Gene description for CENPV
Gene name centromere protein V
Gene symbol CENPV
Other names/aliases 3110013H01Rik
CENP-V
PRR6
p30
Species Homo sapiens
 Database cross references - CENPV
ExoCarta ExoCarta_201161
Vesiclepedia VP_201161
Entrez Gene 201161
HGNC 29920
MIM 608139
UniProt Q7Z7K6  
 CENPV identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocytes 26054723    
Thymus 23844026    
 Gene ontology annotations for CENPV
Molecular Function
    protein binding GO:0005515 IPI
    carbon-sulfur lyase activity GO:0016846 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    ameboidal-type cell migration GO:0001667 IDA
    pericentric heterochromatin formation GO:0031508 IBA
    pericentric heterochromatin formation GO:0031508 IMP
    positive regulation of cytokinesis GO:0032467 IBA
    positive regulation of cytokinesis GO:0032467 IMP
    regulation of chromosome organization GO:0033044 IBA
    regulation of chromosome organization GO:0033044 IMP
    centromere complex assembly GO:0034508 IMP
    cell division GO:0051301 IEA
Subcellular Localization
    kinetochore GO:0000776 IBA
    kinetochore GO:0000776 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
    microtubule cytoskeleton GO:0015630 IDA
    midbody GO:0030496 IDA
    nuclear membrane GO:0031965 IDA
    spindle midzone GO:0051233 IBA
    spindle midzone GO:0051233 IDA
 Experiment description of studies that identified CENPV in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CENPV
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLFN11 91607
Affinity Capture-MS Homo sapiens
2 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
3 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
4 NOP56 10528
Affinity Capture-MS Homo sapiens
5 RPL10 6134
Affinity Capture-MS Homo sapiens
6 CHCHD1  
Proximity Label-MS Homo sapiens
7 RPUSD4 84881
Proximity Label-MS Homo sapiens
8 MTRF1  
Proximity Label-MS Homo sapiens
9 ILF2 3608
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 PLEKHO1 51177
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 WDR48 57599
Affinity Capture-MS Homo sapiens
12 TRIM28 10155
Affinity Capture-MS Homo sapiens
13 KIF23 9493
Affinity Capture-MS Homo sapiens
14 PRKY  
Affinity Capture-MS Homo sapiens
15 FBXW7  
Affinity Capture-MS Homo sapiens
16 PRC1 9055
Affinity Capture-MS Homo sapiens
17 CHCHD10  
Affinity Capture-MS Homo sapiens
18 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 ADARB1 104
Affinity Capture-MS Homo sapiens
20 EED  
Affinity Capture-MS Homo sapiens
21 RRP8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 MECP2 4204
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SNX27 81609
Affinity Capture-MS Homo sapiens
24 MYCN  
Affinity Capture-MS Homo sapiens
25 TNFRSF1B  
Affinity Capture-MS Homo sapiens
26 SOD1 6647
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 RBM19 9904
Affinity Capture-MS Homo sapiens
28 CHMP4C 92421
Affinity Capture-MS Homo sapiens
29 S100A2 6273
Affinity Capture-MS Homo sapiens
30 COX15 1355
Affinity Capture-MS Homo sapiens
31 DDX21 9188
Affinity Capture-MS Homo sapiens
32 RPL4 6124
Affinity Capture-MS Homo sapiens
33 LYN 4067
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
34 NOP2 4839
Affinity Capture-MS Homo sapiens
35 TBC1D32 221322
Proximity Label-MS Homo sapiens
36 LGALS13  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 TUBA1B 10376
Affinity Capture-Western Homo sapiens
38 IFI16 3428
Affinity Capture-MS Homo sapiens
39 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
40 RPL37A 6168
Affinity Capture-MS Homo sapiens
41 Bag2  
Affinity Capture-MS Mus musculus
42 CHMP4B 128866
Affinity Capture-MS Homo sapiens
43 HECTD1 25831
Affinity Capture-MS Homo sapiens
44 RPLP0 6175
Affinity Capture-MS Homo sapiens
45 MTRF1L  
Proximity Label-MS Homo sapiens
46 CYLD  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
47 RSL1D1 26156
Affinity Capture-MS Homo sapiens
48 ANLN 54443
Affinity Capture-MS Homo sapiens
49 STK3 6788
Affinity Capture-MS Homo sapiens
50 ECT2 1894
Affinity Capture-MS Homo sapiens
51 RLIM 51132
Affinity Capture-MS Homo sapiens
52 NPM3 10360
Affinity Capture-MS Homo sapiens
53 NR3C1 2908
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
54 DDRGK1 65992
Affinity Capture-MS Homo sapiens
55 PHKG2 5261
Affinity Capture-MS Homo sapiens
56 FNTA 2339
Affinity Capture-MS Homo sapiens
57 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
58 ZC3H10  
Affinity Capture-MS Homo sapiens
59 C12orf65  
Proximity Label-MS Homo sapiens
60 MYC  
Affinity Capture-MS Homo sapiens
61 RPA3 6119
Proximity Label-MS Homo sapiens
62 MAGEB10  
Affinity Capture-MS Homo sapiens
63 DNAJC9 23234
Proximity Label-MS Homo sapiens
64 RPS14 6208
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 PARP1 142
Proximity Label-MS Homo sapiens
66 BMI1  
Affinity Capture-MS Homo sapiens
67 Cbx1  
Affinity Capture-MS Mus musculus
68 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
69 Prkci  
Affinity Capture-MS Mus musculus
70 AUH 549
Proximity Label-MS Homo sapiens
71 KIF14 9928
Affinity Capture-MS Homo sapiens
72 ILF3 3609
Affinity Capture-MS Homo sapiens
73 MRPL11 65003
Proximity Label-MS Homo sapiens
74 DNAJB6 10049
Proximity Label-MS Homo sapiens
75 TUBG1 7283
Affinity Capture-Western Homo sapiens
76 ICT1 3396
Proximity Label-MS Homo sapiens
77 MNDA 4332
Affinity Capture-MS Homo sapiens
78 SSBP1 6742
Proximity Label-MS Homo sapiens
79 EZH2  
Affinity Capture-MS Homo sapiens
80 SORT1 6272
Affinity Capture-MS Homo sapiens
81 LENEP  
Affinity Capture-MS Homo sapiens
82 CIT 11113
Affinity Capture-MS Homo sapiens
83 GRSF1 2926
Proximity Label-MS Homo sapiens
84 C1QBP 708
Proximity Label-MS Homo sapiens
85 HNRNPU 3192
Affinity Capture-MS Homo sapiens
86 CCT8L2  
Affinity Capture-MS Homo sapiens
87 ZNF467  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CENPV is involved
No pathways found





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