Gene description for GDF6
Gene name growth differentiation factor 6
Gene symbol GDF6
Other names/aliases BMP-13
BMP13
CDMP2
KFM
KFS
KFS1
KFSL
LCA17
MCOP4
MCOPCB6
SCDO4
SGM1
Species Homo sapiens
 Database cross references - GDF6
ExoCarta ExoCarta_392255
Vesiclepedia VP_392255
Entrez Gene 392255
HGNC 4221
MIM 601147
UniProt Q6KF10  
 GDF6 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for GDF6
Molecular Function
    cytokine activity GO:0005125 IBA
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IEA
    identical protein binding GO:0042802 IEA
Biological Process
    metanephros development GO:0001656 IDA
    apoptotic process GO:0006915 ISS
    epithelial cell migration GO:0010631 IEA
    BMP signaling pathway GO:0030509 IBA
    BMP signaling pathway GO:0030509 IDA
    positive regulation of chondrocyte differentiation GO:0032332 IMP
    activin receptor signaling pathway GO:0032924 IDA
    cell migration involved in metanephros development GO:0035788 IEA
    fat cell differentiation GO:0045444 ISS
    positive regulation of neuron differentiation GO:0045666 IEA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of SMAD protein signal transduction GO:0060391 IDA
    positive regulation of SMAD protein signal transduction GO:0060391 IMP
    positive regulation of SMAD protein signal transduction GO:0060391 ISS
    positive regulation of p38MAPK cascade GO:1900745 ISS
    retinal cell apoptotic process GO:1990009 ISS
Subcellular Localization
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified GDF6 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GDF6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BMPR1B 658
Reconstituted Complex Homo sapiens
2 BMPR2 659
Reconstituted Complex Homo sapiens
3 BMPR1A 657
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which GDF6 is involved
No pathways found





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