Gene description for KLHL14
Gene name kelch-like family member 14
Gene symbol KLHL14
Other names/aliases -
Species Homo sapiens
 Database cross references - KLHL14
ExoCarta ExoCarta_57565
Vesiclepedia VP_57565
Entrez Gene 57565
HGNC 29266
MIM 613772
UniProt Q9P2G3  
 KLHL14 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for KLHL14
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    cytosol GO:0005829 IDA
    actin cytoskeleton GO:0015629 IDA
    aggresome GO:0016235 IDA
    neuron projection GO:0043005 IBA
    neuronal cell body GO:0043025 IBA
 Experiment description of studies that identified KLHL14 in sEVs
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KLHL14
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KLHL9 55958
Affinity Capture-MS Homo sapiens
2 PEX6  
Affinity Capture-MS Homo sapiens
3 HERC1 8925
Affinity Capture-MS Homo sapiens
4 MTR 4548
Affinity Capture-MS Homo sapiens
5 NEU3  
Affinity Capture-MS Homo sapiens
6 KLHL13 90293
Affinity Capture-MS Homo sapiens
7 KLHL28  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 WDR6 11180
Affinity Capture-MS Homo sapiens
9 KLHL15  
Affinity Capture-MS Homo sapiens
10 TRAPPC11 60684
Affinity Capture-MS Homo sapiens
11 PPP2R5E 5529
Affinity Capture-MS Homo sapiens
12 ZNFX1 57169
Affinity Capture-MS Homo sapiens
13 TOR1A 1861
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-localization Homo sapiens
14 PPP2R5D 5528
Affinity Capture-MS Homo sapiens
15 ARHGAP35 2909
Affinity Capture-MS Homo sapiens
16 CPNE7 27132
Affinity Capture-MS Homo sapiens
17 SMG8 55181
Affinity Capture-MS Homo sapiens
18 ZBTB24  
Affinity Capture-MS Homo sapiens
19 BBS7 55212
Affinity Capture-MS Homo sapiens
20 KLHL26  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 IQGAP3 128239
Affinity Capture-MS Homo sapiens
22 ARHGEF10 9639
Affinity Capture-MS Homo sapiens
23 MISP 126353
Affinity Capture-MS Homo sapiens
24 NUDCD3 23386
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SPATA5L1 79029
Affinity Capture-MS Homo sapiens
26 IFT122 55764
Affinity Capture-MS Homo sapiens
27 BBS2 583
Affinity Capture-MS Homo sapiens
28 DBNL 28988
Affinity Capture-MS Homo sapiens
29 TOP3B 8940
Affinity Capture-MS Homo sapiens
30 ARHGAP32  
Affinity Capture-MS Homo sapiens
31 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
32 TSEN15 116461
Affinity Capture-MS Homo sapiens
33 SBF1 6305
Affinity Capture-MS Homo sapiens
34 IPP  
Affinity Capture-MS Homo sapiens
35 TTC1 7265
Affinity Capture-MS Homo sapiens
36 TUBA1A 7846
Affinity Capture-MS Homo sapiens
37 BTBD7  
Affinity Capture-MS Homo sapiens
38 PAX5  
Affinity Capture-MS Homo sapiens
39 TANGO6 79613
Affinity Capture-MS Homo sapiens
40 EIF2AK4 440275
Affinity Capture-MS Homo sapiens
41 PASK  
Affinity Capture-MS Homo sapiens
42 ALG3 10195
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 MYO10 4651
Affinity Capture-MS Homo sapiens
44 KLHL24  
Affinity Capture-MS Homo sapiens
45 CBWD3  
Affinity Capture-MS Homo sapiens
46 TRAPPC8 22878
Affinity Capture-MS Homo sapiens
47 KLHL22 84861
Affinity Capture-MS Homo sapiens
48 DDX28  
Affinity Capture-MS Homo sapiens
49 HJURP  
Affinity Capture-MS Homo sapiens
50 CUL7 9820
Affinity Capture-MS Homo sapiens
51 KCTD21 283219
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 KBTBD4  
Affinity Capture-MS Homo sapiens
53 CCZ1 51622
Affinity Capture-MS Homo sapiens
54 PPP2R5A 5525
Affinity Capture-MS Homo sapiens
55 TEP1 7011
Affinity Capture-MS Homo sapiens
56 FLAD1 80308
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 IGHV4-31 28396
Affinity Capture-MS Homo sapiens
58 ARAF 369
Affinity Capture-MS Homo sapiens
59 FBXL17  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 KLHL21 9903
Affinity Capture-MS Homo sapiens
61 SARDH 1757
Affinity Capture-MS Homo sapiens
62 PPP2R5B 5526
Affinity Capture-MS Homo sapiens
63 TAF6L 10629
Affinity Capture-MS Homo sapiens
64 TCP11L1 55346
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KLHL14 is involved
No pathways found





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