Gene description for NRP1
Gene name	neuropilin 1
Gene symbol	NRP1
Other names/aliases	BDCA4 CD304 NP1 NRP VEGF165R
Species	Homo sapiens
Database cross references - NRP1
ExoCarta	ExoCarta_8829
Entrez Gene	8829
HGNC	8004
MIM	602069
UniProt	O14786
NRP1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Hepatocellular carcinoma cells	26054723
Melanoma cells	25950383
Melanoma cells	25950383
Mesenchymal stem cells	Unpublished / Not applicable
Neuroblastoma cells	25944692
Prostate cancer cells	25844599
Prostate cancer cells	25844599
Tabecular meshwork cells	21362503

Gene ontology annotations for NRP1

Molecular Function     vascular endothelial growth factor-activated receptor activity GO:0005021 NAS     cytokine binding GO:0019955 NAS     vascular endothelial growth factor binding GO:0038085 IPI     growth factor binding GO:0019838 TAS     heparin binding GO:0008201 IEA     metal ion binding GO:0046872 IEA     semaphorin receptor activity GO:0017154 NAS     protein binding GO:0005515 IPI     coreceptor activity GO:0015026 TAS Biological Process     angiogenesis GO:0001525 ISS     coronary artery morphogenesis GO:0060982 IEA     axonogenesis involved in innervation GO:0060385 ISS     patterning of blood vessels GO:0001569 ISS     vestibulocochlear nerve structural organization GO:0021649 IEA     facioacoustic ganglion development GO:1903375 IEA     platelet-derived growth factor receptor signaling pathway GO:0048008 IMP     semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285 ISS     renal artery morphogenesis GO:0061441 IEA     negative regulation of neuron apoptotic process GO:0043524 IEA     cellular response to hepatocyte growth factor stimulus GO:0035729 IMP     facial nerve structural organization GO:0021612 IEA     sympathetic ganglion development GO:0061549 ISS     regulation of vesicle-mediated transport GO:0060627 TAS     positive regulation of axon extension involved in axon guidance GO:0048842 ISS     nerve development GO:0021675 ISS     toxin transport GO:1901998 IEA     commissural neuron axon guidance GO:0071679 ISS     organ morphogenesis GO:0009887 TAS     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS     axonal fasciculation GO:0007413 IEA     response to wounding GO:0009611 IEA     regulation of retinal ganglion cell axon guidance GO:0090259 ISS     gonadotrophin-releasing hormone neuronal migration to the hypothalamus GO:0021828 IEA     positive chemotaxis GO:0050918 ISS     ganglion morphogenesis GO:0061552 IEA     endothelial cell chemotaxis GO:0035767 IMP     endothelial tip cell fate specification GO:0097102 ISS     positive regulation of retinal ganglion cell axon guidance GO:1902336 ISS     otic placode formation GO:0043049 IEA     cell-cell signaling GO:0007267 TAS     cell migration involved in sprouting angiogenesis GO:0002042 ISS     sprouting angiogenesis GO:0002040 ISS     positive regulation of endothelial cell migration GO:0010595 TAS     ventral trunk neural crest cell migration GO:0036486 IEA     branchiomotor neuron axon guidance GO:0021785 IEA     protein localization to early endosome GO:1902946 ISS     hepatocyte growth factor receptor signaling pathway GO:0048012 IMP     VEGF-activated neuropilin signaling pathway GO:0038190 ISS     neuron migration GO:0001764 ISS     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     positive regulation of cytokine activity GO:0060301 TAS     negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IEA     trigeminal ganglion development GO:0061551 IEA     artery morphogenesis GO:0048844 ISS     trigeminal nerve structural organization GO:0021637 IEA     sympathetic neuron projection extension GO:0097490 ISS     semaphorin-plexin signaling pathway GO:0071526 NAS     signal transduction GO:0007165 TAS     semaphorin-plexin signaling pathway involved in axon guidance GO:1902287 IEA     positive regulation of smooth muscle cell migration GO:0014911 TAS     axon guidance GO:0007411 TAS     angiogenesis involved in coronary vascular morphogenesis GO:0060978 ISS     axon extension involved in axon guidance GO:0048846 ISS     VEGF-activated neuropilin signaling pathway involved in axon guidance GO:1902378 IEA     dendrite development GO:0016358 IEA     neural crest cell migration involved in autonomic nervous system development GO:1901166 ISS     negative regulation of axon extension involved in axon guidance GO:0048843 IEA     positive regulation of endothelial cell proliferation GO:0001938 TAS     retina vasculature morphogenesis in camera-type eye GO:0061299 ISS     sympathetic neuron projection guidance GO:0097491 ISS     dichotomous subdivision of terminal units involved in salivary gland branching GO:0060666 IEA     sensory neuron axon guidance GO:0097374 IEA     retinal ganglion cell axon guidance GO:0031290 ISS     cellular response to vascular endothelial growth factor stimulus GO:0035924 ISS     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IMP Subcellular Localization     growth cone GO:0030426 IEA     integral component of membrane GO:0016021 IEA     plasma membrane GO:0005886 TAS     extracellular space GO:0005615 IDA     neuronal cell body GO:0043025 IEA     semaphorin receptor complex GO:0002116 NAS     focal adhesion GO:0005925 IDA     sorting endosome GO:0097443 ISS     cytoplasmic vesicle GO:0031410 TAS     cytosol GO:0005829 IDA     neurofilament GO:0005883 IEA     cell surface GO:0009986 IEA     early endosome GO:0005769 ISS     axon GO:0030424 ISS     receptor complex GO:0043235 TAS