Gene description for BMPR2
Gene name bone morphogenetic protein receptor, type II (serine/threonine kinase)
Gene symbol BMPR2
Other names/aliases BMPR-II
BMPR3
BMR2
BRK-3
POVD1
PPH1
T-ALK
Species Homo sapiens
 Database cross references - BMPR2
ExoCarta ExoCarta_659
Vesiclepedia VP_659
Entrez Gene 659
HGNC 1078
MIM 600799
UniProt Q13873  
 BMPR2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for BMPR2
Molecular Function
    transforming growth factor beta receptor activity GO:0005024 IBA
    transforming growth factor beta receptor activity, type I GO:0005025 IEA
    transforming growth factor beta receptor activity, type II GO:0005026 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    activin receptor activity, type I GO:0016361 IEA
    activin receptor activity, type II GO:0016362 IDA
    activin receptor activity, type II GO:0016362 TAS
    growth factor binding GO:0019838 IEA
    BMP binding GO:0036122 IPI
    cadherin binding GO:0045296 IPI
    metal ion binding GO:0046872 IEA
    transforming growth factor beta receptor activity, type III GO:0070123 IEA
    BMP receptor activity GO:0098821 ISS
    protein tyrosine kinase binding GO:1990782 IPI
Biological Process
    blood vessel development GO:0001568 IBA
    osteoblast differentiation GO:0001649 IMP
    mesoderm formation GO:0001707 ISS
    maternal placenta development GO:0001893 IEA
    endothelial cell proliferation GO:0001935 IMP
    lymphangiogenesis GO:0001946 ISS
    blood vessel remodeling GO:0001974 ISS
    chondrocyte development GO:0002063 IMP
    negative regulation of systemic arterial blood pressure GO:0003085 IMP
    outflow tract septum morphogenesis GO:0003148 ISS
    outflow tract morphogenesis GO:0003151 ISS
    aortic valve development GO:0003176 ISS
    pulmonary valve development GO:0003177 ISS
    atrioventricular valve morphogenesis GO:0003181 ISS
    mitral valve morphogenesis GO:0003183 ISS
    tricuspid valve morphogenesis GO:0003186 ISS
    endocardial cushion development GO:0003197 ISS
    negative regulation of cell proliferation involved in heart valve morphogenesis GO:0003252 ISS
    cell surface receptor protein serine/threonine kinase signaling pathway GO:0007178 IDA
    cellular response to starvation GO:0009267 IEP
    anterior/posterior pattern specification GO:0009952 ISS
    positive regulation of gene expression GO:0010628 IMP
    positive regulation of epithelial cell migration GO:0010634 IDA
    regulation of lung blood pressure GO:0014916 IMP
    regulation of lung blood pressure GO:0014916 ISS
    cell differentiation GO:0030154 IDA
    proteoglycan biosynthetic process GO:0030166 ISS
    negative regulation of cell growth GO:0030308 IDA
    positive regulation of bone mineralization GO:0030501 IMP
    BMP signaling pathway GO:0030509 IBA
    BMP signaling pathway GO:0030509 IDA
    BMP signaling pathway GO:0030509 IGI
    BMP signaling pathway GO:0030509 IMP
    BMP signaling pathway GO:0030509 ISS
    BMP signaling pathway GO:0030509 TAS
    activin receptor signaling pathway GO:0032924 IEA
    regulation of cell population proliferation GO:0042127 IMP
    positive regulation of osteoblast differentiation GO:0045669 IMP
    positive regulation of ossification GO:0045778 ISS
    negative regulation of vasoconstriction GO:0045906 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    lung alveolus development GO:0048286 ISS
    negative regulation of smooth muscle cell proliferation GO:0048662 IMP
    cardiac muscle tissue development GO:0048738 ISS
    positive regulation of axon extension involved in axon guidance GO:0048842 IEA
    stem cell differentiation GO:0048863 ISS
    negative regulation of muscle cell differentiation GO:0051148 IEA
    limb development GO:0060173 IEA
    endochondral bone morphogenesis GO:0060350 ISS
    positive regulation of SMAD protein signal transduction GO:0060391 IGI
    positive regulation of SMAD protein signal transduction GO:0060391 IMP
    ventricular septum morphogenesis GO:0060412 ISS
    atrial septum morphogenesis GO:0060413 ISS
    lung vasculature development GO:0060426 IMP
    lymphatic endothelial cell differentiation GO:0060836 ISS
    artery development GO:0060840 ISS
    venous blood vessel development GO:0060841 ISS
    positive regulation of cartilage development GO:0061036 ISS
    retina vasculature development in camera-type eye GO:0061298 ISS
    pharyngeal arch artery morphogenesis GO:0061626 ISS
    cellular response to growth factor stimulus GO:0071363 IBA
    cellular response to BMP stimulus GO:0071773 IMP
    endothelial cell apoptotic process GO:0072577 IMP
    negative regulation of chondrocyte proliferation GO:1902731 IMP
    semi-lunar valve development GO:1905314 ISS
Subcellular Localization
    extracellular space GO:0005615 HDA
    nucleoplasm GO:0005654 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    caveola GO:0005901 IMP
    clathrin-coated pit GO:0005905 IEA
    adherens junction GO:0005912 IDA
    basal plasma membrane GO:0009925 IEA
    cell surface GO:0009986 IEA
    postsynaptic density GO:0014069 IEA
    apical plasma membrane GO:0016324 IEA
    axon GO:0030424 IEA
    dendrite GO:0030425 IEA
    neuronal cell body GO:0043025 IEA
    receptor complex GO:0043235 IBA
 Experiment description of studies that identified BMPR2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for BMPR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 Serpina3k 20714
Affinity Capture-MS Mus musculus
3 Pdzrn3  
Affinity Capture-MS Mus musculus
4 TRIB3  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
5 LIMK1 3984
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
6 MIB1 57534
Affinity Capture-MS Homo sapiens
7 Mos  
Affinity Capture-MS Mus musculus
8 BMP2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
9 Prkcb  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
10 BMP10  
Reconstituted Complex Homo sapiens
11 GDF2 2658
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
12 MCAM 4162
Proximity Label-MS Homo sapiens
13 SMAD7  
Affinity Capture-Western Homo sapiens
14 Tubb5 22154
Affinity Capture-MS Mus musculus
15 RNF11 26994
Affinity Capture-MS Homo sapiens
16 CES3 23491
Affinity Capture-MS Homo sapiens
17 MARCH1  
Affinity Capture-MS Homo sapiens
18 CD83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 PYCARD 29108
Affinity Capture-MS Homo sapiens
20 CRYAB 1410
Affinity Capture-MS Homo sapiens
21 FST 10468
Co-crystal Structure Homo sapiens
22 Actr8  
Affinity Capture-MS Mus musculus
23 GDF9 2661
Reconstituted Complex Homo sapiens
24 Foxl1  
Affinity Capture-MS Mus musculus
25 LRRIQ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 Twf1 19230
Affinity Capture-MS Mus musculus
27 TSR1 55720
Two-hybrid Homo sapiens
28 NRSN1  
Affinity Capture-MS Homo sapiens
29 GCGR  
Affinity Capture-MS Homo sapiens
30 RPS15 6209
Cross-Linking-MS (XL-MS) Homo sapiens
31 FRS3 10817
Affinity Capture-MS Homo sapiens
32 Hnrnpr 74326
Affinity Capture-MS Mus musculus
33 BMPR1A 657
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
34 Pmpca  
Affinity Capture-MS Mus musculus
35 Rabggta  
Affinity Capture-MS Mus musculus
36 BMP4 652
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
37 GDF6 392255
Reconstituted Complex Homo sapiens
38 ACVR1 90
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
39 TGFBR1 7046
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
40 PPP1CC 5501
Two-hybrid Homo sapiens
41 Lsp1  
Affinity Capture-MS Mus musculus
42 KCNE3  
Affinity Capture-MS Homo sapiens
43 TDGF1  
Reconstituted Complex Homo sapiens
44 ACVR1B 91
Two-hybrid Homo sapiens
45 CDH1 999
Proximity Label-MS Homo sapiens
46 BMPR1B 658
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
47 Zfp788  
Affinity Capture-MS Mus musculus
48 C16orf58 64755
Affinity Capture-MS Homo sapiens
49 Oc90  
Affinity Capture-MS Mus musculus
50 XIAP  
Affinity Capture-Western Homo sapiens
51 Lmx1a  
Affinity Capture-MS Mus musculus
52 BMP7 655
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
53 DES 1674
Affinity Capture-MS Homo sapiens
54 Sult1e1  
Affinity Capture-MS Mus musculus
55 INHBB 3625
Reconstituted Complex Homo sapiens
56 BMPR2 659
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
57 SMAD6  
Affinity Capture-Western Homo sapiens
58 MYH11 4629
Affinity Capture-MS Homo sapiens
59 BMP6  
Affinity Capture-Western Homo sapiens
60 Ctbp1 13016
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
61 MAPK8 5599
Two-hybrid Homo sapiens
62 MRAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 Trpc1  
Affinity Capture-MS Mus musculus
64 FHL2 2274
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
65 C14orf37  
Affinity Capture-MS Homo sapiens
66 GDF5 8200
Reconstituted Complex Homo sapiens
67 Asna1 56495
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which BMPR2 is involved
PathwayEvidenceSource
Signal Transduction TAS Reactome
Signaling by BMP TAS Reactome
Signaling by TGFB family members TAS Reactome





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