Gene description for TRAPPC2L
Gene name trafficking protein particle complex 2-like
Gene symbol TRAPPC2L
Other names/aliases HSPC176
Species Homo sapiens
 Database cross references - TRAPPC2L
ExoCarta ExoCarta_51693
Vesiclepedia VP_51693
Entrez Gene 51693
HGNC 30887
MIM 610970
UniProt Q9UL33  
 TRAPPC2L identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TRAPPC2L
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IBA
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 NAS
    vesicle coating GO:0006901 NAS
    COPII vesicle coating GO:0048208 NAS
    vesicle tethering GO:0099022 NAS
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 NAS
    endoplasmic reticulum GO:0005783 IEA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    TRAPP complex GO:0030008 IBA
    TRAPP complex GO:0030008 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
    TRAPPII protein complex GO:1990071 NAS
    TRAPPIII protein complex GO:1990072 NAS
 Experiment description of studies that identified TRAPPC2L in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TRAPPC2L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAPPC3L  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
2 TRAPPC6B 122553
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
3 BAG3 9531
Affinity Capture-Luminescence Homo sapiens
4 RALBP1 10928
Affinity Capture-MS Homo sapiens
5 TRIP6 7205
Two-hybrid Homo sapiens
6 PDLIM7 9260
Affinity Capture-MS Homo sapiens
7 TRAPPC9 83696
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CEP57L1  
Two-hybrid Homo sapiens
9 FASN 2194
Negative Genetic Homo sapiens
10 TRAPPC2 6399
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 BSDC1 55108
Two-hybrid Homo sapiens
12 TRAPPC5 126003
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 RAB1A 5861
Synthetic Lethality Homo sapiens
14 ZBTB42  
Two-hybrid Homo sapiens
15 CABS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 MEI4  
Two-hybrid Homo sapiens
17 STMN4  
Affinity Capture-MS Homo sapiens
18 LHX2  
Two-hybrid Homo sapiens
19 REL 5966
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
20 TRAPPC8 22878
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 BLZF1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 C7orf43  
Affinity Capture-MS Homo sapiens
23 RAB3IL1 5866
Affinity Capture-MS Homo sapiens
24 ARHGEF7 8874
Affinity Capture-MS Homo sapiens
25 C11orf68 83638
Two-hybrid Homo sapiens
26 ADI1 55256
Affinity Capture-MS Homo sapiens
27 CLUH 23277
Affinity Capture-MS Homo sapiens
28 WNT5A 7474
Affinity Capture-MS Homo sapiens
29 TRAPPC6A  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
30 RUFY4  
Affinity Capture-MS Homo sapiens
31 GAB2 9846
Affinity Capture-MS Homo sapiens
32 TRAPPC2B  
Affinity Capture-MS Homo sapiens
33 REPS2  
Affinity Capture-MS Homo sapiens
34 APP 351
Reconstituted Complex Homo sapiens
35 CMBL 134147
Affinity Capture-MS Homo sapiens
36 TRAPPC1 58485
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 Trappc8  
Affinity Capture-MS Mus musculus
38 SSX2  
Two-hybrid Homo sapiens
39 MLST8 64223
Affinity Capture-MS Homo sapiens
40 GPANK1  
Two-hybrid Homo sapiens
41 RAB43 339122
Affinity Capture-MS Homo sapiens
42 TCF4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
43 TRAPPC11 60684
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
44 CAMK2B 816
Affinity Capture-MS Homo sapiens
45 REPS1 85021
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
46 MB21D2  
Affinity Capture-MS Homo sapiens
47 TRAPPC4 51399
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 TBC1D14 57533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 TRAPPC3 27095
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
50 TRIM35 23087
Affinity Capture-MS Homo sapiens
51 TRAPPC12 51112
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 TRAPPC2L 51693
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
53 RAB3IP  
Affinity Capture-MS Homo sapiens
54 GLB1 2720
Affinity Capture-MS Homo sapiens
55 TRAPPC13 80006
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
56 MEOX2  
Two-hybrid Homo sapiens
57 TMEM102  
Affinity Capture-MS Homo sapiens
58 KRAS 3845
Synthetic Lethality Homo sapiens
59 SSX2B  
Two-hybrid Homo sapiens
60 CLPB 81570
Affinity Capture-MS Homo sapiens
61 Trappc11  
Affinity Capture-MS Mus musculus
62 BCL2L14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 MTL5  
Affinity Capture-MS Homo sapiens
64 POLR2G 5436
Two-hybrid Homo sapiens
65 GRAMD1B  
Affinity Capture-MS Homo sapiens
66 TRAPPC10 7109
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 LCN2 3934
Two-hybrid Homo sapiens
View the network image/svg+xml



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