Gene description for NES
Gene name nestin
Gene symbol NES
Other names/aliases Nbla00170
Species Homo sapiens
 Database cross references - NES
ExoCarta ExoCarta_10763
Entrez Gene 10763
HGNC 7756
MIM 600915
UniProt P48681  
 NES identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for NES
Molecular Function
    molecular_function GO:0003674 ND
    structural molecule activity GO:0005198 IEA
    intermediate filament binding GO:0019215 ISS
Biological Process
    embryonic camera-type eye development GO:0031076 ISS
    G2/M transition of mitotic cell cycle GO:0000086 IDA
    stem cell proliferation GO:0072089 IMP
    negative regulation of protein binding GO:0032091 IDA
    positive regulation of neural precursor cell proliferation GO:2000179 ISS
    negative regulation of neuron apoptotic process GO:0043524 IEA
    positive regulation of intermediate filament depolymerization GO:0030844 ISS
    brain development GO:0007420 ISS
    cell projection morphogenesis GO:0048858 IEA
    central nervous system development GO:0007417 NAS
    negative regulation of catalytic activity GO:0043086 IDA
Subcellular Localization
    intermediate filament GO:0005882 NAS
    cytoplasm GO:0005737 IDA
    intermediate filament cytoskeleton GO:0045111 IDA
 Experiment description of studies that identified NES in exosomes
1
Experiment ID 193
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
PHB
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NES
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDK5 1020
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which NES is involved
No pathways found





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