Gene description for BMPR1A
Gene name bone morphogenetic protein receptor, type IA
Gene symbol BMPR1A
Other names/aliases 10q23del
ACVRLK3
ALK3
CD292
SKR5
Species Homo sapiens
 Database cross references - BMPR1A
ExoCarta ExoCarta_657
Vesiclepedia VP_657
Entrez Gene 657
HGNC 1076
MIM 601299
UniProt P36894  
 BMPR1A identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for BMPR1A
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IDA
    SMAD binding GO:0046332 IDA
    protein binding GO:0005515 IPI
    sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000981 IEA
    glycoprotein binding GO:0001948 IPI
    receptor signaling protein serine/threonine kinase activity GO:0004702 IEA
    transmembrane receptor protein serine/threonine kinase activity GO:0004675 TAS
    protein homodimerization activity GO:0042803 IDA
    metal ion binding GO:0046872 IEA
    ATP binding GO:0005524 IDA
Biological Process
    pituitary gland development GO:0021983 IEA
    transforming growth factor beta receptor signaling pathway GO:0007179 TAS
    hindlimb morphogenesis GO:0035137 IEA
    mesoderm formation GO:0001707 IEA
    positive regulation of mesenchymal cell proliferation GO:0002053 IEA
    embryonic digit morphogenesis GO:0042733 IEA
    signal transduction by protein phosphorylation GO:0023014 IEA
    cartilage development GO:0051216 IEA
    neural crest cell development GO:0014032 IEA
    positive regulation of SMAD protein import into nucleus GO:0060391 IDA
    dorsal/ventral axis specification GO:0009950 IEA
    positive regulation of epithelial cell proliferation GO:0050679 IEA
    odontogenesis of dentin-containing tooth GO:0042475 IEA
    lung development GO:0030324 IEA
    lateral mesoderm development GO:0048368 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IEA
    Mullerian duct regression GO:0001880 IEA
    developmental growth GO:0048589 IEA
    positive regulation of bone mineralization GO:0030501 IMP
    stem cell maintenance GO:0019827 IEA
    in utero embryonic development GO:0001701 IEA
    somitogenesis GO:0001756 IEA
    mesendoderm development GO:0048382 IEA
    BMP signaling pathway GO:0030509 TAS
    neural plate mediolateral regionalization GO:0021998 IEA
    regulation of cellular senescence GO:2000772 IEA
    negative regulation of neurogenesis GO:0050768 IEA
    palate development GO:0060021 IEA
    regulation of lateral mesodermal cell fate specification GO:0048378 IEA
    positive regulation of osteoblast differentiation GO:0045669 IMP
    paraxial mesoderm structural organization GO:0048352 IEA
    transcription from RNA polymerase II promoter GO:0006366 IEA
    ectoderm development GO:0007398 IEA
    immune response GO:0006955 IMP
    heart formation GO:0060914 IEA
    endocardial cushion formation GO:0003272 ISS
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IDA
    protein phosphorylation GO:0006468 IDA
    embryonic organ development GO:0048568 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    dendrite GO:0030425 IEA
    caveola GO:0005901 IMP
    external side of plasma membrane GO:0009897 IDA
    integral component of membrane GO:0016021 IEA
    HFE-transferrin receptor complex GO:1990712 IC
    neuronal cell body GO:0043025 IEA
 Experiment description of studies that identified BMPR1A in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for BMPR1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SF3B4 10262
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
2 FKBP1B  
Two-hybrid Homo sapiens
3 SMAD1 4086
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
4 GDF5 8200
Reconstituted Complex Homo sapiens
5 ZMYND11 10771
Invivo Homo sapiens
Two-hybrid Homo sapiens
6 Smad7  
Affinity Capture-Western Mus musculus
7 BMP2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
8 BMP5 653
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
9 TAB1 10454
Invivo Homo sapiens
Two-hybrid Homo sapiens
10 BMPR2 659
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
11 BMP4 652
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Invitro Homo sapiens
12 BMPR1A 657
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
13 SMAD7  
Affinity Capture-Western Homo sapiens
14 GDF9 2661
Invivo Homo sapiens
15 BMPR1B 658
Invivo Homo sapiens
16 BMP6  
Affinity Capture-Western Homo sapiens
17 TGFBRAP1 9392
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
18 GDF6 392255
Reconstituted Complex Homo sapiens
19 BMP7 655
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which BMPR1A is involved
PathwayEvidenceSource
Signaling by BMP TAS Reactome





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