Gene description for UBE3A
Gene name ubiquitin protein ligase E3A
Gene symbol UBE3A
Other names/aliases ANCR
AS
E6-AP
EPVE6AP
HPVE6A
Species Homo sapiens
 Database cross references - UBE3A
ExoCarta ExoCarta_7337
Vesiclepedia VP_7337
Entrez Gene 7337
HGNC 12496
MIM 601623
UniProt Q05086  
 UBE3A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for UBE3A
Molecular Function
    transcription coactivator activity GO:0003713 IEA
    ubiquitin-protein transferase activity GO:0004842 IDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 IDA
    ubiquitin protein ligase activity GO:0061630 IMP
Biological Process
    protein polyubiquitination GO:0000209 IBA
    ovarian follicle development GO:0001541 IEA
    proteolysis GO:0006508 TAS
    ubiquitin-dependent protein catabolic process GO:0006511 TAS
    brain development GO:0007420 TAS
    androgen receptor signaling pathway GO:0030521 IEA
    positive regulation of protein ubiquitination GO:0031398 IDA
    response to progesterone GO:0032570 IDA
    sperm entry GO:0035037 IEA
    locomotory exploration behavior GO:0035641 IEA
    response to cocaine GO:0042220 IEA
    response to hydrogen peroxide GO:0042542 IEA
    regulation of circadian rhythm GO:0042752 IMP
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    regulation of synaptic plasticity GO:0048167 ISS
    rhythmic process GO:0048511 IEA
    progesterone receptor signaling pathway GO:0050847 IDA
    protein autoubiquitination GO:0051865 IDA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA
    prostate gland growth GO:0060736 IEA
    negative regulation of dendritic spine morphogenesis GO:0061002 IEA
    motor learning GO:0061743 IEA
    protein K48-linked ubiquitination GO:0070936 IDA
    negative regulation of TORC1 signaling GO:1904262 ISS
    positive regulation of Golgi lumen acidification GO:1905528 IEA
    cellular response to brain-derived neurotrophic factor stimulus GO:1990416 IEA
    regulation of ubiquitin-dependent protein catabolic process GO:2000058 IBA
    regulation of ubiquitin-dependent protein catabolic process GO:2000058 IMP
Subcellular Localization
    proteasome complex GO:0000502 IEA
    nucleus GO:0005634 IEA
    cytosol GO:0005829 IBA
    synaptic vesicle GO:0008021 IEA
    glutamatergic synapse GO:0098978 IEA
    postsynaptic cytosol GO:0099524 IEA
 Experiment description of studies that identified UBE3A in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for UBE3A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 OR2M7  
Affinity Capture-MS Homo sapiens
2 APP 351
Reconstituted Complex Homo sapiens
3 PSMA6 5687
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 TUBB2B 347733
Affinity Capture-MS Homo sapiens
5 CEP170 9859
Affinity Capture-MS Homo sapiens
6 MCM7 4176
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 HSPA5 3309
Reconstituted Complex Homo sapiens
8 RAP1GAP 5909
Affinity Capture-Western Homo sapiens
9 SENP3 26168
Affinity Capture-MS Homo sapiens
10 UTRN 7402
Co-fractionation Homo sapiens
11 NPLOC4 55666
Co-fractionation Homo sapiens
12 KRT6B 3854
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
13 KRT1 3848
Reconstituted Complex Homo sapiens
14 Psmb5 19173
Affinity Capture-MS Mus musculus
15 FAM167A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ZFAND2B  
Affinity Capture-MS Homo sapiens
17 TSC2 7249
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
18 ATG9A 79065
Two-hybrid Homo sapiens
19 PKM 5315
Reconstituted Complex Homo sapiens
20 SRPRB 58477
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 PSMD11 5717
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 RPA2 6118
Proximity Label-MS Homo sapiens
23 RPL7 6129
Affinity Capture-MS Homo sapiens
24 E2F1 1869
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
25 MNT  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
26 GFAP 2670
Reconstituted Complex Homo sapiens
27 BRCA1 672
Reconstituted Complex Homo sapiens
28 MAGEA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 UBE3A 7337
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
30 USP16  
Affinity Capture-MS Homo sapiens
31 UBC 7316
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
32 HSP90AB1 3326
Reconstituted Complex Homo sapiens
33 EIF4A1 1973
Affinity Capture-MS Homo sapiens
34 PGR  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
35 ZFAND5 7763
Affinity Capture-MS Homo sapiens
36 PSMD10 5716
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 ACTB 60
Reconstituted Complex Homo sapiens
38 CCDC92  
Affinity Capture-MS Homo sapiens
39 AFTPH  
Two-hybrid Homo sapiens
40 VASP 7408
Affinity Capture-MS Homo sapiens
41 ARNTL  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
42 KDELR1 10945
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 HAL 3034
Affinity Capture-MS Homo sapiens
44 CKB 1152
Reconstituted Complex Homo sapiens
45 PIPSL 266971
Affinity Capture-MS Homo sapiens
46 CCDC74A  
Affinity Capture-MS Homo sapiens
47 TCF19  
Two-hybrid Homo sapiens
48 S100A4 6275
Affinity Capture-MS Homo sapiens
49 NOMO2 283820
Two-hybrid Homo sapiens
50 YWHAZ 7534
Two-hybrid Homo sapiens
51 HSPA2 3306
Reconstituted Complex Homo sapiens
52 OR6T1  
Affinity Capture-MS Homo sapiens
53 MCM2 4171
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
54 ENO2 2026
Reconstituted Complex Homo sapiens
55 COPS6 10980
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
56 NUMBL 9253
Reconstituted Complex Homo sapiens
57 PIGF  
Affinity Capture-MS Homo sapiens
58 ANKRD49  
Affinity Capture-MS Homo sapiens
59 SCRIB 23513
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
60 PSMD12 5718
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 PARVA 55742
Two-hybrid Homo sapiens
62 PSMB6 5694
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 PSMC6 5706
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 PHKG1  
Affinity Capture-MS Homo sapiens
65 NCOA3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
66 PSMC2 5701
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 UBQLN1 29979
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
68 LPP 4026
Co-fractionation Homo sapiens
69 RNASE7 84659
Affinity Capture-MS Homo sapiens
70 LCN2 3934
Reconstituted Complex Homo sapiens
71 C2orf44  
Affinity Capture-MS Homo sapiens
72 LRSAM1 90678
Co-fractionation Homo sapiens
73 HERC2 8924
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 SLMO1  
Affinity Capture-MS Homo sapiens
75 PDIA6 10130
Reconstituted Complex Homo sapiens
76 UCHL5 51377
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 P3H1 64175
Co-fractionation Homo sapiens
78 ASAP3 55616
Two-hybrid Homo sapiens
79 TUBB 203068
Reconstituted Complex Homo sapiens
80 RXFP1  
Affinity Capture-MS Homo sapiens
81 PSMD5 5711
Affinity Capture-MS Homo sapiens
82 CALR 811
Reconstituted Complex Homo sapiens
83 NR4A3  
Two-hybrid Homo sapiens
84 AFG3L1P  
Two-hybrid Homo sapiens
85 SNX27 81609
Affinity Capture-MS Homo sapiens
86 PSMD6 9861
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 PPIA 5478
Reconstituted Complex Homo sapiens
88 TMEM136  
Affinity Capture-MS Homo sapiens
89 PSAP 5660
Two-hybrid Homo sapiens
90 FAF2 23197
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
91 PPP1R3F  
Reconstituted Complex Homo sapiens
92 ARHGEF15  
Affinity Capture-Western Homo sapiens
93 HPCAL4  
Two-hybrid Homo sapiens
94 LSM1 27257
Co-fractionation Homo sapiens
95 RAD23A 5886
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
96 GSK3B 2932
Affinity Capture-Western Homo sapiens
97 ARHGDIB 397
Reconstituted Complex Homo sapiens
98 HSPA8 3312
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
99 HAT1 8520
Co-fractionation Homo sapiens
100 EIF3C 8663
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 PTPN3  
Affinity Capture-MS Homo sapiens
102 UNC45A 55898
Co-fractionation Homo sapiens
103 MCM6 4175
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
104 CALM2 805
Affinity Capture-MS Homo sapiens
105 TBC1D14 57533
Two-hybrid Homo sapiens
106 MDM1  
Reconstituted Complex Homo sapiens
107 NSUN2 54888
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 RAD23B 5887
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
109 IPO11 51194
Co-fractionation Homo sapiens
110 PHKA2 5256
Affinity Capture-MS Homo sapiens
111 TMEM14B  
Two-hybrid Homo sapiens
112 KRT5 3852
Reconstituted Complex Homo sapiens
113 DBNL 28988
Co-fractionation Homo sapiens
114 PSMB4 5692
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 ACTR3 10096
Reconstituted Complex Homo sapiens
116 USP14 9097
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
117 PSMD4 5710
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Co-fractionation Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
118 PSMA4 5685
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 ALDH1A2 8854
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
120 MTAP 4507
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 BTF3L4 91408
Co-fractionation Homo sapiens
122 PSMC1 5700
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 PSMD14 10213
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 PSMB1 5689
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 SCAMP1 9522
Two-hybrid Homo sapiens
126 DAZAP2  
Two-hybrid Homo sapiens
127 C12orf49  
Positive Genetic Homo sapiens
128 PTCD3 55037
Two-hybrid Homo sapiens
129 HIF1AN 55662
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 MDM2  
Biochemical Activity Homo sapiens
131 AWAT2  
Affinity Capture-MS Homo sapiens
132 BBS1 582
Affinity Capture-MS Homo sapiens
133 BARD1 580
Reconstituted Complex Homo sapiens
134 NTRK1 4914
Affinity Capture-MS Homo sapiens
135 UBQLN2 29978
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
136 KRT9 3857
Reconstituted Complex Homo sapiens
137 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
138 CRP  
Two-hybrid Homo sapiens
139 LCN1 3933
Affinity Capture-MS Homo sapiens
140 MEOX2  
Two-hybrid Homo sapiens
141 CELA2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 TUBA1B 10376
Affinity Capture-MS Homo sapiens
143 PML 5371
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
144 UBE2D3 7323
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
145 UBE2L6 9246
Biochemical Activity Homo sapiens
FRET Homo sapiens
146 PAX5  
Two-hybrid Homo sapiens
147 COPS7B 64708
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 C11orf49  
Two-hybrid Homo sapiens
149 DDX39B 7919
Co-fractionation Homo sapiens
150 PSMD2 5708
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
151 UBE2D1 7321
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
152 ERC2 26059
Affinity Capture-MS Homo sapiens
153 MYH9 4627
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
154 METTL1 4234
Co-fractionation Homo sapiens
155 RNF152 220441
Reconstituted Complex Homo sapiens
156 YOD1  
Biochemical Activity Homo sapiens
157 SMARCC2 6601
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
158 NBPF14 25832
Two-hybrid Homo sapiens
159 YWHAE 7531
Two-hybrid Homo sapiens
160 DDI2 84301
Reconstituted Complex Homo sapiens
161 NEURL4  
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
162 PSMA7 5688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
163 CGGBP1 8545
Two-hybrid Homo sapiens
164 ECH1 1891
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 GMCL1P1  
Affinity Capture-MS Homo sapiens
166 TAT  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
167 HBA1 3039
Two-hybrid Homo sapiens
168 DUSP1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
169 PSMA3 5684
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
170 GOLGA3 2802
Affinity Capture-MS Homo sapiens
171 TRPV5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
172 PAICS 10606
Reconstituted Complex Homo sapiens
173 MYCBP2 23077
Affinity Capture-MS Homo sapiens
174 SPINK1 6690
Reconstituted Complex Homo sapiens
175 IGLC7 28834
Affinity Capture-MS Homo sapiens
176 NDUFA13 51079
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
177 ARPC1B 10095
Co-fractionation Homo sapiens
178 PIP 5304
Affinity Capture-MS Homo sapiens
179 EIF4G1 1981
Two-hybrid Homo sapiens
180 PSMD13 5719
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
181 NELFCD 51497
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
182 JADE1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
183 UBE2L3 7332
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
184 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
185 GTF3C1  
Reconstituted Complex Homo sapiens
186 ANXA1 301
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
187 DLG1 1739
Reconstituted Complex Homo sapiens
188 ASPM 259266
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
189 DOK4 55715
Affinity Capture-MS Homo sapiens
190 PDIA3 2923
Reconstituted Complex Homo sapiens
191 ACTBL2 345651
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
192 NR3C1 2908
Proximity Label-MS Homo sapiens
193 TTC3 7267
Two-hybrid Homo sapiens
194 RPL21 6144
Affinity Capture-MS Homo sapiens
195 PSMA2 5683
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
196 TNPO3 23534
Co-fractionation Homo sapiens
197 PSMB8 5696
Affinity Capture-MS Homo sapiens
198 ZNF250  
Two-hybrid Homo sapiens
199 PHKG2 5261
Affinity Capture-MS Homo sapiens
200 MCM4 4173
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
201 TTC23L  
Two-hybrid Homo sapiens
202 METTL21B  
Affinity Capture-MS Homo sapiens
203 MDM4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
204 PSMD7 5713
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
205 CALM1 801
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
206 KIAA0430  
Two-hybrid Homo sapiens
207 BLK 640
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
208 ECI2 10455
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
209 BPY2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
210 TP53BP2  
Two-hybrid Homo sapiens
211 UBE2D2 7322
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
212 MAPK6  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
213 AHSP  
Two-hybrid Homo sapiens
214 PSMB3 5691
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
215 RPA3 6119
Proximity Label-MS Homo sapiens
216 CEBPZ  
Two-hybrid Homo sapiens
217 PHKB 5257
Affinity Capture-MS Homo sapiens
218 SGK223  
Two-hybrid Homo sapiens
219 SET 6418
Reconstituted Complex Homo sapiens
220 UBE2E1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
221 UFD1L 7353
Co-fractionation Homo sapiens
222 TXNL1 9352
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
223 ARC  
Reconstituted Complex Homo sapiens
224 HSPA1A 3303
Affinity Capture-MS Homo sapiens
225 EEF1A2 1917
Reconstituted Complex Homo sapiens
226 HSPA4 3308
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
227 PSMC5 5705
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
228 PRSS1 5644
Reconstituted Complex Homo sapiens
229 PSMD8 5714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
230 ENO1 2023
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
231 RNF2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
232 SF3B3 23450
Co-fractionation Homo sapiens
233 ALOX12B  
Affinity Capture-MS Homo sapiens
234 MAGEA12  
Two-hybrid Homo sapiens
235 PSMD1 5707
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
236 CDKN1B 1027
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
237 ZNF366  
Affinity Capture-MS Homo sapiens
238 ENTHD2  
Affinity Capture-MS Homo sapiens
239 Psmd6 66413
Affinity Capture-MS Mus musculus
240 PDE1B  
Two-hybrid Homo sapiens
241 MAP7D2 256714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
242 SUMO3 6612
Two-hybrid Homo sapiens
243 UBXN1 51035
Affinity Capture-MS Homo sapiens
244 SOD1 6647
Reconstituted Complex Homo sapiens
245 FAM133A 286499
Affinity Capture-MS Homo sapiens
246 AR 367
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
247 RPH3A 22895
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
248 PSMC3 5702
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
249 SACS 26278
Reconstituted Complex Homo sapiens
250 ZRANB1 54764
Affinity Capture-MS Homo sapiens
251 MAGEA8  
Two-hybrid Homo sapiens
252 PSMB2 5690
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
253 SUGT1 10910
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
254 POLE4  
Two-hybrid Homo sapiens
255 SERHL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
256 MYCBP 26292
Reconstituted Complex Homo sapiens
257 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
258 ESR2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
259 RARA 5914
Two-hybrid Homo sapiens
260 EAPP  
Two-hybrid Homo sapiens
261 PSMB5 5693
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
262 CA10  
Affinity Capture-MS Homo sapiens
263 SHBG 6462
Two-hybrid Homo sapiens
264 KLHL38  
Two-hybrid Homo sapiens
265 TP53 7157
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
266 SNAPC3  
Two-hybrid Homo sapiens
267 FUZ 80199
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
268 XRCC6 2547
Affinity Capture-MS Homo sapiens
269 TALDO1 6888
Reconstituted Complex Homo sapiens
270 ZNF746  
Affinity Capture-MS Homo sapiens
271 SRSF9 8683
Co-fractionation Homo sapiens
272 PSMB7 5695
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
273 OR5M8  
Affinity Capture-MS Homo sapiens
274 MEN1 4221
Affinity Capture-MS Homo sapiens
275 DR1  
Co-fractionation Homo sapiens
276 ZNF446  
Two-hybrid Homo sapiens
277 LCK 3932
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
278 TRIM65 201292
Two-hybrid Homo sapiens
279 PBRM1 55193
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
280 SHFM1 7979
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
281 PTPN2 5771
Affinity Capture-MS Homo sapiens
282 RMI1  
Two-hybrid Homo sapiens
283 KLK7 5650
Affinity Capture-MS Homo sapiens
284 LSM5  
Co-fractionation Homo sapiens
285 PRKACA 5566
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
286 RPS15A 6210
Reconstituted Complex Homo sapiens
287 PSMA1 5682
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
288 UBE3C 9690
Affinity Capture-MS Homo sapiens
289 ESR1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
290 PXMP2  
Proximity Label-MS Homo sapiens
291 UBB 7314
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
292 IL24  
Two-hybrid Homo sapiens
293 ACTA1 58
Affinity Capture-MS Homo sapiens
294 PSMA5 5686
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
295 TANGO6 79613
Affinity Capture-MS Homo sapiens
296 CAD 790
Co-fractionation Homo sapiens
297 DAPK3 1613
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
298 HSF1  
Co-fractionation Homo sapiens
299 ACTA2 59
Reconstituted Complex Homo sapiens
300 ZNF185 7739
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
301 PGK1 5230
Reconstituted Complex Homo sapiens
302 PRDX1 5052
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
303 SERPINB2 5055
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
304 SERBP1 26135
Affinity Capture-MS Homo sapiens
305 EID1  
Two-hybrid Homo sapiens
306 ADRM1 11047
Biochemical Activity Homo sapiens
307 C9orf72  
Affinity Capture-MS Homo sapiens
308 TMEM31  
Affinity Capture-MS Homo sapiens
309 ARNTL2  
Affinity Capture-Western Homo sapiens
310 ANXA2 302
Affinity Capture-MS Homo sapiens
311 CFTR 1080
Co-localization Homo sapiens
312 PSMC4 5704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
313 PLAUR 5329
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
314 PAX6  
Two-hybrid Homo sapiens
315 PRMT1 3276
Affinity Capture-MS Homo sapiens
316 KRT7 3855
Reconstituted Complex Homo sapiens
317 CUL4A 8451
Affinity Capture-MS Homo sapiens
318 MSTO1 55154
Two-hybrid Homo sapiens
319 PSMD3 5709
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
320 PSME4 23198
Affinity Capture-MS Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here