Gene description for TRAPPC10
Gene name trafficking protein particle complex 10
Gene symbol TRAPPC10
Other names/aliases EHOC-1
EHOC1
GT334
TMEM1
TRS130
TRS30
Species Homo sapiens
 Database cross references - TRAPPC10
ExoCarta ExoCarta_7109
Vesiclepedia VP_7109
Entrez Gene 7109
HGNC 11868
MIM 602103
UniProt P48553  
 TRAPPC10 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Thymus 23844026    
 Gene ontology annotations for TRAPPC10
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 NAS
    intra-Golgi vesicle-mediated transport GO:0006891 IBA
    intra-Golgi vesicle-mediated transport GO:0006891 IMP
    vesicle coating GO:0006901 NAS
    early endosome to Golgi transport GO:0034498 IBA
    vesicle tethering GO:0099022 NAS
Subcellular Localization
    cytoplasm GO:0005737 NAS
    cytosol GO:0005829 TAS
    TRAPP complex GO:0030008 IDA
    TRAPPII protein complex GO:1990071 IBA
    TRAPPII protein complex GO:1990071 NAS
 Experiment description of studies that identified TRAPPC10 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRAPPC10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
2 TRAPPC3L  
Two-hybrid Homo sapiens
3 TRAPPC2 6399
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RUFY4  
Affinity Capture-MS Homo sapiens
5 PDLIM7 9260
Affinity Capture-MS Homo sapiens
6 TRAPPC9 83696
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
7 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
8 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TRAPPC6B 122553
Two-hybrid Homo sapiens
10 BTBD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CRTAC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SCYL3 57147
Affinity Capture-MS Homo sapiens
13 TRAPPC5 126003
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 TRAPPC10 7109
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 KIF14 9928
Affinity Capture-MS Homo sapiens
16 CABS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 ATG9A 79065
Proximity Label-MS Homo sapiens
18 RC3H2  
Affinity Capture-MS Homo sapiens
19 ZADH2 284273
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 STMN4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 AMOTL2 51421
Affinity Capture-MS Homo sapiens
22 TBC1D14 57533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 TRAPPC8 22878
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
24 MID1IP1  
Affinity Capture-MS Homo sapiens
25 GATA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 KCNQ3  
Affinity Capture-MS Homo sapiens
27 ZNF252P-AS1  
Affinity Capture-MS Homo sapiens
28 RAB3IL1 5866
Affinity Capture-MS Homo sapiens
29 HOXB6 3216
Affinity Capture-MS Homo sapiens
30 YWHAB 7529
Affinity Capture-MS Homo sapiens
31 ADI1 55256
Affinity Capture-MS Homo sapiens
32 TRAPPC6A  
Two-hybrid Homo sapiens
33 BHLHA15  
Affinity Capture-MS Homo sapiens
34 CCDC102B  
Affinity Capture-MS Homo sapiens
35 SART1 9092
Affinity Capture-MS Homo sapiens
36 DMTN  
Affinity Capture-MS Homo sapiens
37 TRAPPC1 58485
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 ERP44 23071
Co-fractionation Homo sapiens
39 APEX1 328
Affinity Capture-RNA Homo sapiens
40 RAB43 339122
Affinity Capture-MS Homo sapiens
41 RAB30 27314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 MB21D2  
Affinity Capture-MS Homo sapiens
43 RDX 5962
Co-fractionation Homo sapiens
44 GPD2 2820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 YAP1 10413
Affinity Capture-MS Homo sapiens
46 TRAPPC4 51399
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
47 TRAPPC3 27095
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
48 RAB11A 8766
Proximity Label-MS Homo sapiens
49 TRAPPC12 51112
Two-hybrid Homo sapiens
50 TRAPPC2L 51693
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 RAB3IP  
Affinity Capture-MS Homo sapiens
52 GLB1 2720
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 CGA  
Affinity Capture-MS Homo sapiens
54 TMEM102  
Affinity Capture-MS Homo sapiens
55 KANK4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 APBA1  
Affinity Capture-MS Homo sapiens
57 BCL2L14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 YWHAG 7532
Affinity Capture-MS Homo sapiens
59 SLC31A1 1317
Affinity Capture-MS Homo sapiens
60 MTL5  
Affinity Capture-MS Homo sapiens
61 TRAPPC2B  
Affinity Capture-MS Homo sapiens
62 NOTCH1 4851
Affinity Capture-MS Homo sapiens
63 GRAMD1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 STX6 10228
Proximity Label-MS Homo sapiens
65 HUNK  
Affinity Capture-MS Homo sapiens
66 BAI1  
Affinity Capture-MS Homo sapiens
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