Gene description for MNDA
Gene name myeloid cell nuclear differentiation antigen
Gene symbol MNDA
Other names/aliases PYHIN3
Species Homo sapiens
 Database cross references - MNDA
ExoCarta ExoCarta_4332
Entrez Gene 4332
HGNC 7183
MIM 159553
UniProt P41218  
 MNDA identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
Urine 19056867    
 Gene ontology annotations for MNDA
Molecular Function
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IEA
Biological Process
    positive regulation of apoptotic process GO:0043065 IMP
    transcription, DNA-templated GO:0006351 IEA
    B cell receptor signaling pathway GO:0050853 IMP
    cellular defense response GO:0006968 TAS
    negative regulation of B cell proliferation GO:0030889 IMP
    regulation of transcription, DNA-templated GO:0006355 IEA
    cellular response to DNA damage stimulus GO:0006974 IMP
Subcellular Localization
    nucleus GO:0005634 IEA
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified MNDA in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MNDA
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MNDA is involved
No pathways found





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