Gene description for BMPR2
Gene name bone morphogenetic protein receptor, type II (serine/threonine kinase)
Gene symbol BMPR2
Other names/aliases BMPR-II
BMPR3
BMR2
BRK-3
POVD1
PPH1
T-ALK
Species Homo sapiens
 Database cross references - BMPR2
ExoCarta ExoCarta_659
Vesiclepedia VP_659
Entrez Gene 659
HGNC 1078
MIM 600799
UniProt Q13873  
 BMPR2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for BMPR2
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    activin receptor activity, type II GO:0016362 TAS
    metal ion binding GO:0046872 IEA
    receptor signaling protein serine/threonine kinase activity GO:0004702 IEA
    BMP binding GO:0036122 IPI
    growth factor binding GO:0019838 IEA
Biological Process
    regulation of lung blood pressure GO:0014916 ISS
    anterior/posterior pattern specification GO:0009952 ISS
    negative regulation of systemic arterial blood pressure GO:0003085 IMP
    positive regulation of endothelial cell proliferation GO:0001938 IMP
    positive regulation of BMP signaling pathway GO:0030513 IMP
    negative regulation of chondrocyte proliferation GO:1902731 IMP
    BMP signaling pathway GO:0030509 TAS
    chondrocyte development GO:0002063 IMP
    endothelial cell proliferation GO:0001935 IMP
    vascular endothelial growth factor receptor signaling pathway GO:0048010 ISS
    blood vessel remodeling GO:0001974 ISS
    retina vasculature development in camera-type eye GO:0061298 ISS
    positive regulation of axon extension involved in axon guidance GO:0048842 IEA
    limb development GO:0060173 IEA
    endothelial cell apoptotic process GO:0072577 IMP
    cellular response to starvation GO:0009267 IEP
    positive regulation of osteoblast differentiation GO:0045669 IMP
    negative regulation of vasoconstriction GO:0045906 ISS
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IMP
    lymphatic endothelial cell differentiation GO:0060836 ISS
    activin receptor signaling pathway GO:0032924 TAS
    positive regulation of cartilage development GO:0061036 ISS
    transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 IDA
    negative regulation of DNA biosynthetic process GO:2000279 IMP
    proteoglycan biosynthetic process GO:0030166 ISS
    artery development GO:0060840 ISS
    regulation of cell proliferation GO:0042127 IMP
    negative regulation of cell growth GO:0030308 IDA
    lung alveolus development GO:0048286 ISS
    brain development GO:0007420 IEA
    positive regulation of endothelial cell migration GO:0010595 IMP
    venous blood vessel development GO:0060841 ISS
    endochondral bone morphogenesis GO:0060350 ISS
    mesoderm formation GO:0001707 ISS
    lymphangiogenesis GO:0001946 ISS
    transcription from RNA polymerase II promoter GO:0006366 IMP
    positive regulation of epithelial cell migration GO:0010634 IDA
    signal transduction by protein phosphorylation GO:0023014 IEA
    positive regulation of bone mineralization GO:0030501 IMP
Subcellular Localization
    dendrite GO:0030425 IEA
    integral component of plasma membrane GO:0005887 IDA
    caveola GO:0005901 IMP
    spanning component of plasma membrane GO:0044214 TAS
    neuronal cell body GO:0043025 IEA
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IEA
    extracellular space GO:0005615 IDA
    cytoplasm GO:0005737 IEA
    apical plasma membrane GO:0016324 IEA
    basal plasma membrane GO:0009925 IEA
 Experiment description of studies that identified BMPR2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 211
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
EV Enriched markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 212
MISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
EV Enriched markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for BMPR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Serpina3k 20714
Affinity Capture-MS Mus musculus
2 Pdzrn3  
Affinity Capture-MS Mus musculus
3 LIMK1 3984
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 Lsp1  
Affinity Capture-MS Mus musculus
5 Mos  
Affinity Capture-MS Mus musculus
6 BMP2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 Tubb5 22154
Affinity Capture-MS Mus musculus
8 FRS3 10817
Affinity Capture-MS Homo sapiens
9 CES3 23491
Affinity Capture-MS Homo sapiens
10 CRYAB 1410
Affinity Capture-MS Homo sapiens
11 Actr8  
Affinity Capture-MS Mus musculus
12 GDF9 2661
Reconstituted Complex Homo sapiens
13 Lmx1a  
Affinity Capture-MS Mus musculus
14 Twf1 19230
Affinity Capture-MS Mus musculus
15 2810426N06Rik  
Affinity Capture-MS Mus musculus
16 GCGR  
Affinity Capture-MS Homo sapiens
17 Hnrnpr 74326
Affinity Capture-MS Mus musculus
18 BMPR1A 657
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 Prkcb1  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
20 Pmpca  
Affinity Capture-MS Mus musculus
21 BMPR1B 658
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
22 Rabggta  
Affinity Capture-MS Mus musculus
23 GDF6 392255
Reconstituted Complex Homo sapiens
24 ACVR1 90
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
25 TGFBR1 7046
Two-hybrid Homo sapiens
26 ACVR1B 91
Two-hybrid Homo sapiens
27 Sult1e1  
Affinity Capture-MS Mus musculus
28 BMPR2 659
Invivo Homo sapiens
Invivo Homo sapiens
29 Oc90  
Affinity Capture-MS Mus musculus
30 BMP7 655
Affinity Capture-Western Homo sapiens
31 Foxl1  
Affinity Capture-MS Mus musculus
32 BMP6  
Affinity Capture-Western Homo sapiens
33 Ctbp1 13016
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
34 TSR1 55720
Two-hybrid Homo sapiens
35 BMP4 652
Affinity Capture-Western Homo sapiens
36 Trpc1  
Affinity Capture-MS Mus musculus
37 GDF5 8200
Reconstituted Complex Homo sapiens
38 Asna1 56495
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which BMPR2 is involved
PathwayEvidenceSource
Signaling by BMP TAS Reactome





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