Gene description for TRAPPC11
Gene name trafficking protein particle complex 11
Gene symbol TRAPPC11
Other names/aliases C4orf41
FOIGR
GRY
LGMD2S
Species Homo sapiens
 Database cross references - TRAPPC11
ExoCarta ExoCarta_60684
Vesiclepedia VP_60684
Entrez Gene 60684
HGNC 25751
MIM 614138
UniProt Q7Z392  
 TRAPPC11 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for TRAPPC11
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IMP
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 NAS
    Golgi organization GO:0007030 IMP
    constitutive secretory pathway GO:0045054 IMP
    COPII vesicle coating GO:0048208 NAS
    regulation of protein complex stability GO:0061635 IMP
    vesicle tethering GO:0099022 NAS
Subcellular Localization
    cytoplasm GO:0005737 NAS
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 TAS
    TRAPP complex GO:0030008 IMP
    TRAPPIII protein complex GO:1990072 NAS
 Experiment description of studies that identified TRAPPC11 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRAPPC11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
2 TRAPPC3L  
Two-hybrid Homo sapiens
3 TRAPPC2 6399
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
4 RIT1 6016
Negative Genetic Homo sapiens
5 YWHAG 7532
Affinity Capture-MS Homo sapiens
6 NTRK1 4914
Affinity Capture-MS Homo sapiens
7 TRAPPC11 60684
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
8 KLC2 64837
Affinity Capture-MS Homo sapiens
9 EBAG9 9166
Proximity Label-MS Homo sapiens
10 TRAPPC5 126003
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TP53 7157
Affinity Capture-Western Homo sapiens
12 TECPR1 25851
Affinity Capture-MS Homo sapiens
13 ATG9A 79065
Proximity Label-MS Homo sapiens
14 PYGL 5836
Affinity Capture-MS Homo sapiens
15 YWHAB 7529
Affinity Capture-MS Homo sapiens
16 RACGAP1 29127
Affinity Capture-MS Homo sapiens
17 CAMSAP3  
Affinity Capture-MS Homo sapiens
18 TBC1D14 57533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 TRAPPC8 22878
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
20 ALB 213
Affinity Capture-MS Homo sapiens
21 TP63  
Affinity Capture-Western Homo sapiens
22 NR3C1 2908
Proximity Label-MS Homo sapiens
23 EGFR 1956
Negative Genetic Homo sapiens
24 TRAPPC13 80006
Affinity Capture-MS Homo sapiens
25 GAB2 9846
Affinity Capture-MS Homo sapiens
26 TP73  
Affinity Capture-Western Homo sapiens
27 CMBL 134147
Affinity Capture-MS Homo sapiens
28 TRAPPC1 58485
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 Trappc8  
Affinity Capture-MS Mus musculus
30 ARL6IP6  
Affinity Capture-MS Homo sapiens
31 RAB43 339122
Affinity Capture-MS Homo sapiens
32 MARK2 2011
Affinity Capture-MS Homo sapiens
33 TMEM132D  
Two-hybrid Homo sapiens
34 YWHAZ 7534
Affinity Capture-MS Homo sapiens
35 YWHAE 7531
Affinity Capture-MS Homo sapiens
36 BARD1 580
Two-hybrid Homo sapiens
37 TRAPPC4 51399
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
38 TRAPPC6B 122553
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 TRAPPC3 27095
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
40 TRAPPC12 51112
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
41 TRAPPC2L 51693
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
42 ZW10 9183
Co-fractionation Homo sapiens
43 YWHAQ 10971
Affinity Capture-MS Homo sapiens
44 KRAS 3845
Negative Genetic Homo sapiens
45 OTUB2  
Affinity Capture-MS Homo sapiens
46 TRAPPC2B  
Affinity Capture-MS Homo sapiens
47 BAIAP2 10458
Affinity Capture-MS Homo sapiens
48 APPL1 26060
Affinity Capture-MS Homo sapiens
49 PTAR1 375743
Synthetic Lethality Homo sapiens
50 KLHL14 57565
Affinity Capture-MS Homo sapiens
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