Gene description for CEP170
Gene name centrosomal protein 170kDa
Gene symbol CEP170
Other names/aliases FAM68A
KAB
KIAA0470
Species Homo sapiens
 Database cross references - CEP170
ExoCarta ExoCarta_9859
Vesiclepedia VP_9859
Entrez Gene 9859
HGNC 28920
MIM 613023
UniProt Q5SW79  
 CEP170 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
 Gene ontology annotations for CEP170
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    centrosome GO:0005813 IDA
    centriole GO:0005814 IBA
    centriole GO:0005814 IDA
    spindle GO:0005819 IEA
    cytosol GO:0005829 IDA
    microtubule GO:0005874 IEA
    centriolar subdistal appendage GO:0120103 IDA
 Experiment description of studies that identified CEP170 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CEP170
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kif19a  
Affinity Capture-MS Mus musculus
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 SMC3 9126
Affinity Capture-MS Homo sapiens
4 CEP250 11190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 VTI1B 10490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 KIFC3 3801
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 BEGAIN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 YWHAE 7531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TRIM66  
Affinity Capture-MS Homo sapiens
10 UBA1 7317
Cross-Linking-MS (XL-MS) Homo sapiens
11 PPP2R3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 MAP4 4134
Affinity Capture-MS Homo sapiens
13 UBE3A 7337
Affinity Capture-MS Homo sapiens
14 USP9X 8239
Affinity Capture-MS Homo sapiens
15 CCDC151  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 SYNE2 23224
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 CBY1  
Affinity Capture-MS Homo sapiens
19 ARL6IP1 23204
Cross-Linking-MS (XL-MS) Homo sapiens
20 SOX2  
Affinity Capture-MS Homo sapiens
21 FRAT2  
Affinity Capture-MS Homo sapiens
22 WDR62  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 KIF20A 10112
Affinity Capture-MS Homo sapiens
24 MRFAP1L1  
Affinity Capture-MS Homo sapiens
25 S100A4 6275
Affinity Capture-MS Homo sapiens
26 EMILIN1 11117
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 B3GNT2 10678
Affinity Capture-MS Homo sapiens
28 KIF23 9493
Affinity Capture-MS Homo sapiens
29 RAB3IP  
Affinity Capture-MS Homo sapiens
30 Cep55 74107
Affinity Capture-MS Mus musculus
31 FBXW7  
Affinity Capture-MS Homo sapiens
32 STX8 9482
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 Cep170  
Affinity Capture-MS Mus musculus
34 Fgfr1op  
Affinity Capture-MS Mus musculus
35 Ankrd26  
Affinity Capture-MS Mus musculus
36 OIP5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 Cenpe  
Affinity Capture-MS Mus musculus
38 HERC2 8924
Affinity Capture-MS Homo sapiens
39 KIF2C 11004
Affinity Capture-MS Homo sapiens
40 YWHAH 7533
Affinity Capture-MS Homo sapiens
41 ATG16L1 55054
Affinity Capture-MS Homo sapiens
42 CEP57  
Affinity Capture-MS Homo sapiens
43 VPS53 55275
Affinity Capture-MS Homo sapiens
44 MECP2 4204
Affinity Capture-MS Homo sapiens
45 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 MYCN  
Affinity Capture-MS Homo sapiens
47 KNSTRN  
Affinity Capture-MS Homo sapiens
48 CSNK2B 1460
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 KIF3A 11127
Affinity Capture-MS Homo sapiens
50 Cep120  
Affinity Capture-MS Mus musculus
51 KIF14 9928
Affinity Capture-MS Homo sapiens
52 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 AGO2 27161
Affinity Capture-MS Homo sapiens
54 C1orf106  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 Fam83d  
Affinity Capture-MS Mus musculus
56 SPAG5 10615
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 PPP1CA 5499
Two-hybrid Homo sapiens
58 HAUS2  
Affinity Capture-MS Homo sapiens
59 TNKS 8658
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 TEKT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 C9orf78 51759
Affinity Capture-MS Homo sapiens
62 RB1CC1 9821
Affinity Capture-MS Homo sapiens
63 CCAR2 57805
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 FAM9C  
Affinity Capture-MS Homo sapiens
65 MAPRE1 22919
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 TRIM10  
Affinity Capture-MS Homo sapiens
67 CHMP4B 128866
Affinity Capture-MS Homo sapiens
68 BTF3 689
Affinity Capture-MS Homo sapiens
69 NTRK1 4914
Affinity Capture-MS Homo sapiens
70 DCAF7 10238
Affinity Capture-MS Homo sapiens
71 PNMA2  
Affinity Capture-MS Homo sapiens
72 DCTN1 1639
Proximity Label-MS Homo sapiens
73 NELL2  
Affinity Capture-MS Homo sapiens
74 YWHAQ 10971
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
75 RPA4  
Proximity Label-MS Homo sapiens
76 APBA1  
Affinity Capture-MS Homo sapiens
77 HECTD1 25831
Affinity Capture-MS Homo sapiens
78 VAV2 7410
Two-hybrid Homo sapiens
79 Cdk5rap2  
Affinity Capture-MS Mus musculus
80 CEBPA  
Protein-peptide Homo sapiens
81 FGFR1OP  
Affinity Capture-MS Homo sapiens
82 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
83 NEURL4  
Affinity Capture-MS Homo sapiens
84 ANLN 54443
Affinity Capture-MS Homo sapiens
85 PHLPP1  
Proximity Label-MS Homo sapiens
86 DISC1 27185
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
87 DAPK3 1613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 VAMP8 8673
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 XPO1 7514
Affinity Capture-MS Homo sapiens
90 BAG2 9532
Affinity Capture-MS Homo sapiens
91 ECT2 1894
Affinity Capture-MS Homo sapiens
92 SIRT7  
Affinity Capture-MS Homo sapiens
93 CCDC120  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 AKAP9 10142
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 HERC2P9  
Affinity Capture-MS Homo sapiens
96 MIS18A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 INPP5E 56623
Affinity Capture-MS Homo sapiens
98 PHIP 55023
Affinity Capture-MS Homo sapiens
99 CUL3 8452
Affinity Capture-MS Homo sapiens
100 YWHAZ 7534
Affinity Capture-MS Homo sapiens
101 TUBB4B 10383
Affinity Capture-MS Homo sapiens
102 EGFR 1956
Affinity Capture-MS Homo sapiens
103 MAP2K2 5605
Affinity Capture-MS Homo sapiens
104 Grasp  
Two-hybrid Rattus norvegicus
105 AURKB 9212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 MAPRE3  
Proximity Label-MS Homo sapiens
107 RPA3 6119
Proximity Label-MS Homo sapiens
108 MAPK6  
Affinity Capture-MS Homo sapiens
109 Cep72  
Affinity Capture-MS Mus musculus
110 ANGPT4  
Affinity Capture-MS Homo sapiens
111 MYC  
Affinity Capture-MS Homo sapiens
112 Uso1 56041
Affinity Capture-MS Mus musculus
113 NIN 51199
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 CEP170B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
116 PKD2 5311
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 RPSA 3921
Cross-Linking-MS (XL-MS) Homo sapiens
118 RFWD3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 DDRGK1 65992
Affinity Capture-MS Homo sapiens
120 Rpl35 66489
Affinity Capture-MS Mus musculus
121 CCDC6 8030
Affinity Capture-MS Homo sapiens
122 Prkar2a 19087
Affinity Capture-MS Mus musculus
123 KIF2B 84643
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 Prkacb 18749
Affinity Capture-MS Mus musculus
125 FARP1 10160
Affinity Capture-MS Homo sapiens
126 CCDC8  
Affinity Capture-MS Homo sapiens
127 SURF6  
Affinity Capture-MS Homo sapiens
128 KIF2A 3796
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 CCDC68  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 SIRT6  
Affinity Capture-MS Homo sapiens
131 PARP1 142
Proximity Label-MS Homo sapiens
132 CEP170P1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
133 TFPT  
Affinity Capture-MS Homo sapiens
134 DSTYK 25778
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 Cep135  
Affinity Capture-MS Mus musculus
136 TUBGCP3 10426
Affinity Capture-MS Homo sapiens
137 PRKACA 5566
Affinity Capture-MS Homo sapiens
138 PCYT1A 5130
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 CAPZB 832
Affinity Capture-MS Homo sapiens
140 SNAPIN 23557
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 C15orf59  
Affinity Capture-MS Homo sapiens
142 KIFAP3 22920
Affinity Capture-MS Homo sapiens
143 Kifc3  
Affinity Capture-MS Mus musculus
144 PRKAR2B 5577
Affinity Capture-MS Homo sapiens
145 Lrrcc1  
Affinity Capture-MS Mus musculus
146 UFL1 23376
Affinity Capture-MS Homo sapiens
147 RUFY2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 TRIM37  
Proximity Label-MS Homo sapiens
149 NCL 4691
Affinity Capture-MS Homo sapiens
150 Kif4  
Affinity Capture-MS Mus musculus
151 ASB7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 CPN1 1369
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
153 NDEL1 81565
Two-hybrid Homo sapiens
154 CORO1B 57175
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
155 PDE4DIP 9659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
156 CCDC136  
Affinity Capture-MS Homo sapiens
157 NHSL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
158 PSPC1 55269
Affinity Capture-MS Homo sapiens
159 RPA2 6118
Proximity Label-MS Homo sapiens
160 PRMT1 3276
Affinity Capture-MS Homo sapiens
161 LUC7L3 51747
Co-fractionation Homo sapiens
162 C17orf59 54785
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CEP170 is involved
No pathways found





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