Gene description for ZNFX1
Gene name zinc finger, NFX1-type containing 1
Gene symbol ZNFX1
Other names/aliases -
Species Homo sapiens
 Database cross references - ZNFX1
ExoCarta ExoCarta_57169
Vesiclepedia VP_57169
Entrez Gene 57169
HGNC 29271
UniProt Q9P2E3  
 ZNFX1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ZNFX1
Molecular Function
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IBA
    helicase activity GO:0004386 IEA
    zinc ion binding GO:0008270 IEA
Biological Process
    activation of innate immune response GO:0002218 ISS
    regulatory ncRNA-mediated heterochromatin formation GO:0031048 IBA
    defense response to bacterium GO:0042742 IMP
    negative regulation of viral genome replication GO:0045071 ISS
    innate immune response GO:0045087 IEA
    defense response to virus GO:0051607 IMP
Subcellular Localization
    mitochondrial outer membrane GO:0005741 ISS
    cytoplasmic stress granule GO:0010494 IDA
    nuclear RNA-directed RNA polymerase complex GO:0031380 IBA
 Experiment description of studies that identified ZNFX1 in sEVs
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ZNFX1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MIEF1  
Affinity Capture-MS Homo sapiens
2 MAP2K2 5605
Affinity Capture-MS Homo sapiens
3 FAM167A  
Affinity Capture-MS Homo sapiens
4 AMZ2  
Affinity Capture-MS Homo sapiens
5 FBXW5  
Affinity Capture-MS Homo sapiens
6 MRPS17 51373
Affinity Capture-MS Homo sapiens
7 DVL2 1856
Affinity Capture-MS Homo sapiens
8 CIB2  
Affinity Capture-MS Homo sapiens
9 UGGT1 56886
Affinity Capture-MS Homo sapiens
10 PCDH1 5097
Affinity Capture-MS Homo sapiens
11 BAG2 9532
Affinity Capture-MS Homo sapiens
12 DNAJA2 10294
Affinity Capture-MS Homo sapiens
13 PDK1 5163
Affinity Capture-MS Homo sapiens
14 AURKA 6790
Affinity Capture-MS Homo sapiens
15 SULT1C4  
Affinity Capture-MS Homo sapiens
16 SS18L2  
Affinity Capture-MS Homo sapiens
17 CUL3 8452
Affinity Capture-MS Homo sapiens
18 NR3C1 2908
Proximity Label-MS Homo sapiens
19 LACTB 114294
Affinity Capture-MS Homo sapiens
20 SHMT2 6472
Affinity Capture-RNA Homo sapiens
21 B4GALT2  
Affinity Capture-MS Homo sapiens
22 OS9 10956
Affinity Capture-MS Homo sapiens
23 DDX58 23586
Affinity Capture-RNA Homo sapiens
24 NXF1 10482
Affinity Capture-RNA Homo sapiens
25 HSF2  
Affinity Capture-MS Homo sapiens
26 STRAP 11171
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 PURG  
Affinity Capture-MS Homo sapiens
28 CXXC4 80319
Affinity Capture-MS Homo sapiens
29 XPO1 7514
Affinity Capture-MS Homo sapiens
30 CRYBB3  
Affinity Capture-MS Homo sapiens
31 Hsph1 15505
Affinity Capture-MS Mus musculus
32 DROSHA  
Affinity Capture-MS Homo sapiens
33 MOV10 4343
Affinity Capture-RNA Homo sapiens
34 TUBA1C 84790
Affinity Capture-MS Homo sapiens
35 FYN 2534
Affinity Capture-MS Homo sapiens
36 CTAG1B  
Affinity Capture-MS Homo sapiens
37 CDK4 1019
Affinity Capture-MS Homo sapiens
38 TRIM31  
Affinity Capture-MS Homo sapiens
39 IMP3 55272
Affinity Capture-MS Homo sapiens
40 SCAF11  
Affinity Capture-MS Homo sapiens
41 ENO1 2023
Affinity Capture-RNA Homo sapiens
42 SF3B3 23450
Affinity Capture-MS Homo sapiens
43 DRC1  
Affinity Capture-MS Homo sapiens
44 CSDE1 7812
Affinity Capture-MS Homo sapiens
45 Ptbp1 19205
Affinity Capture-MS Mus musculus
46 TMEM55B 90809
Affinity Capture-MS Homo sapiens
47 DDX27 55661
Affinity Capture-MS Homo sapiens
48 RBMS2 5939
Affinity Capture-MS Homo sapiens
49 UBXN6 80700
Affinity Capture-MS Homo sapiens
50 UPP1 7378
Affinity Capture-MS Homo sapiens
51 KLHL14 57565
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZNFX1 is involved
No pathways found





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