Gene description for PHKA2
Gene name phosphorylase kinase, alpha 2 (liver)
Gene symbol PHKA2
Other names/aliases GSD9A
PHK
PYK
PYKL
XLG
XLG2
Species Homo sapiens
 Database cross references - PHKA2
ExoCarta ExoCarta_5256
Entrez Gene 5256
HGNC 8926
MIM 300798
UniProt P46019  
 PHKA2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PHKA2
Molecular Function
    calmodulin binding GO:0005516 IEA
    phosphorylase kinase activity GO:0004689 IEA
Biological Process
    cellular protein modification process GO:0006464 TAS
    glucose metabolic process GO:0006006 TAS
    glycogen catabolic process GO:0005980 TAS
    protein phosphorylation GO:0006468 IBA
    carbohydrate metabolic process GO:0005975 TAS
    generation of precursor metabolites and energy GO:0006091 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    plasma membrane GO:0005886 IEA
    phosphorylase kinase complex GO:0005964 IEA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified PHKA2 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PHKA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAF1 5894
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PHKA2 is involved
PathwayEvidenceSource
Glycogen breakdown (glycogenolysis) TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here