Gene description for BMPR1B
Gene name bone morphogenetic protein receptor, type IB
Gene symbol BMPR1B
Other names/aliases ALK-6
ALK6
CDw293
Species Homo sapiens
 Database cross references - BMPR1B
ExoCarta ExoCarta_658
Vesiclepedia VP_658
Entrez Gene 658
HGNC 1077
MIM 603248
UniProt O00238  
 BMPR1B identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for BMPR1B
Molecular Function
    transforming growth factor beta receptor activity, type I GO:0005025 IEA
    protein binding GO:0005515 IPI
    transmembrane receptor protein serine/threonine kinase activity GO:0004675 NAS
    ATP binding GO:0005524 IDA
    protein serine/threonine kinase activity GO:0004674 IDA
    receptor signaling protein serine/threonine kinase activity GO:0004702 IEA
    glycoprotein binding GO:0001948 IPI
    SMAD binding GO:0046332 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    dorsal/ventral pattern formation GO:0009953 IEA
    BMP signaling pathway GO:0030509 TAS
    positive regulation of bone mineralization GO:0030501 IMP
    cartilage condensation GO:0001502 NAS
    retinal ganglion cell axon guidance GO:0031290 IEA
    eye development GO:0001654 ISS
    chondrocyte development GO:0002063 ISS
    ovarian cumulus expansion GO:0001550 ISS
    skeletal system development GO:0001501 IMP
    proteoglycan biosynthetic process GO:0030166 ISS
    positive regulation of cell differentiation GO:0045597 IMP
    limb morphogenesis GO:0035108 IMP
    positive regulation of osteoblast differentiation GO:0045669 IMP
    protein phosphorylation GO:0006468 IDA
    negative regulation of chondrocyte proliferation GO:1902731 ISS
    retina development in camera-type eye GO:0060041 IEA
    inflammatory response GO:0006954 IEA
    endochondral bone morphogenesis GO:0060350 ISS
    positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 IEA
    positive regulation of cartilage development GO:0061036 ISS
    signal transduction by protein phosphorylation GO:0023014 IEA
    ovulation cycle GO:0042698 ISS
Subcellular Localization
    receptor complex GO:0043235 TAS
    integral component of plasma membrane GO:0005887 IC
    plasma membrane GO:0005886 TAS
    HFE-transferrin receptor complex GO:1990712 IC
 Experiment description of studies that identified BMPR1B in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BMPR1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rps27a 78294
Affinity Capture-Luminescence Mus musculus
2 Rasd2  
Affinity Capture-Luminescence Mus musculus
3 Rab6b  
Affinity Capture-Luminescence Mus musculus
4 Sh3kbp1 58194
Affinity Capture-Luminescence Mus musculus
5 Srgap1  
Affinity Capture-Luminescence Mus musculus
6 BMP2  
Invivo Homo sapiens
7 1700012F10Rik  
Affinity Capture-Luminescence Mus musculus
8 Ppp3cc  
Affinity Capture-Luminescence Mus musculus
9 Stk35  
Affinity Capture-Luminescence Mus musculus
10 Usp45  
Affinity Capture-Luminescence Mus musculus
11 Rhebl1  
Affinity Capture-Luminescence Mus musculus
12 Fkbp1b  
Affinity Capture-Luminescence Mus musculus
13 Uhmk1  
Affinity Capture-Luminescence Mus musculus
14 Bcr  
Affinity Capture-Luminescence Mus musculus
15 Stub1 56424
Affinity Capture-Luminescence Mus musculus
16 Nkiras1  
Affinity Capture-Luminescence Mus musculus
17 Smad7  
Affinity Capture-Luminescence Mus musculus
18 Cdk4  
Affinity Capture-Luminescence Mus musculus
19 Arhgef6  
Affinity Capture-Luminescence Mus musculus
20 BMPR1A 657
Invivo Homo sapiens
21 Irf7  
Affinity Capture-Luminescence Mus musculus
22 Fbxo34  
Affinity Capture-Luminescence Mus musculus
23 Mknk2  
Affinity Capture-Luminescence Mus musculus
24 BMPR1B 658
Invivo Homo sapiens
Invivo Homo sapiens
25 Rhoj  
Affinity Capture-Luminescence Mus musculus
26 GDF6 392255
Reconstituted Complex Homo sapiens
27 SNX6 58533
Invivo Homo sapiens
Invitro Homo sapiens
28 Rras2 66922
Affinity Capture-Luminescence Mus musculus
29 Rab38  
Affinity Capture-Luminescence Mus musculus
30 Klhl1  
Affinity Capture-Luminescence Mus musculus
31 Ppp2ca 19052
Affinity Capture-Luminescence Mus musculus
32 Tgfbr1 21812
Affinity Capture-Luminescence Mus musculus
33 Fbxo3  
Affinity Capture-Luminescence Mus musculus
34 Ilkap  
Affinity Capture-Luminescence Mus musculus
35 Fancl  
Affinity Capture-Luminescence Mus musculus
36 Rhobtb1  
Affinity Capture-Luminescence Mus musculus
37 Bmpr2 12168
Affinity Capture-Luminescence Mus musculus
38 NAA20  
Affinity Capture-Luminescence Mus musculus
39 Smad6  
Affinity Capture-Luminescence Mus musculus
40 Map2k3  
Affinity Capture-Luminescence Mus musculus
41 Lztr1  
Affinity Capture-Luminescence Mus musculus
42 Apg16l  
Affinity Capture-Luminescence Mus musculus
43 Rhod  
Affinity Capture-Luminescence Mus musculus
44 BMP7 655
Reconstituted Complex Homo sapiens
45 5830461H18Rik  
Affinity Capture-Luminescence Mus musculus
46 Sqstm1  
Affinity Capture-Luminescence Mus musculus
47 BMPR2 659
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
48 Chn1  
Affinity Capture-Luminescence Mus musculus
49 Fkbp1a 14225
Affinity Capture-Luminescence Mus musculus
50 Fbxw5  
Affinity Capture-Luminescence Mus musculus
51 1700006A11Rik 71824
Affinity Capture-Luminescence Mus musculus
52 BMP4 652
Reconstituted Complex Homo sapiens
Invitro Homo sapiens
53 Plekhb1  
Affinity Capture-Luminescence Mus musculus
54 GDF5 8200
Reconstituted Complex Homo sapiens
55 Pftk1  
Affinity Capture-Luminescence Mus musculus
View the network image/svg+xml
 Pathways in which BMPR1B is involved
PathwayEvidenceSource
Signaling by BMP TAS Reactome





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