Gene description for TRAK2
Gene name trafficking protein, kinesin binding 2
Gene symbol TRAK2
Other names/aliases ALS2CR3
CALS-C
GRIF-1
GRIF1
MILT2
OIP98
Species Homo sapiens
 Database cross references - TRAK2
ExoCarta ExoCarta_66008
Entrez Gene 66008
HGNC 13206
MIM 607334
UniProt O60296  
 TRAK2 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for TRAK2
Molecular Function
    GABA receptor binding GO:0050811 NAS
    receptor binding GO:0005102 ISS
    enzyme binding GO:0019899 IEA
    protein binding GO:0005515 IPI
Biological Process
    protein O-linked glycosylation GO:0006493 IEA
    protein targeting GO:0006605 IEA
    regulation of transcription from RNA polymerase II promoter GO:0006357 IEA
Subcellular Localization
    cytoplasm GO:0005737 ISS
    nucleus GO:0005634 IEA
    plasma membrane GO:0005886 ISS
    early endosome GO:0005769 IEA
    mitochondrion GO:0005739 ISS
 Experiment description of studies that identified TRAK2 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for TRAK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KCNJ2 3759
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
2 GABRB2 2561
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
3 OGT 8473
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which TRAK2 is involved
No pathways found





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