Gene description for Fkbp1a
Gene name FK506 binding protein 1a
Gene symbol Fkbp1a
Other names/aliases FKBP12
Fkbp
Fkbp1
Species Mus musculus
 Database cross references - Fkbp1a
ExoCarta ExoCarta_14225
Vesiclepedia VP_14225
Entrez Gene 14225
UniProt P26883  
 Fkbp1a identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Fkbp1a
Molecular Function
    SMAD binding GO:0046332 ISO
    drug binding GO:0008144 IDA
    FK506 binding GO:0005528 ISO
    protein homodimerization activity GO:0042803 IDA
    transforming growth factor beta receptor binding GO:0005160 ISO
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 ISO
    activin binding GO:0048185 ISO
    ion channel binding GO:0044325 IPI
    type I transforming growth factor beta receptor binding GO:0034713 ISO
    Hsp70 protein binding GO:0030544 ISO
    isomerase activity GO:0016853 IEA
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 ISO
    signal transducer activity GO:0004871 ISO
    calcium channel inhibitor activity GO:0019855 IBA
Biological Process
    heart morphogenesis GO:0003007 IMP
    regulation of protein localization GO:0032880 ISO
    regulation of activin receptor signaling pathway GO:0032925 ISO
    heart trabecula formation GO:0060347 IMP
    response to caffeine GO:0031000 IMP
    muscle contraction GO:0006936 IMP
    regulation of amyloid precursor protein catabolic process GO:1902991 ISO
    protein peptidyl-prolyl isomerization GO:0000413 ISO
    cytokine-mediated signaling pathway GO:0019221 IMP
    T cell proliferation GO:0042098 IMP
    negative regulation of release of sequestered calcium ion into cytosol GO:0051280 IBA
    positive regulation of protein ubiquitination GO:0031398 ISO
    release of sequestered calcium ion into cytosol GO:0051209 IMP
    negative regulation of protein phosphorylation GO:0001933 IDA
    SMAD protein complex assembly GO:0007183 ISO
    amyloid fibril formation GO:1990000 ISO
    positive regulation of protein binding GO:0032092 ISO
    regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 ISO
    protein folding GO:0006457 IEA
    negative regulation of protein phosphatase type 2B activity GO:0032513 ISO
    chaperone-mediated protein folding GO:0061077 IBA
    regulation of immune response GO:0050776 ISO
    ventricular cardiac muscle tissue morphogenesis GO:0055010 IMP
    extracellular fibril organization GO:0043206 ISO
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 ISO
Subcellular Localization
    extracellular matrix GO:0031012 ISO
    cytosol GO:0005829 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    Z disc GO:0030018 ISO
    cytoplasm GO:0005737 ISO
    membrane GO:0016020 ISO
    extracellular exosome GO:0070062 ISO
    intracellular GO:0005622 IMP
    axon terminus GO:0043679 ISO
    sarcoplasmic reticulum membrane GO:0033017 IDA
    cell GO:0005623 IMP
 Experiment description of studies that identified Fkbp1a in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Fkbp1a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BMPR1B 658
Affinity Capture-Luminescence Homo sapiens
2 TGFBR1 7046
Affinity Capture-Luminescence Homo sapiens
View the network image/svg+xml



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