Gene description for MVK
Gene name mevalonate kinase
Gene symbol MVK
Other names/aliases LRBP
MK
MVLK
POROK3
Species Homo sapiens
 Database cross references - MVK
ExoCarta ExoCarta_4598
Vesiclepedia VP_4598
Entrez Gene 4598
HGNC 7530
MIM 251170
UniProt Q03426  
 MVK identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for MVK
Molecular Function
    magnesium ion binding GO:0000287 ISS
    mevalonate kinase activity GO:0004496 IBA
    mevalonate kinase activity GO:0004496 IDA
    mevalonate kinase activity GO:0004496 IMP
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 ISS
    identical protein binding GO:0042802 IDA
    identical protein binding GO:0042802 IPI
Biological Process
    cholesterol biosynthetic process GO:0006695 IBA
    cholesterol biosynthetic process GO:0006695 IDA
    isoprenoid biosynthetic process GO:0008299 IDA
    isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287 IBA
    isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287 IEA
    negative regulation of inflammatory response GO:0050728 IMP
Subcellular Localization
    peroxisome GO:0005777 IDA
    peroxisome GO:0005777 ISS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified MVK in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MVK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ANLN 54443
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 PPP1CB 5500
Co-fractionation Homo sapiens
4 TRIM13  
Affinity Capture-MS Homo sapiens
5 RECQL 5965
Co-fractionation Homo sapiens
6 POT1  
Two-hybrid Homo sapiens
7 GSS 2937
Co-fractionation Homo sapiens
8 TRNT1 51095
Affinity Capture-MS Homo sapiens
9 CCDC91 55297
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 MAT1A 4143
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
11 RNF141  
Two-hybrid Homo sapiens
12 HOXB2  
Affinity Capture-MS Homo sapiens
13 ACAA2 10449
Affinity Capture-MS Homo sapiens
14 GMDS 2762
Co-fractionation Homo sapiens
15 C17orf75 64149
Affinity Capture-MS Homo sapiens
16 KHDRBS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 MVK 4598
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
18 SPACA4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 DDX58 23586
Affinity Capture-RNA Homo sapiens
20 NXF1 10482
Affinity Capture-RNA Homo sapiens
21 EPSTI1  
Affinity Capture-MS Homo sapiens
22 APEX1 328
Affinity Capture-RNA Homo sapiens
23 TERF1 7013
Two-hybrid Homo sapiens
24 RPA3 6119
Proximity Label-MS Homo sapiens
25 GGT5 2687
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 UBFD1 56061
Co-fractionation Homo sapiens
27 MOV10 4343
Affinity Capture-RNA Homo sapiens
28 RPA2 6118
Proximity Label-MS Homo sapiens
29 LPCAT2 54947
Affinity Capture-MS Homo sapiens
30 BACE2 25825
Affinity Capture-MS Homo sapiens
31 ANKRD49  
Affinity Capture-MS Homo sapiens
32 SLC22A23  
Affinity Capture-MS Homo sapiens
33 SERBP1 26135
Affinity Capture-MS Homo sapiens
34 NUDT3 11165
Co-fractionation Homo sapiens
35 KLHL10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 ENO1 2023
Affinity Capture-RNA Homo sapiens
37 KRAS 3845
Negative Genetic Homo sapiens
38 LEF1  
Affinity Capture-MS Homo sapiens
39 EWSR1 2130
Two-hybrid Homo sapiens
40 WARS 7453
Co-fractionation Homo sapiens
41 BMP4 652
Affinity Capture-MS Homo sapiens
42 CEBPA  
Protein-peptide Homo sapiens
43 DOC2A  
Affinity Capture-MS Homo sapiens
44 NAB1 4664
Affinity Capture-MS Homo sapiens
45 TACC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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