Ctbp1
Gene name
C-terminal binding protein 1
Gene symbol
Ctbp1
Other names/aliases
BARS
Species
Mus musculus
Ctbp1
ExoCarta
ExoCarta_13016
Vesiclepedia
VP_13016
Entrez Gene
13016
UniProt
O88712
Ctbp1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells
37309723
T-cell lymphoma cells
37309723
Ctbp1
Molecular Function
dihydrotestosterone 17-beta-dehydrogenase activity GO:0035410 IEA
aldo-keto reductase (NADP) activity GO:0004033 IEA
acetoin dehydrogenase activity GO:0019152 IEA
repressing transcription factor binding GO:0070491 ISO
NAD binding GO:0051287 ISO
D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity GO:0052677 IEA
(R)-2-hydroxyisocaproate dehydrogenase activity GO:0043713 IEA
gluconate dehydrogenase activity GO:0008875 IEA
sequence-specific DNA binding transcription factor activity GO:0003700 IDA
protein binding GO:0005515 IPI
oxidoreductase activity GO:0016491 IEA
(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity GO:0034831 IEA
L-arabinose 1-dehydrogenase (NADP+) activity GO:0044103 IEA
D-xylose:NADP reductase activity GO:0032866 IEA
protein homodimerization activity GO:0042803 ISO
5-exo-hydroxycamphor dehydrogenase activity GO:0018452 IEA
(R)-2-hydroxyglutarate dehydrogenase activity GO:0051990 IEA
2-hydroxytetrahydrofuran dehydrogenase activity GO:0018453 IEA
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity GO:0000252 IEA
L-arabinose:NADP reductase activity GO:0032867 IEA
protein domain specific binding GO:0019904 ISO
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0033764 IEA
RNA polymerase II transcription corepressor activity GO:0001106 ISO
3-hydroxymenthone dehydrogenase activity GO:0034840 IEA
L-xylulose reductase (NAD+) activity GO:0044105 IEA
mevaldate reductase activity GO:0004495 IEA
epoxide dehydrogenase activity GO:0018451 IEA
3-ketoglucose-reductase activity GO:0048258 IEA
phenylcoumaran benzylic ether reductase activity GO:0032442 IEA
steroid dehydrogenase activity GO:0016229 IEA
isocitrate dehydrogenase activity GO:0004448 IEA
transcription factor binding GO:0008134 ISO
steroid dehydrogenase activity, acting on the CH-CH group of donors GO:0033765 IEA
D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity GO:0033709 IEA
very long-chain-3-hydroxyacyl-CoA dehydrogenase activity GO:0035380 IEA
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 IEA
Biological Process
negative regulation of transcription, DNA-templated GO:0045892 IDA
regulation of cell cycle GO:0051726 ISO
metabolic process GO:0008152 IEA
positive regulation of histone deacetylation GO:0031065 ISO
transcription, DNA-templated GO:0006351 IEA
negative regulation of histone acetylation GO:0035067 ISO
transcription from RNA polymerase II promoter GO:0006366 ISO
negative regulation of histone H4 acetylation GO:0090241 ISO
regulation of transcription, DNA-templated GO:0006355 IEA
negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
oxidation-reduction process GO:0055114 IEA
cell differentiation GO:0030154 IEA
negative regulation of transcription from RNA polymerase II promoter by histone modification GO:1903758 ISO
white fat cell differentiation GO:0050872 IDA
Subcellular Localization
transcription factor complex GO:0005667 IDA
nucleus GO:0005634 ISO
cytoplasm GO:0005737 IEA
transcriptional repressor complex GO:0017053 ISO
nucleoplasm GO:0005654 ISO
Ctbp1 in exosomes
1
Experiment ID
907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
37309723
Organism
Mus musculus
Experiment description
Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors
Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name
Proteomics
Publication year
2023
Sample
Colon cancer cells
Sample name
C26
Isolation/purification methods
Differential centrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting
2
Experiment ID
908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
37309723
Organism
Mus musculus
Experiment description
Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors
Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name
Proteomics
Publication year
2023
Sample
T-cell lymphoma cells
Sample name
EL4
Isolation/purification methods
Differential centrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting
Ctbp1
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
BMPR2
659
Affinity Capture-Western
Homo sapiens
Affinity Capture-MS
Homo sapiens
2
HDAC4
Two-hybrid
Homo sapiens
3
HIC1
Two-hybrid
Homo sapiens
Affinity Capture-Western
Homo sapiens
Co-localization
Homo sapiens
Reconstituted Complex
Homo sapiens
4
Zfhx1a
Two-hybrid
Mus musculus
5
ZNFN1A4
Reconstituted Complex
Homo sapiens
View the network
image/svg+xml
Ctbp1 is involved
Gene description for Ctbp1
