Gene description for Cd2ap
Gene name CD2-associated protein
Gene symbol Cd2ap
Other names/aliases AL024079
C78928
METS-1
Mets1
Species Mus musculus
 Database cross references - Cd2ap
ExoCarta ExoCarta_12488
Vesiclepedia VP_12488
Entrez Gene 12488
UniProt Q9JLQ0  
 Cd2ap identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cd2ap
Molecular Function
    actin binding GO:0003779 IDA
    vascular endothelial growth factor receptor binding GO:0005172 ISO
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 ISO
    SH3 domain binding GO:0017124 IEA
    SH3 domain binding GO:0017124 ISO
    clathrin binding GO:0030276 IDA
    phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312 IDA
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    protein-containing complex binding GO:0044877 ISO
    cadherin binding GO:0045296 ISO
    actin filament binding GO:0051015 IDA
Biological Process
    immunological synapse formation GO:0001771 IMP
    kidney development GO:0001822 IDA
    kidney development GO:0001822 IMP
    liver development GO:0001889 IDA
    endothelium development GO:0003158 IMP
    protein phosphorylation GO:0006468 IMP
    lipid metabolic process GO:0006629 IDA
    apoptotic process GO:0006915 IGI
    apoptotic process GO:0006915 IMP
    inflammatory response GO:0006954 IMP
    response to oxidative stress GO:0006979 IMP
    actin filament organization GO:0007015 IBA
    actin filament organization GO:0007015 ISO
    actin filament organization GO:0007015 ISS
    cell population proliferation GO:0008283 IMP
    male gonad development GO:0008584 IMP
    protein secretion GO:0009306 IMP
    response to wounding GO:0009611 IMP
    response to virus GO:0009615 IDA
    gene expression GO:0010467 IGI
    gene expression GO:0010467 IMP
    protein transport GO:0015031 IMP
    vesicle organization GO:0016050 ISO
    cell migration GO:0016477 IBA
    cell migration GO:0016477 ISO
    actin filament polymerization GO:0030041 IMP
    cell differentiation GO:0030154 IGI
    protein catabolic process GO:0030163 IDA
    protein catabolic process GO:0030163 IMP
    neuron projection development GO:0031175 IMP
    Rab protein signal transduction GO:0032482 IMP
    glomerulus development GO:0032835 IMP
    response to insulin GO:0032868 IMP
    transforming growth factor beta1 production GO:0032905 IGI
    negative regulation of transforming growth factor beta1 production GO:0032911 IGI
    regulation of actin cytoskeleton organization GO:0032956 IGI
    maintenance of blood-brain barrier GO:0035633 IMP
    neurotrophin signaling pathway GO:0038179 IMP
    nerve growth factor signaling pathway GO:0038180 IMP
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    regulation of protein binding GO:0043393 IDA
    regulation of protein binding GO:0043393 IMP
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IGI
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IMP
    negative regulation of neuron apoptotic process GO:0043524 IDA
    cell-cell adhesion mediated by cadherin GO:0044331 IGI
    cell-cell junction organization GO:0045216 IGI
    cell-cell junction organization GO:0045216 IMP
    D-glucose import GO:0046323 IMP
    filopodium assembly GO:0046847 IMP
    neurotrophin TRK receptor signaling pathway GO:0048011 IMP
    regulation of synaptic plasticity GO:0048167 IMP
    regulation of receptor-mediated endocytosis GO:0048259 ISO
    lymph node development GO:0048535 IMP
    collateral sprouting GO:0048668 IMP
    positive regulation of protein secretion GO:0050714 IEA
    positive regulation of protein secretion GO:0050714 ISO
    synapse organization GO:0050808 IDA
    synapse organization GO:0050808 IEP
    synapse organization GO:0050808 IMP
    T cell receptor signaling pathway GO:0050852 IMP
    negative regulation of small GTPase mediated signal transduction GO:0051058 ISO
    negative regulation of small GTPase mediated signal transduction GO:0051058 ISS
    protein heterooligomerization GO:0051291 IDA
    cell division GO:0051301 IEA
    stress-activated MAPK cascade GO:0051403 IMP
    localization of cell GO:0051674 IGI
    adipose tissue development GO:0060612 IDA
    membrane organization GO:0061024 IMP
    ERK1 and ERK2 cascade GO:0070371 IGI
    response to transforming growth factor beta GO:0071559 IMP
    podocyte differentiation GO:0072112 IMP
    renal albumin absorption GO:0097018 IMP
    cell-cell adhesion GO:0098609 ISO
    positive regulation of protein localization to nucleus GO:1900182 IGI
    response to glial cell derived neurotrophic factor GO:1990790 IDA
Subcellular Localization
    fibrillar center GO:0001650 IEA
    fibrillar center GO:0001650 ISO
    ruffle GO:0001726 IEA
    ruffle GO:0001726 ISO
    podosome GO:0002102 IDA
    nuclear envelope lumen GO:0005641 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    late endosome GO:0005770 IDA
    cytosol GO:0005829 TAS
    actin filament GO:0005884 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    cell-cell junction GO:0005911 IDA
    cell cortex GO:0005938 ISO
    endocytic vesicle GO:0030139 ISO
    axon GO:0030424 IDA
    dendrite GO:0030425 IDA
    growth cone GO:0030426 IMP
    cell leading edge GO:0031252 IBA
    cell leading edge GO:0031252 ISO
    neuromuscular junction GO:0031594 IDA
    neuromuscular junction GO:0031594 IEP
    neuromuscular junction GO:0031594 IMP
    filamentous actin GO:0031941 IEA
    filamentous actin GO:0031941 ISO
    vesicle GO:0031982 IBA
    vesicle GO:0031982 IDA
    vesicle GO:0031982 IDA
    trans-Golgi network membrane GO:0032588 IDA
    protein-containing complex GO:0032991 IDA
    protein-containing complex GO:0032991 ISO
    centriolar satellite GO:0034451 IEA
    centriolar satellite GO:0034451 ISO
    slit diaphragm GO:0036057 IDA
    neuron projection GO:0043005 IMP
    perinuclear region of cytoplasm GO:0048471 ISO
    cell periphery GO:0071944 IDA
 Experiment description of studies that identified Cd2ap in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cd2ap
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CHMP2A 27243
Affinity Capture-MS Homo sapiens
2 ATP6V1B2 526
Affinity Capture-MS Homo sapiens
3 CLTC 1213
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 CLCN7 1186
Affinity Capture-MS Homo sapiens
5 MITD1 129531
Affinity Capture-MS Homo sapiens
6 KCTD10 83892
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 RACGAP1 29127
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CD2AP 23607
Affinity Capture-MS Homo sapiens
9 TSG101 7251
Affinity Capture-MS Homo sapiens
10 PHLDB1 23187
Affinity Capture-MS Homo sapiens
11 TMEM263 90488
Affinity Capture-MS Homo sapiens
12 CLTB 1212
Affinity Capture-MS Homo sapiens
13 Tmem173  
Proximity Label-MS Mus musculus
14 Flt1  
Affinity Capture-Western Mus musculus
15 CAPZB 832
Affinity Capture-MS Homo sapiens
16 RTKN2  
Affinity Capture-MS Homo sapiens
17 RNF10  
Affinity Capture-MS Homo sapiens
18 PRDX3 10935
Affinity Capture-MS Homo sapiens
19 KIF23 9493
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 AP2A1 160
Affinity Capture-MS Homo sapiens
21 CHMP5 51510
Affinity Capture-MS Homo sapiens
22 MRPL23 6150
Affinity Capture-MS Homo sapiens
23 ERC1 23085
Affinity Capture-MS Homo sapiens
24 TM9SF1 10548
Affinity Capture-MS Homo sapiens
25 CHMP2B 25978
Affinity Capture-MS Homo sapiens
26 PHLDB2 90102
Affinity Capture-MS Homo sapiens
27 SYNJ2 8871
Affinity Capture-MS Homo sapiens
28 Cbl 12402
Affinity Capture-Western Mus musculus
29 ATP6V0D1 9114
Affinity Capture-MS Homo sapiens
30 USP7 7874
Affinity Capture-MS Homo sapiens
31 NDUFS5 4725
Affinity Capture-MS Homo sapiens
32 CHMP1A 5119
Affinity Capture-MS Homo sapiens
33 TOP3B 8940
Affinity Capture-MS Homo sapiens
34 CAPZA1 829
Affinity Capture-MS Homo sapiens
35 PGAM5 192111
Affinity Capture-MS Homo sapiens
36 STOM 2040
Affinity Capture-MS Homo sapiens
37 Nphs1  
Reconstituted Complex Rattus norvegicus
38 TPD52 7163
Affinity Capture-MS Homo sapiens
39 USP8 9101
Affinity Capture-MS Homo sapiens
40 CHMP4B 128866
Affinity Capture-MS Homo sapiens
41 Arhgap21  
Co-fractionation Mus musculus
42 SHCBP1 79801
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 FLOT2 2319
Affinity Capture-MS Homo sapiens
44 Sos1  
Co-fractionation Mus musculus
45 Sorbs3  
Co-fractionation Mus musculus
46 Cask  
Affinity Capture-Western Rattus norvegicus
47 CLINT1 9685
Affinity Capture-MS Homo sapiens
48 LRRC59 55379
Affinity Capture-MS Homo sapiens
49 Sorbs2  
Co-fractionation Mus musculus
50 ERC2 26059
Affinity Capture-MS Homo sapiens
51 MYO1C 4641
Affinity Capture-MS Homo sapiens
52 PEX10  
Affinity Capture-MS Homo sapiens
53 SPTBN1 6711
Affinity Capture-MS Homo sapiens
54 IST1 9798
Affinity Capture-MS Homo sapiens
55 MYO6 4646
Affinity Capture-MS Homo sapiens
56 MYOF 26509
Affinity Capture-MS Homo sapiens
57 ATP6V1A 523
Affinity Capture-MS Homo sapiens
58 TRIM27  
Affinity Capture-MS Homo sapiens
59 SH3D19 152503
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 ATP6V0A1 535
Affinity Capture-MS Homo sapiens
61 Sorbs1  
Co-fractionation Mus musculus
62 FLOT1 10211
Affinity Capture-MS Homo sapiens
63 ARAP1 116985
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 Myo3a  
Co-fractionation Mus musculus
65 MVB12A 93343
Affinity Capture-MS Homo sapiens
66 GSN 2934
Affinity Capture-MS Homo sapiens
67 KLHL13 90293
Affinity Capture-MS Homo sapiens
68 Srgap1  
Co-fractionation Mus musculus
69 RBM45  
Affinity Capture-MS Homo sapiens
70 RPL6 6128
Affinity Capture-MS Homo sapiens
71 ERLIN1 10613
Affinity Capture-MS Homo sapiens
72 PDCD6IP 10015
Affinity Capture-MS Homo sapiens
73 TNFAIP1 7126
Affinity Capture-MS Homo sapiens
74 VPS37C 55048
Affinity Capture-MS Homo sapiens
75 Klhdc8a  
Co-fractionation Mus musculus
76 KEAP1 9817
Affinity Capture-MS Homo sapiens
77 CAPZA2 830
Affinity Capture-MS Homo sapiens
78 ITPR3 3710
Affinity Capture-MS Homo sapiens
79 DNMBP 23268
Affinity Capture-MS Homo sapiens
80 Arhgap15  
Co-fractionation Mus musculus
81 GZMB  
Biochemical Activity Homo sapiens
82 PHACTR4 65979
Affinity Capture-MS Homo sapiens
83 MICAL3 57553
Affinity Capture-MS Homo sapiens
84 DAPK3 1613
Affinity Capture-MS Homo sapiens
85 CLTA 1211
Affinity Capture-MS Homo sapiens
86 OSBPL5 114879
Affinity Capture-MS Homo sapiens
87 IFRD2 7866
Affinity Capture-MS Homo sapiens
88 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 Sh3d21  
Co-fractionation Mus musculus
90 Arhgap40  
Co-fractionation Mus musculus
91 CAV1 857
Affinity Capture-MS Homo sapiens
92 Foxp3  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Cd2ap is involved
No pathways found





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