Gene description for ATXN2L
Gene name ataxin 2-like
Gene symbol ATXN2L
Other names/aliases A2D
A2LG
A2LP
A2RP
Species Homo sapiens
 Database cross references - ATXN2L
ExoCarta ExoCarta_11273
Entrez Gene 11273
HGNC 31326
MIM 607931
UniProt Q8WWM7  
 ATXN2L identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for ATXN2L
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
Biological Process
    stress granule assembly GO:0034063 IMP
    regulation of cytoplasmic mRNA processing body assembly GO:0010603 IDA
Subcellular Localization
    cytoplasmic stress granule GO:0010494 IDA
    membrane GO:0016020 IDA
    cytoplasm GO:0005737 IDA
    nuclear speck GO:0016607 IDA
 Experiment description of studies that identified ATXN2L in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for ATXN2L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MPL 4352
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 EPOR  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which ATXN2L is involved
No pathways found





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