Gene description for TIAL1
Gene name TIA1 cytotoxic granule-associated RNA binding protein-like 1
Gene symbol TIAL1
Other names/aliases TCBP
TIAR
Species Homo sapiens
 Database cross references - TIAL1
ExoCarta ExoCarta_7073
Entrez Gene 7073
HGNC 11804
MIM 603413
UniProt Q01085  
 TIAL1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for TIAL1
Molecular Function
    nucleotide binding GO:0000166 IEA
    AU-rich element binding GO:0017091 IEA
    RNA binding GO:0003723 TAS
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    defense response GO:0006952 TAS
    positive regulation of cell proliferation GO:0008284 IEA
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    apoptotic process GO:0006915 IEA
    stem cell division GO:0017145 IEA
    germ cell development GO:0007281 IEA
Subcellular Localization
    lysosome GO:0005764 TAS
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISS
    extracellular exosome GO:0070062 IDA
    cytoplasmic stress granule GO:0010494 ISS
 Experiment description of studies that identified TIAL1 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TIAL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TIAL1 is involved
No pathways found





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