 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Embryonic kidney cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        HEK293T 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            20 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        1280 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                TSG101|CD9|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            36706192
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles  
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Sci Adv 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2023 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Embryonic kidney cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        HEK293T - Fraction 5 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        1.151 g/mL
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            21 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        405 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Foreskin fibroblasts 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        BJ  
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein mRNA 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR Western blotting Mass spectrometry Flow cytometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            22 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        363 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                DCLK1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            33991177
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Proteomics 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Gastric cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        MKN1 - 100K pellet 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            23 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        364 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                DCLK1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            33991177
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Proteomics 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Gastric cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        MKN1 - 100K pellet 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            24 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        365 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                DCLK1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            33991177
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Proteomics 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Gastric cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        MKN1 - 100K pellet 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            25 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        417 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX|ACTB
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Lymphoma cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        Raji 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein mRNA 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR Western blotting Mass spectrometry Flow cytometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            26 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        411 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Mammary cancer-associated fibroblasts 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        mCAF 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein mRNA 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR Western blotting Mass spectrometry Flow cytometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            27 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        488 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            36408942
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Proteomics 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2023 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Mesenchymal stem cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        UCMSC 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting Mass spectometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            28 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        418 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Monocytic leukemia cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        THP-1 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein mRNA 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR Western blotting Mass spectrometry Flow cytometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            29 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        418 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Monocytic leukemia cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        THP-1 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein mRNA 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR Western blotting Mass spectrometry Flow cytometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            30 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        413 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Normal mammary epithelial cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        MCF10A 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein mRNA 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR Western blotting Mass spectrometry Flow cytometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            31 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        211 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                TSG101|Alix|EpCAM|TFRC
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                cytochrome c|GOLGA2
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            protein
                                                                                                                                                                                                                                     
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            23333927
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Characterization and proteomic analysis of ovarian cancer-derived exosomes. 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            J Proteomics 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2013 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Ovarian cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        IGROV1 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Ultracentrifugation Sucrose density gradient 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        1.09-1.15 g/mL
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            32 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        212 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CEM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                TSG101|Alix|EpCAM|TFRC
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                Cytochrome C|GOLGA2
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            protein
                                                                                                                                                                                                                                     
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            23333927
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Characterization and proteomic analysis of ovarian cancer-derived exosomes. 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            J Proteomics 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2013 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Ovarian cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        OVCAR-3 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Ultracentrifugation Sucrose density gradient 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        1.09-1.15 g/mL
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            33 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        406 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Pancreatic cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        BxPC3 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein mRNA 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR Western blotting Mass spectrometry Flow cytometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            34 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        415 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Pancreatic cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        PANC-1 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein mRNA 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR Western blotting Mass spectrometry Flow cytometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            35 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        434 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Pancreatic cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        PANC-1  - Exo-rich fractions 7-10 pooled 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation Size exclusion chromatography 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            36 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        435 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Pancreatic cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        PANC-1 - Exo-rich fractions 1-6 pooled 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation OptiPrep density gradient centrifugation  
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            37 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        408 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX|ACTB
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Pancreatic duct epithalial cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        HPDE 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein mRNA 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR Western blotting Mass spectrometry Flow cytometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            38 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        409 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Pancreatic duct epithalial cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        HPNE 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein mRNA 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR Western blotting Mass spectrometry Flow cytometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            39 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        416 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Pluripotent stem cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        PSC 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein mRNA 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR Western blotting Mass spectrometry Flow cytometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            40 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        410 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        T lymphocytes 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        Jurkat 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein mRNA 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR Western blotting Mass spectrometry Flow cytometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            41 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        217 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                TSG101|CD81|CD9|CD63
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            protein
                                                                                                                                                                                                                                     
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            23844026
                                                                                                                        
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Characterization of human thymic exosomes. 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            PLoS One 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2013 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Thymus 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        Normal-Thymus 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation Filtration Ultracentrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                
                                                         
                                                        
                                                        
                                                        
                                                            
                                                                
                                                                    
                                                                        
                                                                              Protein-protein interactions for RECQL  
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                              
                                                                                            Protein Interactor 
                                                                                            ExoCarta ID 
                                                                                            Identification method 
                                                                                            PubMed 
                                                                                            Species 
                                                                                         
                                                                                                                                                                                    
                                                                                                
                                                                                                    1 
                                                                                                                                                                                                                UBE2H 
                                                                                                            7328  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    2 
                                                                                                                                                                                                                HIST2H2BE 
                                                                                                            8349  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    3 
                                                                                                                                                                                                                WIF1 
                                                                                                            11197  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    4 
                                                                                                                                                                                                            FOXA1 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    5 
                                                                                                                                                                                                                PLEKHA4 
                                                                                                            57664  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    6 
                                                                                                                                                                                                            GRPEL2 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Co-fractionation 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    7 
                                                                                                                                                                                                            HOXA2 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    8 
                                                                                                                                                                                                                TOMM34 
                                                                                                            10953  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Co-fractionation 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    9 
                                                                                                                                                                                                                KIF14 
                                                                                                            9928  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    10 
                                                                                                                                                                                                            BKRF1 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                     
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    11 
                                                                                                                                                                                                                RBPJ 
                                                                                                            3516  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    12 
                                                                                                                                                                                                            MAX 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    13 
                                                                                                                                                                                                                MSH2 
                                                                                                            4436  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Co-fractionation 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    14 
                                                                                                                                                                                                                FEN1 
                                                                                                            2237  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Co-fractionation 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    15 
                                                                                                                                                                                                            SIRT7 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    16 
                                                                                                                                                                                                                TXNRD2 
                                                                                                            10587  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Co-fractionation 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    17 
                                                                                                                                                                                                                NFATC1 
                                                                                                            4772  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    18 
                                                                                                                                                                                                                HIST1H2BG 
                                                                                                            8339  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Proximity Label-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    19 
                                                                                                                                                                                                            HOXB2 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    20 
                                                                                                                                                                                                            FOXO1 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    21 
                                                                                                                                                                                                                HIST1H1E 
                                                                                                            3008  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Cross-Linking-MS (XL-MS) 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    22 
                                                                                                                                                                                                                GOLT1B 
                                                                                                            51026  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    23 
                                                                                                                                                                                                            FOXC1 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                        Affinity Capture-MS 
                                                                                                                                         
                                                                                                                                        Homo sapiens 
                                                                                                                                                                                                                                                             
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    24 
                                                                                                                                                                                                                RPL35A 
                                                                                                            6165  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    25 
                                                                                                                                                                                                            NTNG1 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    26 
                                                                                                                                                                                                                KPNA4 
                                                                                                            3840  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                        Two-hybrid 
                                                                                                                                         
                                                                                                                                        Homo sapiens 
                                                                                                                                                                                                                                                             
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Reconstituted Complex 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    27 
                                                                                                                                                                                                                UBC 
                                                                                                            7316  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Reconstituted Complex 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    28 
                                                                                                                                                                                                            CYP1A1 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                        Affinity Capture-MS 
                                                                                                                                         
                                                                                                                                        Homo sapiens 
                                                                                                                                                                                                                                                             
                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                        Affinity Capture-MS 
                                                                                                                                         
                                                                                                                                        Homo sapiens 
                                                                                                                                                                                                                                                             
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    29 
                                                                                                                                                                                                                KPNA2 
                                                                                                            3838  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                        Two-hybrid 
                                                                                                                                         
                                                                                                                                        Homo sapiens 
                                                                                                                                                                                                                                                             
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Reconstituted Complex 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    30 
                                                                                                                                                                                                            FOXI2 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    31 
                                                                                                                                                                                                            SCHIP1 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    32 
                                                                                                                                                                                                                HNRNPA1 
                                                                                                            3178  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Cross-Linking-MS (XL-MS) 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    33 
                                                                                                                                                                                                            FAM35A 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Proximity Label-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    34 
                                                                                                                                                                                                            CREB1 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    35 
                                                                                                                                                                                                                TP53 
                                                                                                            7157  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    36 
                                                                                                                                                                                                                MTPN 
                                                                                                            136319  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    37 
                                                                                                                                                                                                                DNAJB6 
                                                                                                            10049  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    38 
                                                                                                                                                                                                                MVK 
                                                                                                            4598  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Co-fractionation 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    39 
                                                                                                                                                                                                            HOXC5 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    40 
                                                                                                                                                                                                            PARK2 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    41 
                                                                                                                                                                                                                PCBP1 
                                                                                                            5093  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    42 
                                                                                                                                                                                                                USP47 
                                                                                                            55031  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                        Affinity Capture-MS 
                                                                                                                                         
                                                                                                                                        Homo sapiens 
                                                                                                                                                                                                                                                             
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    43 
                                                                                                                                                                                                                RTCB 
                                                                                                            51493  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Co-fractionation 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    44 
                                                                                                                                                                                                                NTRK1 
                                                                                                            4914  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    45 
                                                                                                                                                                                                                PLS3 
                                                                                                            5358  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Co-fractionation 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    46 
                                                                                                                                                                                                            CENPM 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    47 
                                                                                                                                                                                                                CIT 
                                                                                                            11113  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    48 
                                                                                                                                                                                                                SYNCRIP 
                                                                                                            10492  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    49 
                                                                                                                                                                                                            TEAD2 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    50 
                                                                                                                                                                                                                PARP1 
                                                                                                            142  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    51 
                                                                                                                                                                                                                PSMC5 
                                                                                                            5705  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                        Affinity Capture-MS 
                                                                                                                                         
                                                                                                                                        Homo sapiens 
                                                                                                                                                                                                                                                             
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    52 
                                                                                                                                                                                                                BANF1 
                                                                                                            8815  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    53 
                                                                                                                                                                                                                DDB1 
                                                                                                            1642  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                        Affinity Capture-Western 
                                                                                                                                         
                                                                                                                                        Homo sapiens 
                                                                                                                                                                                                                                                             
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-Western 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    54 
                                                                                                                                                                                                                EVA1B 
                                                                                                            55194  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    55 
                                                                                                                                                                                                            SCRT2 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    56 
                                                                                                                                                                                                                PML 
                                                                                                            5371  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    57 
                                                                                                                                                                                                            SNRNP27 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                        Affinity Capture-MS 
                                                                                                                                         
                                                                                                                                        Homo sapiens 
                                                                                                                                                                                                                                                             
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    58 
                                                                                                                                                                                                                MAP7 
                                                                                                            9053  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Co-fractionation 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    59 
                                                                                                                                                                                                            RABIF 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    60 
                                                                                                                                                                                                            FOXE1 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    61 
                                                                                                                                                                                                                RPA3 
                                                                                                            6119  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Proximity Label-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    62 
                                                                                                                                                                                                            CEBPA 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Protein-peptide 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    63 
                                                                                                                                                                                                            MDM2 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    64 
                                                                                                                                                                                                            NEIL3 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Protein-RNA 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    65 
                                                                                                                                                                                                                IFIT5 
                                                                                                            24138  
                                                                                                    
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Co-fractionation 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    66 
                                                                                                                                                                                                            RBM10 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Cross-Linking-MS (XL-MS) 
                                                                                                                                     
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                                                                                                                
                                                                                                    
                                                                                                        View the network 
                                                                                                     
                                                                                                    
                                                                                                        
                                                                                                                    
                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                            image/svg+xml 
                                                                                                                             
                                                                                                                             
                                                                                                                             
                                                                                                                         
                                                                                                                         
                                                                                                                         
                                                                                                                         
                                                                                                                         
                                                                                                                         
                                                                                                                         
                                                                                                                         
                                                                                                                         
                                                                                                                         
                                                                                                                         
                                                                                                                         
                                                                                                                     
                                                                                                         
                                                                                                     
                                                                                                 
                                                                                                                                                                            
                                                                                 
                                                                             
                                                            
                                                         
                                                        
                                                        
                                                        
                                                            
                                                                
                                                                    
                                                                          Pathways in which RECQL  is involved 
                                                                        
                                                                            
                                                                                                                                                                            No pathways found