Gene description for BMP4
Gene name	bone morphogenetic protein 4
Gene symbol	BMP4
Other names/aliases	BMP2B BMP2B1 MCOPS6 OFC11 ZYME
Species	Homo sapiens
Database cross references - BMP4
ExoCarta	ExoCarta_652
Entrez Gene	652
HGNC	1071
MIM	112262
UniProt	P12644
BMP4 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513

Gene ontology annotations for BMP4

Molecular Function     chemoattractant activity GO:0042056 IDA     growth factor activity GO:0008083 IEA     transforming growth factor beta receptor binding GO:0005160 IBA     heparin binding GO:0008201 IEA     BMP receptor binding GO:0070700 IDA     cytokine activity GO:0005125 IDA     protein binding GO:0005515 IPI Biological Process     endocardial cushion development GO:0003197 TAS     cranial suture morphogenesis GO:0060363 IEA     odontogenesis GO:0042476 IGI     chondrocyte differentiation GO:0002062 ISS     epithelial-mesenchymal cell signaling GO:0060684 IEA     positive regulation of DNA-dependent DNA replication GO:2000105 IDA     negative regulation of apoptotic process GO:0043066 IDA     odontogenesis of dentin-containing tooth GO:0042475 IEA     negative regulation of cell proliferation involved in heart morphogenesis GO:2000137 IMP     lung morphogenesis GO:0060425 IDA     steroid hormone mediated signaling pathway GO:0043401 IMP     cardiac septum development GO:0003279 TAS     mesenchymal cell proliferation involved in ureteric bud development GO:0072138 IEA     activation of MAPKK activity GO:0000186 IDA     anterior/posterior axis specification GO:0009948 IEA     monocyte differentiation GO:0030224 IDA     renal system development GO:0072001 IEP     osteoblast differentiation GO:0001649 IDA     type B pancreatic cell development GO:0003323 IDA     pulmonary artery endothelial tube morphogenesis GO:0061155 IDA     kidney development GO:0001822 IMP     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     telencephalon regionalization GO:0021978 IEA     bronchus development GO:0060433 IDA     lymphoid progenitor cell differentiation GO:0002320 IMP     telencephalon development GO:0021537 IDA     negative regulation of thymocyte apoptotic process GO:0070244 IMP     tendon cell differentiation GO:0035990 ISS     negative regulation of T cell differentiation in thymus GO:0033085 IMP     smoothened signaling pathway GO:0007224 IEP     positive regulation of SMAD protein import into nucleus GO:0060391 IDA     bud elongation involved in lung branching GO:0060449 IEA     regulation of cell fate commitment GO:0010453 IDA     negative regulation of striated muscle tissue development GO:0045843 IDA     cellular response to growth factor stimulus GO:0071363 IEA     negative regulation of MAP kinase activity GO:0043407 IDA     specification of organ position GO:0010159 IEA     ureter smooth muscle cell differentiation GO:0072193 ISS     negative regulation of epithelial cell proliferation GO:0050680 IEA     positive regulation of branching involved in lung morphogenesis GO:0061047 ISS     regulation of branching involved in prostate gland morphogenesis GO:0060687 IEA     regulation of smooth muscle cell differentiation GO:0051150 IEA     negative regulation of branching involved in ureteric bud morphogenesis GO:0090191 IDA     glomerular capillary formation GO:0072104 ISS     positive regulation of ossification GO:0045778 IDA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA     lung alveolus development GO:0048286 IDA     regulation of protein import into nucleus GO:0042306 IDA     mesenchymal cell proliferation involved in ureter development GO:0072198 IEA     negative regulation of glomerular mesangial cell proliferation GO:0072125 IDA     negative regulation of cell cycle GO:0045786 IDA     branching morphogenesis of an epithelial tube GO:0048754 IDA     secondary heart field specification GO:0003139 IMP     hematopoietic progenitor cell differentiation GO:0002244 IDA     mesenchymal cell differentiation involved in kidney development GO:0072161 IEA     extracellular matrix organization GO:0030198 TAS     negative regulation of prostatic bud formation GO:0060686 IEA     epithelial cell proliferation involved in lung morphogenesis GO:0060502 IDA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA     endochondral ossification GO:0001958 ISS     BMP signaling pathway involved in renal system segmentation GO:0061151 ISS     ureteric bud development GO:0001657 IDA     negative regulation of cell death GO:0060548 IDA     trachea formation GO:0060440 IEA     positive regulation of neuron differentiation GO:0045666 IEA     embryonic skeletal joint morphogenesis GO:0060272 IEA     trachea development GO:0060438 IDA     neural tube closure GO:0001843 IEA     SMAD protein signal transduction GO:0060395 IDA     renal system process GO:0003014 IEA     positive regulation of bone mineralization GO:0030501 IDA     protein localization to nucleus GO:0034504 IDA     regulation of pathway-restricted SMAD protein phosphorylation GO:0060393 IDA     mesodermal cell fate determination GO:0007500 IEA     positive regulation of endothelial cell differentiation GO:0045603 IEA     branching involved in ureteric bud morphogenesis GO:0001658 IDA     positive regulation of collagen biosynthetic process GO:0032967 IDA     positive regulation of kidney development GO:0090184 IDA     positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IMP     positive regulation of epidermal cell differentiation GO:0045606 IDA     mammary gland formation GO:0060592 IEA     regulation of odontogenesis of dentin-containing tooth GO:0042487 IEA     positive regulation of cartilage development GO:0061036 IDA     intermediate mesodermal cell differentiation GO:0048392 IDA     positive regulation of protein binding GO:0032092 IDA     embryonic hindlimb morphogenesis GO:0035116 IEA     specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway GO:0072101 IDA     common-partner SMAD protein phosphorylation GO:0007182 IDA     cloacal septation GO:0060197 IEA     epithelial tube branching involved in lung morphogenesis GO:0060441 IDA     negative regulation of mesenchymal cell proliferation involved in ureter development GO:0072200 IDA     positive regulation of endothelial cell migration GO:0010595 IDA     lens induction in camera-type eye GO:0060235 IEA     embryonic cranial skeleton morphogenesis GO:0048701 IEA     negative regulation of metanephric S-shaped body morphogenesis GO:2000005 IDA     positive regulation of epithelial cell proliferation GO:0050679 IDA     positive regulation of cell death GO:0010942 IDA     blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 IDA     BMP signaling pathway involved in ureter morphogenesis GO:0061149 ISS     branching involved in prostate gland morphogenesis GO:0060442 IEA     erythrocyte differentiation GO:0030218 IEA     neuron fate commitment GO:0048663 IEA     pituitary gland development GO:0021983 IEA     BMP signaling pathway involved in nephric duct formation GO:0071893 IDA     mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 IDA     negative regulation of myoblast differentiation GO:0045662 IDA     positive regulation of osteoblast differentiation GO:0045669 IDA     mesonephros development GO:0001823 IEP     negative regulation of phosphorylation GO:0042326 IDA     metanephric collecting duct development GO:0072205 ISS     smooth muscle tissue development GO:0048745 ISS     bud dilation involved in lung branching GO:0060503 IDA     glomerular visceral epithelial cell development GO:0072015 IEA     negative regulation of immature T cell proliferation in thymus GO:0033088 IMP     positive chemotaxis GO:0050918 IDA     BMP signaling pathway GO:0030509 IMP     BMP signaling pathway involved in heart induction GO:0003130 IMP     dorsal/ventral neural tube patterning GO:0021904 IEA     negative regulation of metanephric comma-shaped body morphogenesis GO:2000007 IDA     positive regulation of endothelial cell proliferation GO:0001938 IDA     germ cell development GO:0007281 IEA     negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway GO:0072097 IDA     post-embryonic development GO:0009791 IDA     negative regulation of cell proliferation GO:0008285 IDA     positive regulation of BMP signaling pathway GO:0030513 ISS     macrophage differentiation GO:0030225 IDA     negative regulation of glomerulus development GO:0090194 IDA     negative regulation of chondrocyte differentiation GO:0032331 IEA     positive regulation of protein phosphorylation GO:0001934 IDA     ureter epithelial cell differentiation GO:0072192 ISS     negative regulation of mitotic nuclear division GO:0045839 IDA     negative regulation of transcription, DNA-templated GO:0045892 IDA     embryonic digit morphogenesis GO:0042733 IEA     positive regulation of transcription, DNA-templated GO:0045893 IDA     deltoid tuberosity development GO:0035993 ISS     positive regulation of apoptotic process GO:0043065 IDA     positive regulation of smooth muscle cell proliferation GO:0048661 IDA     inner ear receptor cell differentiation GO:0060113 IEA     positive regulation of cardiac muscle fiber development GO:0055020 IMP Subcellular Localization     extracellular space GO:0005615 ISS     extracellular region GO:0005576 TAS     proteinaceous extracellular matrix GO:0005578 IEA