Gene description for IFRD2
Gene name interferon-related developmental regulator 2
Gene symbol IFRD2
Other names/aliases IFNRP
SKMc15
SM15
Species Homo sapiens
 Database cross references - IFRD2
ExoCarta ExoCarta_7866
Vesiclepedia VP_7866
Entrez Gene 7866
HGNC 5457
MIM 602725
UniProt Q12894  
 IFRD2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for IFRD2
Molecular Function
    protein binding GO:0005515 IPI
    translation repressor activity GO:0030371 IDA
    ribosome binding GO:0043022 IDA
Biological Process
    negative regulation of translation GO:0017148 IDA
Subcellular Localization
    nucleus GO:0005634 HDA
 Experiment description of studies that identified IFRD2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for IFRD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NOP58 51602
Co-fractionation Homo sapiens
2 Cd2ap 12488
Affinity Capture-MS Mus musculus
3 POT1  
Two-hybrid Homo sapiens
4 E2F8  
Affinity Capture-MS Homo sapiens
5 HDAC6 10013
Affinity Capture-MS Homo sapiens
6 MDFI  
Two-hybrid Homo sapiens
7 G3BP1 10146
Affinity Capture-MS Homo sapiens
8 JRK  
Two-hybrid Homo sapiens
9 DDRGK1 65992
Affinity Capture-MS Homo sapiens
10 DRG1 4733
Co-fractionation Homo sapiens
11 DDX58 23586
Affinity Capture-RNA Homo sapiens
12 APP 351
Reconstituted Complex Homo sapiens
13 NXF1 10482
Affinity Capture-RNA Homo sapiens
14 USP36  
Affinity Capture-MS Homo sapiens
15 MOV10 4343
Affinity Capture-RNA Homo sapiens
16 EIF3J 8669
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 OGT 8473
Reconstituted Complex Homo sapiens
18 UBE2O 63893
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 Rrbp1  
Affinity Capture-MS Mus musculus
20 ENO1 2023
Affinity Capture-RNA Homo sapiens
21 NPM1 4869
Affinity Capture-MS Homo sapiens
22 Rpl35 66489
Affinity Capture-MS Mus musculus
23 ADARB1 104
Affinity Capture-MS Homo sapiens
24 PRKRA 8575
Affinity Capture-MS Homo sapiens
25 NEDD4L 23327
Reconstituted Complex Homo sapiens
26 OAS3 4940
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which IFRD2 is involved
No pathways found





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