Gene description for MAP2K2
Gene name	mitogen-activated protein kinase kinase 2
Gene symbol	MAP2K2
Other names/aliases	CFC4 MAPKK2 MEK2 MKK2 PRKMK2
Species	Homo sapiens
Database cross references - MAP2K2
ExoCarta	ExoCarta_5605
Entrez Gene	5605
HGNC	6842
MIM	601263
UniProt	P36507
MAP2K2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Thymus	23844026

Gene ontology annotations for MAP2K2

Molecular Function     protein serine/threonine/tyrosine kinase activity GO:0004712 TAS     protein tyrosine kinase activity GO:0004713 IEA     protein serine/threonine kinase activity GO:0004674 TAS     MAP kinase kinase activity GO:0004708 IDA     scaffold protein binding GO:0097110 IPI     PDZ domain binding GO:0030165 IDA     protein binding GO:0005515 IPI     protein complex scaffold GO:0032947 IEA     protein serine/threonine kinase activator activity GO:0043539 IDA     ATP binding GO:0005524 IEA Biological Process     small GTPase mediated signal transduction GO:0007264 TAS     positive regulation of protein serine/threonine kinase activity GO:0071902 IDA     Ras protein signal transduction GO:0007265 TAS     innate immune response GO:0045087 TAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     regulation of early endosome to late endosome transport GO:2000641 TAS     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     toll-like receptor 2 signaling pathway GO:0034134 TAS     peptidyl-serine autophosphorylation GO:0036289 IDA     toll-like receptor 4 signaling pathway GO:0034142 TAS     stress-activated MAPK cascade GO:0051403 TAS     axon guidance GO:0007411 TAS     toll-like receptor 10 signaling pathway GO:0034166 TAS     regulation of Golgi inheritance GO:0090170 TAS     toll-like receptor 5 signaling pathway GO:0034146 TAS     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     peptidyl-tyrosine phosphorylation GO:0018108 IEA     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     toll-like receptor signaling pathway GO:0002224 TAS     toll-like receptor 3 signaling pathway GO:0034138 TAS     regulation of stress-activated MAPK cascade GO:0032872 TAS     positive regulation of cell motility GO:2000147 IEA     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     toll-like receptor 9 signaling pathway GO:0034162 TAS     activation of MAPKK activity GO:0000186 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     MAPK cascade GO:0000165 TAS     ERK1 and ERK2 cascade GO:0070371 TAS     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     insulin receptor signaling pathway GO:0008286 TAS     activation of MAPK activity GO:0000187 TAS Subcellular Localization     extracellular region GO:0005576 NAS     nucleus GO:0005634 TAS     cytosol GO:0005829 TAS     Golgi apparatus GO:0005794 TAS     focal adhesion GO:0005925 TAS     late endosome GO:0005770 TAS     mitochondrion GO:0005739 TAS     cytoplasm GO:0005737 IDA     cell-cell junction GO:0005911 IDA     peroxisomal membrane GO:0005778 IDA     microtubule GO:0005874 IDA     cytoplasmic side of plasma membrane GO:0009898 IDA     endoplasmic reticulum GO:0005783 IDA     early endosome GO:0005769 TAS     cell cortex GO:0005938 IEA     perinuclear region of cytoplasm GO:0048471 IDA     intracellular GO:0005622 IBA