Gene description for ALDH5A1
Gene name aldehyde dehydrogenase 5 family, member A1
Gene symbol ALDH5A1
Other names/aliases SSADH
SSDH
Species Homo sapiens
 Database cross references - ALDH5A1
ExoCarta ExoCarta_7915
Entrez Gene 7915
HGNC 408
MIM 610045
UniProt P51649  
 ALDH5A1 identified in exosomes derived from the following tissue/cell type
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
 Gene ontology annotations for ALDH5A1
Molecular Function
    aldehyde dehydrogenase (NAD) activity GO:0004029 IBA
    succinate-semialdehyde dehydrogenase (NAD+) activity GO:0004777 ISS
    succinate-semialdehyde dehydrogenase [NAD(P)+] activity GO:0009013 IBA
    protein homodimerization activity GO:0042803 IC
Biological Process
    glutamate metabolic process GO:0006536 ISS
    synaptic transmission GO:0007268 TAS
    neurotransmitter secretion GO:0007269 TAS
    post-embryonic development GO:0009791 IEA
    glycerophospholipid metabolic process GO:0006650 ISS
    succinate metabolic process GO:0006105 ISS
    neurotransmitter catabolic process GO:0042135 ISS
    glucosylceramide metabolic process GO:0006678 IEA
    short-chain fatty acid metabolic process GO:0046459 ISS
    glucose metabolic process GO:0006006 ISS
    acetate metabolic process GO:0006083 ISS
    galactosylceramide metabolic process GO:0006681 ISS
    respiratory electron transport chain GO:0022904 ISS
    central nervous system development GO:0007417 IMP
    protein homotetramerization GO:0051289 IDA
    gamma-aminobutyric acid catabolic process GO:0009450 IMP
    glutamine metabolic process GO:0006541 ISS
    glutathione metabolic process GO:0006749 ISS
Subcellular Localization
    mitochondrion GO:0005739 ISS
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified ALDH5A1 in exosomes
1
Experiment ID 219
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name C666-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 220
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP69
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 221
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP460
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ALDH5A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ABAT  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which ALDH5A1 is involved
PathwayEvidenceSource
Degradation of GABA TAS Reactome





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