Gene description for PHKA1
Gene name phosphorylase kinase, alpha 1 (muscle)
Gene symbol PHKA1
Other names/aliases PHKA
Species Homo sapiens
 Database cross references - PHKA1
ExoCarta ExoCarta_5255
Entrez Gene 5255
HGNC 8925
MIM 311870
UniProt P46020  
 PHKA1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PHKA1
Molecular Function
    calmodulin binding GO:0005516 IEA
    phosphorylase kinase activity GO:0004689 TAS
Biological Process
    protein phosphorylation GO:0006468 TAS
    glycogen catabolic process GO:0005980 TAS
    glucose metabolic process GO:0006006 TAS
    carbohydrate metabolic process GO:0005975 TAS
    glycogen metabolic process GO:0005977 TAS
    generation of precursor metabolites and energy GO:0006091 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IEA
    phosphorylase kinase complex GO:0005964 IBA
 Experiment description of studies that identified PHKA1 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PHKA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PHKA1 is involved
PathwayEvidenceSource
Glycogen breakdown (glycogenolysis) TAS Reactome





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