Gene description for TRAPPC4
Gene name trafficking protein particle complex 4
Gene symbol TRAPPC4
Other names/aliases CGI-104
HSPC172
PTD009
SBDN
SYNBINDIN
TRS23
Species Homo sapiens
 Database cross references - TRAPPC4
ExoCarta ExoCarta_51399
Entrez Gene 51399
HGNC 19943
MIM 610971
UniProt Q9Y296  
 TRAPPC4 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for TRAPPC4
Molecular Function
    Rab guanyl-nucleotide exchange factor activity GO:0017112 IBA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of GTPase activity GO:0043547 IBA
    extracellular matrix organization GO:0030198 TAS
    dendrite development GO:0016358 ISS
    ER to Golgi vesicle-mediated transport GO:0006888 IBA
Subcellular Localization
    dendrite GO:0030425 ISS
    synaptic vesicle GO:0008021 ISS
    cis-Golgi network GO:0005801 IEA
    synapse GO:0045202 ISS
    Golgi stack GO:0005795 ISS
    endoplasmic reticulum GO:0005783 IEA
    TRAPP complex GO:0030008 IBA
 Experiment description of studies that identified TRAPPC4 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRAPPC4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRSS23 11098
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TRAPPC4 is involved
PathwayEvidenceSource
Syndecan interactions TAS Reactome





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