Gene description for ADI1
Gene name acireductone dioxygenase 1
Gene symbol ADI1
Other names/aliases APL1
ARD
Fe-ARD
HMFT1638
MTCBP1
Ni-ARD
SIPL
mtnD
Species Homo sapiens
 Database cross references - ADI1
ExoCarta ExoCarta_55256
Entrez Gene 55256
HGNC 30576
MIM 613400
UniProt Q9BV57  
 ADI1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ADI1
Molecular Function
    oxidoreductase activity GO:0016491 IDA
    protein binding GO:0005515 IPI
    iron ion binding GO:0005506 IEA
    acireductone dioxygenase [iron(II)-requiring] activity GO:0010309 TAS
Biological Process
    L-methionine biosynthetic process from methylthioadenosine GO:0019509 TAS
    oxidation-reduction process GO:0055114 IEA
    polyamine metabolic process GO:0006595 TAS
    cellular nitrogen compound metabolic process GO:0034641 TAS
    small molecule metabolic process GO:0044281 TAS
    sulfur amino acid metabolic process GO:0000096 TAS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 TAS
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified ADI1 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ADI1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DBT  
Affinity Capture-MS Homo sapiens
2 OSTF1 26578
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ADI1 is involved
PathwayEvidenceSource
Methionine salvage pathway TAS Reactome





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