Gene description for TNFAIP1
Gene name tumor necrosis factor, alpha-induced protein 1 (endothelial)
Gene symbol TNFAIP1
Other names/aliases B12
B61
BTBD34
EDP1
hBACURD2
Species Homo sapiens
 Database cross references - TNFAIP1
ExoCarta ExoCarta_7126
Vesiclepedia VP_7126
Entrez Gene 7126
HGNC 11894
MIM 191161
UniProt Q13829  
 TNFAIP1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TNFAIP1
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IBA
    ubiquitin-protein transferase activity GO:0004842 IDA
    protein binding GO:0005515 IPI
    cyclin binding GO:0030332 IEA
    small GTPase binding GO:0031267 IDA
    identical protein binding GO:0042802 IPI
Biological Process
    apoptotic process GO:0006915 TAS
    immune response GO:0006955 IEP
    cell migration GO:0016477 IMP
    protein ubiquitination GO:0016567 IBA
    protein ubiquitination GO:0016567 IDA
    protein ubiquitination GO:0016567 IEA
    negative regulation of Rho protein signal transduction GO:0035024 IBA
    negative regulation of Rho protein signal transduction GO:0035024 IMP
    stress fiber assembly GO:0043149 IMP
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA
    positive regulation of DNA replication GO:0045740 IEA
    protein homooligomerization GO:0051260 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IDA
    endosome GO:0005768 IDA
    cytosol GO:0005829 TAS
    Cul3-RING ubiquitin ligase complex GO:0031463 IBA
    Cul3-RING ubiquitin ligase complex GO:0031463 IDA
 Experiment description of studies that identified TNFAIP1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TNFAIP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BAG3 9531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ANLN 54443
Affinity Capture-MS Homo sapiens
3 SVIL 6840
Two-hybrid Homo sapiens
4 ZMYND19  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 USP25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 NRP1 8829
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 Mis12  
Affinity Capture-MS Mus musculus
8 TRIM54  
Two-hybrid Homo sapiens
9 PPP1CB 5500
Affinity Capture-MS Homo sapiens
10 EPM2AIP1 9852
Two-hybrid Homo sapiens
11 CSNK2B 1460
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
12 Myh9 17886
Affinity Capture-MS Mus musculus
13 KCTD13 253980
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 DVL2 1856
Affinity Capture-MS Homo sapiens
15 KIF14 9928
Affinity Capture-MS Homo sapiens
16 XPO1 7514
Affinity Capture-MS Homo sapiens
17 RIN3  
Two-hybrid Homo sapiens
18 KCTD10 83892
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 TNFAIP1 7126
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
20 UBXN7 26043
Affinity Capture-MS Homo sapiens
21 POLR1C 9533
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 ZDHHC17 23390
Two-hybrid Homo sapiens
23 STK16 8576
Two-hybrid Homo sapiens
24 BTBD9  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
25 LSM3 27258
Affinity Capture-MS Homo sapiens
26 MYO18A 399687
Affinity Capture-MS Homo sapiens
27 LIMA1 51474
Affinity Capture-MS Homo sapiens
28 HSPA1L 3305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
30 CAPZA2 830
Affinity Capture-MS Homo sapiens
31 Cul3  
Affinity Capture-MS Mus musculus
32 RBX1 9978
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
33 CAPN7 23473
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
34 COPE 11316
Affinity Capture-MS Homo sapiens
35 TUBB4A 10382
Affinity Capture-Western Homo sapiens
36 PSMA1 5682
Two-hybrid Homo sapiens
37 NXF1 10482
Affinity Capture-RNA Homo sapiens
Two-hybrid Homo sapiens
38 PCNA 5111
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
39 ARMC7  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
40 ARIH1 25820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 SYNPO 11346
Affinity Capture-MS Homo sapiens
42 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
43 CARD9 64170
Two-hybrid Homo sapiens
44 MYH9 4627
Affinity Capture-MS Homo sapiens
45 EIF4B 1975
Affinity Capture-MS Homo sapiens
46 EMC2 9694
Affinity Capture-MS Homo sapiens
47 PRKAG1 5571
Two-hybrid Homo sapiens
48 EPN3 55040
Affinity Capture-MS Homo sapiens
49 MTURN  
Affinity Capture-MS Homo sapiens
50 HEXIM2  
Two-hybrid Homo sapiens
51 ARNT 405
Two-hybrid Homo sapiens
52 EXOSC5 56915
Two-hybrid Homo sapiens
53 FLNC 2318
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 CLPSL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 WDYHV1  
Two-hybrid Homo sapiens
56 Junb  
Affinity Capture-MS Mus musculus
57 SUV39H1  
Two-hybrid Homo sapiens
58 PML 5371
Affinity Capture-MS Homo sapiens
59 RHOB 388
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
60 Copa 12847
Affinity Capture-MS Mus musculus
61 HAT1 8520
Two-hybrid Homo sapiens
62 RHOA 387
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
63 ENTHD2  
Affinity Capture-MS Homo sapiens
64 COPZ1 22818
Affinity Capture-MS Homo sapiens
65 CDC37 11140
Two-hybrid Homo sapiens
66 UBXN1 51035
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 Tpm1 22003
Affinity Capture-MS Mus musculus
68 KDM1A 23028
Two-hybrid Homo sapiens
69 FAF1 11124
Affinity Capture-MS Homo sapiens
70 Lima1  
Affinity Capture-MS Mus musculus
71 Cd2ap 12488
Affinity Capture-MS Mus musculus
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