Gene description for OGT
Gene name O-linked N-acetylglucosamine (GlcNAc) transferase
Gene symbol OGT
Other names/aliases HRNT1
Species Homo sapiens
 Database cross references - OGT
ExoCarta ExoCarta_8473
Entrez Gene 8473
HGNC 8127
MIM 300255
UniProt O15294  
 OGT identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for OGT
Molecular Function
    histone acetyltransferase activity (H4-K16 specific) GO:0046972 IDA
    acetylglucosaminyltransferase activity GO:0008375 TAS
    protein N-acetylglucosaminyltransferase activity GO:0016262 IDA
    protein O-GlcNAc transferase activity GO:0097363 ISS
    histone acetyltransferase activity (H4-K8 specific) GO:0043996 IDA
    histone acetyltransferase activity (H4-K5 specific) GO:0043995 IDA
    enzyme activator activity GO:0008047 IDA
    phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 IDA
    protein binding GO:0005515 IPI
Biological Process
    signal transduction GO:0007165 TAS
    apoptotic process GO:0006915 IDA
    positive regulation of histone H3-K4 methylation GO:0051571 IDA
    histone H3-K4 trimethylation GO:0080182 IMP
    response to insulin GO:0032868 IDA
    protein O-linked glycosylation GO:0006493 IMP
    regulation of insulin receptor signaling pathway GO:0046626 IDA
    cellular response to retinoic acid GO:0071300 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    regulation of gluconeogenesis involved in cellular glucose homeostasis GO:0090526 ISS
    positive regulation of histone H3-K27 methylation GO:0061087 IMP
    response to nutrient GO:0007584 TAS
    positive regulation of granulocyte differentiation GO:0030854 IMP
    regulation of glycolytic process GO:0006110 IDA
    phosphatidylinositol-mediated signaling GO:0048015 IDA
    chromatin organization GO:0006325 TAS
    negative regulation of protein ubiquitination GO:0031397 ISS
    circadian regulation of gene expression GO:0032922 ISS
    positive regulation of catalytic activity GO:0043085 IDA
    histone H4-K16 acetylation GO:0043984 IDA
    histone H4-K5 acetylation GO:0043981 IDA
    positive regulation of proteolysis GO:0045862 IDA
    regulation of Rac protein signal transduction GO:0035020 IDA
    histone H4-K8 acetylation GO:0043982 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytosol GO:0005829 IDA
    microtubule organizing center GO:0005815 IDA
    mitochondrion GO:0005739 IEA
    nucleoplasm GO:0005654 TAS
    histone acetyltransferase complex GO:0000123 IDA
    plasma membrane GO:0005886 IDA
    cytoplasm GO:0005737 IDA
    MLL5-L complex GO:0070688 IDA
 Experiment description of studies that identified OGT in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for OGT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FLJ20130  
Two-hybrid Homo sapiens
2 HCFC1 3054
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
3 CDK2 1017
Affinity Capture-MS Homo sapiens
4 TRAK2 66008
Invitro Homo sapiens
5 FIBP  
Affinity Capture-MS Homo sapiens
6 WDR8  
Affinity Capture-MS Homo sapiens
7 MAPT  
Invitro Homo sapiens
8 TRAK1 22906
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
9 OGT 8473
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
10 SIN3A  
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which OGT is involved
HATs acetylate histones TAS Reactome

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