Gene description for PHKG2
Gene name phosphorylase kinase, gamma 2 (testis)
Gene symbol PHKG2
Other names/aliases GSD9C
Species Homo sapiens
 Database cross references - PHKG2
ExoCarta ExoCarta_5261
Vesiclepedia VP_5261
Entrez Gene 5261
HGNC 8931
MIM 172471
UniProt P15735  
 PHKG2 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PHKG2
Molecular Function
    protein serine/threonine kinase activity GO:0004674 TAS
    phosphorylase kinase activity GO:0004689 IBA
    phosphorylase kinase activity GO:0004689 TAS
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IEA
    ATP binding GO:0005524 IEA
    enzyme binding GO:0019899 IEA
    tau-protein kinase activity GO:0050321 TAS
Biological Process
    glycogen metabolic process GO:0005977 IBA
    glycogen catabolic process GO:0005980 IEA
    generation of precursor metabolites and energy GO:0006091 TAS
    protein phosphorylation GO:0006468 TAS
    signal transduction GO:0007165 IBA
    positive regulation of glycogen catabolic process GO:0045819 TAS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    phosphorylase kinase complex GO:0005964 IBA
    phosphorylase kinase complex GO:0005964 TAS
 Experiment description of studies that identified PHKG2 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PHKG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STUB1 10273
Affinity Capture-MS Homo sapiens
2 ATG9B  
Affinity Capture-MS Homo sapiens
3 CALML3 810
Affinity Capture-MS Homo sapiens
4 PRKAA1 5562
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 NPEPPS 9520
Affinity Capture-MS Homo sapiens
6 HPS5 11234
Affinity Capture-MS Homo sapiens
7 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
8 FASN 2194
Affinity Capture-MS Homo sapiens
9 PPP1R3C  
Affinity Capture-MS Homo sapiens
10 PRKAG2 51422
Affinity Capture-MS Homo sapiens
11 GTF3C5 9328
Affinity Capture-MS Homo sapiens
12 TP53 7157
Affinity Capture-MS Homo sapiens
13 SNX1 6642
Affinity Capture-MS Homo sapiens
14 KIF20A 10112
Affinity Capture-MS Homo sapiens
15 TNPO1 3842
Affinity Capture-MS Homo sapiens
16 FAM171B  
Affinity Capture-MS Homo sapiens
17 KIAA1715 80856
Affinity Capture-MS Homo sapiens
18 CALM2 805
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 MAGEA2B  
Two-hybrid Homo sapiens
20 HAUS2  
Affinity Capture-MS Homo sapiens
21 SAP18 10284
Affinity Capture-MS Homo sapiens
22 GAK 2580
Affinity Capture-MS Homo sapiens
23 PHKA2 5256
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 DOK4 55715
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 EML4 27436
Affinity Capture-MS Homo sapiens
26 MAGEA2  
Two-hybrid Homo sapiens
27 UBE3A 7337
Affinity Capture-MS Homo sapiens
28 PEX10  
Affinity Capture-MS Homo sapiens
29 EYA2  
Affinity Capture-MS Homo sapiens
30 ATAD3C 219293
Affinity Capture-MS Homo sapiens
31 MYO19  
Affinity Capture-MS Homo sapiens
32 CDKN1A  
Affinity Capture-MS Homo sapiens
33 PRPF40A 55660
Affinity Capture-MS Homo sapiens
34 NDUFA4 4697
Affinity Capture-MS Homo sapiens
35 ZC3H15 55854
Affinity Capture-MS Homo sapiens
36 CENPV 201161
Affinity Capture-MS Homo sapiens
37 DRG1 4733
Affinity Capture-MS Homo sapiens
38 GCN1L1 10985
Affinity Capture-MS Homo sapiens
39 CALM1 801
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 PHKA1 5255
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 PRKAG1 5571
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ATAD3A 55210
Affinity Capture-MS Homo sapiens
43 VDAC2 7417
Affinity Capture-MS Homo sapiens
44 MPPED1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 LAMC1 3915
Affinity Capture-MS Homo sapiens
46 ACACA 31
Affinity Capture-MS Homo sapiens
47 COMTD1 118881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 CLASP1 23332
Affinity Capture-MS Homo sapiens
49 BZW2 28969
Affinity Capture-MS Homo sapiens
50 CTCFL  
Affinity Capture-MS Homo sapiens
51 YME1L1 10730
Affinity Capture-MS Homo sapiens
52 MYC  
Synthetic Lethality Homo sapiens
53 Ppp1r3b  
Affinity Capture-MS Mus musculus
54 VCP 7415
Affinity Capture-MS Homo sapiens
55 PHKB 5257
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 SCGN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 H3F3C 440093
Affinity Capture-MS Homo sapiens
58 RNF145  
Affinity Capture-MS Homo sapiens
59 CALM3 808
Affinity Capture-MS Homo sapiens
60 PRKDC 5591
Affinity Capture-MS Homo sapiens
61 CEP85L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 RAC1 5879
Affinity Capture-MS Homo sapiens
63 PRKAB2 5565
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 PHKG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 TIAM1  
Affinity Capture-MS Homo sapiens
66 NSUN4  
Affinity Capture-MS Homo sapiens
67 MAPK8 5599
Affinity Capture-MS Homo sapiens
68 PRKAB1 5564
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 FOXK1 221937
Affinity Capture-MS Homo sapiens
70 SETDB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 KIAA0408  
Affinity Capture-MS Homo sapiens
72 TCEANC2  
Affinity Capture-MS Homo sapiens
73 DDX55  
Affinity Capture-MS Homo sapiens
74 HUWE1 10075
Affinity Capture-MS Homo sapiens
75 SCO2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PHKG2 is involved
PathwayEvidenceSource
Glycogen breakdown (glycogenolysis) TAS Reactome
Glycogen metabolism TAS Reactome
Metabolism TAS Reactome
Metabolism of carbohydrates TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here