Gene description for GDF6
Gene name growth differentiation factor 6
Gene symbol GDF6
Other names/aliases BMP-13
BMP13
CDMP2
KFM
KFS
KFS1
KFSL
LCA17
MCOP4
MCOPCB6
SCDO4
SGM1
Species Homo sapiens
 Database cross references - GDF6
ExoCarta ExoCarta_392255
Vesiclepedia VP_392255
Entrez Gene 392255
HGNC 4221
MIM 601147
UniProt Q6KF10  
 GDF6 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for GDF6
Molecular Function
    cytokine activity GO:0005125 IBA
    growth factor activity GO:0008083 IEA
    transforming growth factor beta receptor binding GO:0005160 IBA
    protein homodimerization activity GO:0042803 IEA
Biological Process
    pathway-restricted SMAD protein phosphorylation GO:0060389 IDA
    growth GO:0040007 IEA
    BMP signaling pathway GO:0030509 IDA
    apoptotic process GO:0006915 ISS
    activin receptor signaling pathway GO:0032924 IDA
    retinal cell apoptotic process GO:1990009 ISS
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IDA
    regulation of apoptotic process GO:0042981 IBA
    cell development GO:0048468 IBA
    positive regulation of neuron differentiation GO:0045666 IEA
    SMAD protein signal transduction GO:0060395 IBA
    regulation of MAPK cascade GO:0043408 IBA
    positive regulation of transcription, DNA-templated GO:0045893 IDA
Subcellular Localization
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified GDF6 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GDF6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BMPR1B 658
Reconstituted Complex Homo sapiens
2 BMPR2 659
Reconstituted Complex Homo sapiens
3 BMPR1A 657
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which GDF6 is involved
No pathways found





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