Gene description for TGFBR1
Gene name transforming growth factor, beta receptor 1
Gene symbol TGFBR1
Other names/aliases AAT5
ACVRLK4
ALK-5
ALK5
ESS1
LDS1
LDS1A
LDS2A
MSSE
SKR4
TGFR-1
tbetaR-I
Species Homo sapiens
 Database cross references - TGFBR1
ExoCarta ExoCarta_7046
Vesiclepedia VP_7046
Entrez Gene 7046
HGNC 11772
MIM 190181
UniProt P36897  
 TGFBR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for TGFBR1
Molecular Function
    ATP binding GO:0005524 IDA
    receptor signaling protein activity GO:0005057 ISS
    transforming growth factor beta receptor activity, type I GO:0005025 ISS
    transforming growth factor beta-activated receptor activity GO:0005024 IMP
    transforming growth factor beta binding GO:0050431 ISS
    metal ion binding GO:0046872 IEA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein binding GO:0005515 IPI
    I-SMAD binding GO:0070411 IPI
    protein kinase activity GO:0004672 IDA
    receptor signaling protein serine/threonine kinase activity GO:0004702 IEA
    growth factor binding GO:0019838 IPI
    type II transforming growth factor beta receptor binding GO:0005114 IPI
    SMAD binding GO:0046332 IPI
Biological Process
    activin receptor signaling pathway GO:0032924 ISS
    neuron fate commitment GO:0048663 ISS
    in utero embryonic development GO:0001701 ISS
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IDA
    regulation of epithelial to mesenchymal transition GO:0010717 ISS
    thymus development GO:0048538 ISS
    artery morphogenesis GO:0048844 ISS
    positive regulation of endothelial cell proliferation GO:0001938 ISS
    collagen fibril organization GO:0030199 ISS
    cell motility GO:0048870 IMP
    wound healing GO:0042060 TAS
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 TAS
    positive regulation of cell growth GO:0030307 IDA
    embryonic cranial skeleton morphogenesis GO:0048701 ISS
    positive regulation of transcription, DNA-templated GO:0045893 ISS
    angiogenesis GO:0001525 IEA
    germ cell migration GO:0008354 ISS
    transforming growth factor beta receptor signaling pathway GO:0007179 TAS
    protein phosphorylation GO:0006468 IDA
    anterior/posterior pattern specification GO:0009952 ISS
    regulation of protein binding GO:0043393 IEA
    cellular response to transforming growth factor beta stimulus GO:0071560 IDA
    signal transduction by protein phosphorylation GO:0023014 IEA
    skeletal system development GO:0001501 ISS
    response to cholesterol GO:0070723 IDA
    endothelial cell activation GO:0042118 ISS
    cardiac epithelial to mesenchymal transition GO:0060317 ISS
    extracellular structure organization GO:0043062 TAS
    regulation of protein ubiquitination GO:0031396 IDA
    positive regulation of apoptotic signaling pathway GO:2001235 IDA
    positive regulation of cell proliferation GO:0008284 IMP
    positive regulation of filopodium assembly GO:0051491 IEA
    peptidyl-threonine phosphorylation GO:0018107 IDA
    pathway-restricted SMAD protein phosphorylation GO:0060389 IDA
    kidney development GO:0001822 ISS
    skeletal system morphogenesis GO:0048705 ISS
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IMP
    post-embryonic development GO:0009791 IEA
    positive regulation of gene expression GO:0010628 ISS
    positive regulation of cellular component movement GO:0051272 IMP
    pharyngeal system development GO:0060037 ISS
    palate development GO:0060021 ISS
    heart development GO:0007507 ISS
    activation of MAPKK activity GO:0000186 IDA
    intracellular signal transduction GO:0035556 ISS
    cell cycle arrest GO:0007050 TAS
    negative regulation of endothelial cell proliferation GO:0001937 IEA
    regulation of transcription, DNA-templated GO:0006355 IMP
    signal transduction GO:0007165 IDA
    regulation of gene expression GO:0010468 ISS
    mesenchymal cell differentiation GO:0048762 TAS
    positive regulation of protein kinase B signaling GO:0051897 IDA
    endothelial cell migration GO:0043542 IEA
    male gonad development GO:0008584 IEA
    apoptotic process GO:0006915 IEA
    blastocyst development GO:0001824 IEA
    epithelial to mesenchymal transition GO:0001837 IDA
    peptidyl-serine phosphorylation GO:0018105 IDA
    lens development in camera-type eye GO:0002088 IEA
    negative regulation of chondrocyte differentiation GO:0032331 ISS
    parathyroid gland development GO:0060017 ISS
    positive regulation of SMAD protein import into nucleus GO:0060391 IDA
Subcellular Localization
    membrane GO:0016020 ISS
    receptor complex GO:0043235 IDA
    intracellular GO:0005622 ISS
    bicellular tight junction GO:0005923 IDA
    transforming growth factor beta receptor homodimeric complex GO:0070022 IC
    cell GO:0005623 ISS
    plasma membrane GO:0005886 TAS
    endosome GO:0005768 IEA
 Experiment description of studies that identified TGFBR1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TGFBR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Csnk1d  
Affinity Capture-Luminescence Mus musculus
2 Wdr13  
Affinity Capture-Luminescence Mus musculus
3 AP2B1 163
Affinity Capture-Western Homo sapiens
4 Ppp3cc  
Affinity Capture-Luminescence Mus musculus
5 Ubb 22187
Affinity Capture-Luminescence Mus musculus
6 Stk35  
Affinity Capture-Luminescence Mus musculus
7 Anapc5 59008
Affinity Capture-Luminescence Mus musculus
8 Rhebl1  
Affinity Capture-Luminescence Mus musculus
9 Stub1 56424
Affinity Capture-Luminescence Mus musculus
10 Ubd 24108
Affinity Capture-Luminescence Mus musculus
11 Cdk4  
Affinity Capture-Luminescence Mus musculus
12 Tssk5  
Affinity Capture-Luminescence Mus musculus
13 Eif2ak1  
Affinity Capture-Luminescence Mus musculus
14 TGFB3 7043
Invivo Homo sapiens
15 Rrh  
Affinity Capture-Luminescence Mus musculus
16 SNX6 58533
Invivo Homo sapiens
Invitro Homo sapiens
17 Ppp1ca 19045
Affinity Capture-Luminescence Mus musculus
18 Sntg1  
Affinity Capture-Luminescence Mus musculus
19 Aurkb  
Affinity Capture-Luminescence Mus musculus
20 5830461H18Rik  
Affinity Capture-Luminescence Mus musculus
21 TGFB1 7040
Affinity Capture-Western Homo sapiens
22 CLU 1191
Invivo Homo sapiens
Invitro Homo sapiens
23 Apg16l  
Affinity Capture-Luminescence Mus musculus
24 Rhoj  
Affinity Capture-Luminescence Mus musculus
25 Rab34  
Affinity Capture-Luminescence Mus musculus
26 Rhoh 74734
Affinity Capture-Luminescence Mus musculus
27 Chuk  
Affinity Capture-Luminescence Mus musculus
28 Csnk2a2 13000
Affinity Capture-Luminescence Mus musculus
29 Prpf4  
Affinity Capture-Luminescence Mus musculus
30 Ppp6c 67857
Affinity Capture-Luminescence Mus musculus
31 Git2  
Affinity Capture-Luminescence Mus musculus
32 Cdkl1  
Affinity Capture-Luminescence Mus musculus
33 Chn2  
Affinity Capture-Luminescence Mus musculus
34 Rab6b  
Affinity Capture-Luminescence Mus musculus
35 Usp45  
Affinity Capture-Luminescence Mus musculus
36 Itk  
Affinity Capture-Luminescence Mus musculus
37 Wwp2  
Affinity Capture-Luminescence Mus musculus
38 Katnb1  
Affinity Capture-Luminescence Mus musculus
39 Fkbp1b  
Affinity Capture-Luminescence Mus musculus
40 Rtkn  
Affinity Capture-Luminescence Mus musculus
41 Arhgef6  
Affinity Capture-Luminescence Mus musculus
42 Fbxo24  
Affinity Capture-Luminescence Mus musculus
43 Usp21  
Affinity Capture-Luminescence Mus musculus
44 Nkiras1  
Affinity Capture-Luminescence Mus musculus
45 ARHGAP31  
Affinity Capture-Luminescence Mus musculus
46 Efna1  
Affinity Capture-Luminescence Mus musculus
47 Wsb1  
Affinity Capture-Luminescence Mus musculus
48 Fancl  
Affinity Capture-Luminescence Mus musculus
49 Tssk3  
Affinity Capture-Luminescence Mus musculus
50 Wdr61  
Affinity Capture-Luminescence Mus musculus
51 Map2k3  
Affinity Capture-Luminescence Mus musculus
52 Rhoa 11848
Affinity Capture-Luminescence Mus musculus
53 Nup37  
Affinity Capture-Luminescence Mus musculus
54 Fbxw5  
Affinity Capture-Luminescence Mus musculus
55 Ocln  
Affinity Capture-Luminescence Mus musculus
56 Bcr  
Affinity Capture-Luminescence Mus musculus
57 Dapk2  
Affinity Capture-Luminescence Mus musculus
58 PIK3R1 5295
Invivo Homo sapiens
59 Preb  
Affinity Capture-Luminescence Mus musculus
60 Ikbkb 16150
Affinity Capture-Luminescence Mus musculus
61 Pard6a  
Affinity Capture-Luminescence Mus musculus
62 Pftk1  
Affinity Capture-Luminescence Mus musculus
63 Btbd2  
Affinity Capture-Luminescence Mus musculus
64 1200013B22Rik  
Affinity Capture-Luminescence Mus musculus
65 Gnb3  
Affinity Capture-Luminescence Mus musculus
66 Smad7  
Affinity Capture-Western Mus musculus
Affinity Capture-Luminescence Mus musculus
67 ZAK 51776
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
68 Rhpn2  
Affinity Capture-Luminescence Mus musculus
69 Gnb2 14693
Affinity Capture-Luminescence Mus musculus
70 Ube2e3  
Affinity Capture-Luminescence Mus musculus
71 Enc1  
Affinity Capture-Luminescence Mus musculus
72 Fbxl12  
Affinity Capture-Luminescence Mus musculus
73 Bmpr2 12168
Affinity Capture-Luminescence Mus musculus
74 Samd8  
Affinity Capture-Luminescence Mus musculus
75 Rab3b  
Affinity Capture-Luminescence Mus musculus
76 Plek  
Affinity Capture-Luminescence Mus musculus
77 Noxo1  
Affinity Capture-Luminescence Mus musculus
78 Rgs19  
Affinity Capture-Luminescence Mus musculus
79 FNTA 2339
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
80 Ttc1  
Affinity Capture-Luminescence Mus musculus
81 Csnk1a1 93687
Affinity Capture-Luminescence Mus musculus
82 Rnf138  
Affinity Capture-Luminescence Mus musculus
83 Stat1 20846
Affinity Capture-Luminescence Mus musculus
84 STRAP 11171
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
85 Rab38  
Affinity Capture-Luminescence Mus musculus
86 Tgfbr1 21812
Affinity Capture-Luminescence Mus musculus
87 Stx8 55943
Affinity Capture-Luminescence Mus musculus
88 Ilkap  
Affinity Capture-Luminescence Mus musculus
89 BMPR2 659
Two-hybrid Homo sapiens
90 Rhobtb1  
Affinity Capture-Luminescence Mus musculus
91 Cdc42ep4  
Affinity Capture-Luminescence Mus musculus
92 Rhod  
Affinity Capture-Luminescence Mus musculus
93 Eif2ak4  
Affinity Capture-Luminescence Mus musculus
94 Chn1  
Affinity Capture-Luminescence Mus musculus
95 Pctk2  
Affinity Capture-Luminescence Mus musculus
96 Rab33b  
Affinity Capture-Luminescence Mus musculus
97 Nek6  
Affinity Capture-Luminescence Mus musculus
98 ARL4D  
Affinity Capture-Luminescence Mus musculus
99 Plekhb1  
Affinity Capture-Luminescence Mus musculus
100 Gna13 14674
Affinity Capture-Luminescence Mus musculus
101 Myo3a  
Affinity Capture-Luminescence Mus musculus
102 Rps27a 78294
Affinity Capture-Luminescence Mus musculus
103 DAB2 1601
Affinity Capture-Western Homo sapiens
104 Dusp10  
Affinity Capture-Luminescence Mus musculus
105 TGFBR2 7048
Two-hybrid Homo sapiens
106 SMAD7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
107 TGFBRAP1 9392
Invivo Homo sapiens
108 Arhgap15  
Affinity Capture-Luminescence Mus musculus
109 Rab13 68328
Affinity Capture-Luminescence Mus musculus
110 Fbxo3  
Affinity Capture-Luminescence Mus musculus
111 Uhmk1  
Affinity Capture-Luminescence Mus musculus
112 ENG 2022
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
113 SMURF1 57154
Affinity Capture-Western Homo sapiens
114 Irf7  
Affinity Capture-Luminescence Mus musculus
115 Nek8  
Affinity Capture-Luminescence Mus musculus
116 Fbxo34  
Affinity Capture-Luminescence Mus musculus
117 Mknk2  
Affinity Capture-Luminescence Mus musculus
118 FKBP1A 2280
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
119 Scap2  
Affinity Capture-Luminescence Mus musculus
120 Cdc20  
Affinity Capture-Luminescence Mus musculus
121 Klhl1  
Affinity Capture-Luminescence Mus musculus
122 Rasd2  
Affinity Capture-Luminescence Mus musculus
123 Rnf130 59044
Affinity Capture-Luminescence Mus musculus
124 Cdk6 12571
Affinity Capture-Luminescence Mus musculus
125 PIK3R2 5296
Invivo Homo sapiens
126 CD44 960
Reconstituted Complex Homo sapiens
127 Fkbp1a 14225
Affinity Capture-Luminescence Mus musculus
128 SMURF2 64750
Affinity Capture-Western Homo sapiens
129 PPP2R2A 5520
Invivo Homo sapiens
Invitro Homo sapiens
130 CAV1 857
Invivo Homo sapiens
Invitro Homo sapiens
131 NAA20  
Affinity Capture-Luminescence Mus musculus
132 Cul5 75717
Affinity Capture-Luminescence Mus musculus
133 Dusp6  
Affinity Capture-Luminescence Mus musculus
View the network image/svg+xml



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