Gene description for INA
Gene name internexin neuronal intermediate filament protein, alpha
Gene symbol INA
Other names/aliases NEF5
NF-66
TXBP-1
Species Homo sapiens
 Database cross references - INA
ExoCarta ExoCarta_9118
Vesiclepedia VP_9118
Entrez Gene 9118
HGNC 6057
MIM 605338
UniProt Q16352  
 INA identified in exosomes derived from the following tissue/cell type
Liver cancer cells 25265333    
 Gene ontology annotations for INA
Molecular Function
    structural constituent of cytoskeleton GO:0005200 TAS
    protein binding GO:0005515 IPI
    structural constituent of postsynaptic intermediate filament cytoskeleton GO:0099184 IBA
Biological Process
    substantia nigra development GO:0021762 HEP
    cell differentiation GO:0030154 IEA
    intermediate filament organization GO:0045109 IBA
    neurofilament cytoskeleton organization GO:0060052 IEA
    postsynaptic modulation of chemical synaptic transmission GO:0099170 IEA
    postsynaptic intermediate filament cytoskeleton organization GO:0099185 IEA
    cellular response to leukemia inhibitory factor GO:1990830 IEA
Subcellular Localization
    extracellular space GO:0005615 HDA
    cytoplasm GO:0005737 IBA
    intermediate filament GO:0005882 IBA
    neurofilament GO:0005883 IEA
    cytoplasmic ribonucleoprotein granule GO:0036464 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IEA
    postsynaptic intermediate filament cytoskeleton GO:0099160 IBA
 Experiment description of studies that identified INA in exosomes
1
Experiment ID 267
MISEV standards
Biophysical techniques
TSG101|Alix
Enriched markers
CANX|HSP90B1
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS
Authors "Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J"
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Transfected with HBx plasmids
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for INA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ECT2L  
Affinity Capture-MS Homo sapiens
2 SPRTN  
Affinity Capture-MS Homo sapiens
3 ARHGEF19  
Affinity Capture-MS Homo sapiens
4 SYCE1  
Affinity Capture-MS Homo sapiens
5 VSIG8  
Affinity Capture-MS Homo sapiens
6 FGD1  
Affinity Capture-MS Homo sapiens
7 GFAP 2670
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CCDC183  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 KIF20A 10112
Affinity Capture-MS Homo sapiens
10 BFSP2  
Affinity Capture-MS Homo sapiens
11 CAPN12  
Affinity Capture-MS Homo sapiens
12 WHAMMP3  
Affinity Capture-MS Homo sapiens
13 OBSL1 23363
Affinity Capture-MS Homo sapiens
14 KRT31 3881
Affinity Capture-MS Homo sapiens
15 KRT78 196374
Affinity Capture-MS Homo sapiens
16 BRD4 23476
Affinity Capture-MS Homo sapiens
17 KRT72 140807
Affinity Capture-MS Homo sapiens
18 TIAL1 7073
Affinity Capture-MS Homo sapiens
19 MECP2 4204
Affinity Capture-MS Homo sapiens
20 TFCP2 7024
Affinity Capture-MS Homo sapiens
21 MYCN  
Affinity Capture-MS Homo sapiens
22 SLU7  
Affinity Capture-MS Homo sapiens
23 KIF14 9928
Affinity Capture-MS Homo sapiens
24 ARHGEF11 9826
Affinity Capture-MS Homo sapiens
25 KRT8 3856
Proximity Label-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
26 CAMK2A 815
Affinity Capture-MS Homo sapiens
27 PPP1CA 5499
Affinity Capture-MS Homo sapiens
28 BAZ2B  
Affinity Capture-MS Homo sapiens
29 KRT39  
Affinity Capture-MS Homo sapiens
30 PRPH 5630
Proximity Label-MS Homo sapiens
31 RB1CC1 9821
Affinity Capture-MS Homo sapiens
32 PARK2  
Affinity Capture-MS Homo sapiens
33 CTBP1 1487
Affinity Capture-MS Homo sapiens
34 STAU1 6780
Affinity Capture-MS Homo sapiens
35 PSMD14 10213
Affinity Capture-MS Homo sapiens
36 CERS2 29956
Affinity Capture-MS Homo sapiens
37 GJB7  
Affinity Capture-MS Homo sapiens
38 CHMP4B 128866
Affinity Capture-MS Homo sapiens
39 YAP1 10413
Affinity Capture-MS Homo sapiens
40 NTRK1 4914
Affinity Capture-MS Homo sapiens
41 SYNC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 KRT14 3861
Affinity Capture-MS Homo sapiens
43 KRT2 3849
Affinity Capture-MS Homo sapiens
44 RAB11FIP5 26056
Co-fractionation Homo sapiens
45 CAPN1 823
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 GAN 8139
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 S100P 6286
Affinity Capture-MS Homo sapiens
48 MAP7 9053
Affinity Capture-MS Homo sapiens
49 VWA3B 200403
Affinity Capture-MS Homo sapiens
50 CENPP  
Affinity Capture-MS Homo sapiens
51 ECT2 1894
Affinity Capture-MS Homo sapiens
52 KRT86  
Affinity Capture-MS Homo sapiens
53 SIRT7  
Affinity Capture-MS Homo sapiens
54 CCDC120  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 KRT32  
Affinity Capture-MS Homo sapiens
56 PRMT8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 DES 1674
Affinity Capture-MS Homo sapiens
58 MAB21L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 NAP1L1 4673
Affinity Capture-MS Homo sapiens
60 KRT27 342574
Affinity Capture-MS Homo sapiens
61 ABTB2 25841
Affinity Capture-MS Homo sapiens
62 KLHL36  
Affinity Capture-MS Homo sapiens
63 NEFM 4741
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 NIN 51199
Proximity Label-MS Homo sapiens
65 DLST 1743
Affinity Capture-MS Homo sapiens
66 BICD1 636
Proximity Label-MS Homo sapiens
67 BMP1 649
Affinity Capture-MS Homo sapiens
68 KRT19 3880
Proximity Label-MS Homo sapiens
69 AKAP1 8165
Proximity Label-MS Homo sapiens
70 KRT16 3868
Affinity Capture-MS Homo sapiens
71 NES 10763
Affinity Capture-MS Homo sapiens
72 KRT18 3875
Proximity Label-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
73 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
74 ANKFY1 51479
Proximity Label-MS Homo sapiens
75 EZR 7430
Proximity Label-MS Homo sapiens
76 RSPRY1 89970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 PDHA1 5160
Affinity Capture-MS Homo sapiens
78 SQSTM1 8878
Affinity Capture-MS Homo sapiens
79 HSP90AA1 3320
Cross-Linking-MS (XL-MS) Homo sapiens
80 ERGIC1 57222
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 NEFH 4744
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 IDE 3416
Affinity Capture-MS Homo sapiens
83 ARRB1 408
Affinity Capture-MS Homo sapiens
84 CEP135  
Proximity Label-MS Homo sapiens
85 MIPEP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 KRT23  
Affinity Capture-MS Homo sapiens
87 CUL7 9820
Affinity Capture-MS Homo sapiens
88 ARHGAP23 57636
Affinity Capture-MS Homo sapiens
89 CCDC96  
Affinity Capture-MS Homo sapiens
90 MYC  
Affinity Capture-MS Homo sapiens
91 VIM 7431
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 PRMT1 3276
Affinity Capture-MS Homo sapiens
93 KRT7 3855
Affinity Capture-MS Homo sapiens
94 AIM1 202
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which INA is involved
No pathways found





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