Gene description for FHL2
Gene name four and a half LIM domains 2
Gene symbol FHL2
Other names/aliases AAG11
DRAL
FHL-2
SLIM-3
SLIM3
Species Homo sapiens
 Database cross references - FHL2
ExoCarta ExoCarta_2274
Vesiclepedia VP_2274
Entrez Gene 2274
HGNC 3703
MIM 602633
UniProt Q14192  
 FHL2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
T lymphocytes 34108659    
 Gene ontology annotations for FHL2
Molecular Function
    transcription corepressor activity GO:0003714 IBA
    transcription corepressor activity GO:0003714 ISS
    protein binding GO:0005515 IPI
    transcription factor binding GO:0008134 IPI
    identical protein binding GO:0042802 IPI
    bHLH transcription factor binding GO:0043425 ISS
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    osteoblast differentiation GO:0001649 IEA
    response to hormone GO:0009725 IMP
    negative regulation of apoptotic process GO:0043066 IDA
    atrial cardiac muscle cell development GO:0055014 IEA
    ventricular cardiac muscle cell development GO:0055015 IEA
    heart trabecula formation GO:0060347 IEA
    negative regulation of calcineurin-NFAT signaling cascade GO:0070885 IBA
    negative regulation of calcineurin-NFAT signaling cascade GO:0070885 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
    focal adhesion GO:0005925 HDA
    Z disc GO:0030018 IBA
 Experiment description of studies that identified FHL2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
10
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
15
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
19
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
20
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
21
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
22
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
23
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
24
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
25
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
27
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
28
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
29
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
30
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
31
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for FHL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 REV1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 ITGB1 3688
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 PBX2  
Affinity Capture-MS Homo sapiens
4 WNK1 65125
Affinity Capture-MS Homo sapiens
5 CAND2 23066
Two-hybrid Homo sapiens
6 SH3RF1  
Two-hybrid Homo sapiens
7 BRCA1 672
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
8 GOLGA6A  
Two-hybrid Homo sapiens
9 ZZZ3  
Affinity Capture-MS Homo sapiens
10 UBC 7316
Affinity Capture-MS Homo sapiens
11 PLEKHG2 64857
Affinity Capture-MS Homo sapiens
12 AMOTL1 154810
Affinity Capture-MS Homo sapiens
13 WDR62  
Affinity Capture-MS Homo sapiens
14 MEAF6  
Affinity Capture-MS Homo sapiens
15 MPP5 64398
Affinity Capture-MS Homo sapiens
16 FAM129A 116496
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
17 KPRP 448834
Two-hybrid Homo sapiens
18 HMG20B  
Affinity Capture-MS Homo sapiens
19 PKNOX1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
20 ZFYVE9  
Two-hybrid Homo sapiens
21 SLU7  
Affinity Capture-MS Homo sapiens
22 EEF1A1 1915
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 CKM  
Reconstituted Complex Homo sapiens
24 HEXIM1 10614
Co-fractionation Homo sapiens
25 DLGAP1  
Two-hybrid Homo sapiens
26 TOLLIP 54472
Proximity Label-MS Homo sapiens
27 MTCH2 23788
Affinity Capture-MS Homo sapiens
28 BTG3  
Affinity Capture-MS Homo sapiens
29 CNOT11 55571
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CAPZA1 829
Affinity Capture-MS Homo sapiens
31 IGFBP5 3488
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
32 TRMT61A 115708
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 ZNF76  
Affinity Capture-MS Homo sapiens
34 RFX3 5991
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
35 TTN 7273
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
36 DTX2 113878
Two-hybrid Homo sapiens
37 CNOT6L 246175
Affinity Capture-MS Homo sapiens
38 ITGB2 3689
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
39 NANOS1 340719
Affinity Capture-MS Homo sapiens
40 BIN1 274
Two-hybrid Homo sapiens
41 TRIM63  
Two-hybrid Homo sapiens
42 NRF1 4899
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
43 DSN1 79980
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 ATXN1 6310
Two-hybrid Homo sapiens
45 ASXL2  
Affinity Capture-MS Homo sapiens
46 NFAT5  
Affinity Capture-MS Homo sapiens
47 ANKRD55  
Two-hybrid Homo sapiens
48 CSN2 1447
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
49 TXNRD3  
Two-hybrid Homo sapiens
50 FOXO1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
51 RQCD1 9125
Affinity Capture-MS Homo sapiens
52 TOX3  
Two-hybrid Homo sapiens
53 CUL3 8452
Affinity Capture-MS Homo sapiens
54 SIN3B  
Affinity Capture-MS Homo sapiens
55 NPAS2  
Affinity Capture-MS Homo sapiens
56 ADAMTSL1 92949
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 PHB2 11331
Two-hybrid Homo sapiens
58 SPEN 23013
Affinity Capture-MS Homo sapiens
59 ZNF410  
Two-hybrid Homo sapiens
60 TBL1X 6907
Affinity Capture-MS Homo sapiens
61 SUMO1P1  
Two-hybrid Homo sapiens
62 CDC42EP4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 RAI2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
64 DUSP10 11221
Two-hybrid Homo sapiens
65 SCYL3 57147
Affinity Capture-MS Homo sapiens
66 DEAF1 10522
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
67 EPCAM 4072
Co-fractionation Homo sapiens
68 MAP10  
Affinity Capture-MS Homo sapiens
69 PUF60 22827
Two-hybrid Homo sapiens
70 PSMD3 5709
Co-fractionation Homo sapiens
71 MAGEA9  
Affinity Capture-MS Homo sapiens
72 ATF1  
Affinity Capture-MS Homo sapiens
73 C20orf85  
Two-hybrid Homo sapiens
74 NFIC 4782
Affinity Capture-MS Homo sapiens
75 GATAD1  
Affinity Capture-MS Homo sapiens
76 GABPA 2551
Affinity Capture-MS Homo sapiens
77 DAPL1 92196
Two-hybrid Homo sapiens
78 EPC2  
Affinity Capture-MS Homo sapiens
79 CCAR1 55749
Affinity Capture-MS Homo sapiens
80 ELF1 1997
Affinity Capture-MS Homo sapiens
81 SCNM1  
Two-hybrid Homo sapiens
82 BTF3 689
Affinity Capture-MS Homo sapiens
83 E2F1 1869
Two-hybrid Homo sapiens
84 APC  
Affinity Capture-MS Homo sapiens
85 TNFRSF8 943
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 ZFR 51663
Affinity Capture-MS Homo sapiens
87 ARID3B  
Affinity Capture-MS Homo sapiens
88 SFPQ 6421
Two-hybrid Homo sapiens
89 MBIP  
Affinity Capture-MS Homo sapiens
90 NCOR1  
Affinity Capture-MS Homo sapiens
91 PHC3  
Affinity Capture-MS Homo sapiens
92 BORA  
Affinity Capture-MS Homo sapiens
93 ARID4B  
Affinity Capture-MS Homo sapiens
94 WASH1 100287171
Two-hybrid Homo sapiens
95 E4F1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
96 PHF1  
Two-hybrid Homo sapiens
97 SETD1A 9739
Affinity Capture-MS Homo sapiens
98 ABI1 10006
Two-hybrid Homo sapiens
99 C8orf46  
Two-hybrid Homo sapiens
100 LARP4B 23185
Affinity Capture-MS Homo sapiens
101 FAM154A  
Two-hybrid Homo sapiens
102 RUNX1  
Affinity Capture-Western Homo sapiens
103 PFKM 5213
Reconstituted Complex Homo sapiens
104 FAM154B  
Two-hybrid Homo sapiens
105 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
106 FHL3 2275
Two-hybrid Homo sapiens
FRET Homo sapiens
Two-hybrid Homo sapiens
107 ZBTB16  
Affinity Capture-Western Homo sapiens
Phenotypic Enhancement Homo sapiens
Phenotypic Suppression Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
108 NCOR2  
Affinity Capture-MS Homo sapiens
109 EYA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 ID3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
111 SDF4 51150
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 KLF12  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
113 CYLD  
Affinity Capture-MS Homo sapiens
114 SP2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
115 SAP30L  
Affinity Capture-MS Homo sapiens
116 PKNOX2  
Two-hybrid Homo sapiens
117 CSRP2BP  
Affinity Capture-MS Homo sapiens
118 EGFR 1956
Affinity Capture-Western Homo sapiens
119 ARHGAP9 64333
Two-hybrid Homo sapiens
120 IKZF1  
Two-hybrid Homo sapiens
121 WAPAL  
Affinity Capture-MS Homo sapiens
122 PLEKHA5 54477
Affinity Capture-MS Homo sapiens
123 Cnot3 232791
Affinity Capture-MS Mus musculus
124 TADA2A  
Affinity Capture-MS Homo sapiens
125 BMPR2 659
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
126 MYC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 EP400  
Affinity Capture-MS Homo sapiens
128 RIBC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 BAP1 8314
Affinity Capture-MS Homo sapiens
130 EEF1A2 1917
Affinity Capture-MS Homo sapiens
131 BMI1  
Affinity Capture-MS Homo sapiens
132 RCOR3  
Affinity Capture-MS Homo sapiens
133 FHL2 2274
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
134 FHL1 2273
Reconstituted Complex Homo sapiens
135 PARP1 142
Proximity Label-MS Homo sapiens
136 GMEB2  
Two-hybrid Homo sapiens
137 PTCH1  
Affinity Capture-Western Homo sapiens
138 CAPZA2 830
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 MAGEL2  
Two-hybrid Homo sapiens
140 QSER1  
Affinity Capture-MS Homo sapiens
141 DDIT4L  
Two-hybrid Homo sapiens
142 ESR1  
Two-hybrid Homo sapiens
143 BAG5 9529
Affinity Capture-MS Homo sapiens
144 QRICH1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
145 CNOT8  
Affinity Capture-MS Homo sapiens
146 ALS2CR11  
Two-hybrid Homo sapiens
147 NACC2  
Affinity Capture-MS Homo sapiens
148 GLYR1 84656
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
149 NANOS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
150 PTRF 284119
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
151 AK1 203
Reconstituted Complex Homo sapiens
152 RCOR1  
Affinity Capture-MS Homo sapiens
153 MCM7 4176
Two-hybrid Homo sapiens
154 GATAD2B 57459
Two-hybrid Homo sapiens
155 ALMS1  
Affinity Capture-MS Homo sapiens
156 SP1  
Affinity Capture-MS Homo sapiens
157 REL 5966
Two-hybrid Homo sapiens
158 MORC4  
Affinity Capture-MS Homo sapiens
159 EPB41L5 57669
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
160 GAS8  
Two-hybrid Homo sapiens
161 IL16  
Two-hybrid Homo sapiens
162 CCDC92  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
163 ANKRD17 26057
Affinity Capture-MS Homo sapiens
164 CAPZB 832
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 GNG12 55970
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
166 C11orf30  
Affinity Capture-MS Homo sapiens
167 CNOT10 25904
Affinity Capture-MS Homo sapiens
168 MYBPC1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
169 MCM2 4171
Affinity Capture-MS Homo sapiens
170 ZNF638 27332
Two-hybrid Homo sapiens
FRET Homo sapiens
171 ING3  
Affinity Capture-MS Homo sapiens
172 IQGAP1 8826
Co-fractionation Homo sapiens
173 STAT3 6774
Two-hybrid Homo sapiens
174 LPP 4026
Affinity Capture-MS Homo sapiens
175 USF2 7392
Affinity Capture-MS Homo sapiens
176 YEATS2  
Affinity Capture-MS Homo sapiens
177 YY1AP1 55249
Affinity Capture-MS Homo sapiens
178 GPRC5C 55890
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
179 SIGLEC6  
Two-hybrid Homo sapiens
180 FOXP1 27086
Affinity Capture-MS Homo sapiens
181 TRIM73  
Two-hybrid Homo sapiens
182 KIAA1217 56243
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
183 BANP  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
184 ITGA3 3675
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
185 CNOT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
186 GLIS2  
Affinity Capture-MS Homo sapiens
187 FAM204A  
Two-hybrid Homo sapiens
188 TRIM55  
Two-hybrid Homo sapiens
189 POU6F2  
Two-hybrid Homo sapiens
190 SLAIN1 122060
Two-hybrid Homo sapiens
191 CNOT1 23019
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
192 POGZ 23126
Two-hybrid Homo sapiens
193 DPF2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
194 DCP1A 55802
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
195 ZNF131  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
196 B3GAT2  
Affinity Capture-MS Homo sapiens
197 ZNF655  
Two-hybrid Homo sapiens
198 GTF2H1 2965
Two-hybrid Homo sapiens
199 GTF2F2 2963
Two-hybrid Homo sapiens
200 ATF3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
201 ECH1 1891
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
202 DCTN3 11258
Co-fractionation Homo sapiens
203 CNOT6  
Affinity Capture-MS Homo sapiens
204 FAM60A  
Affinity Capture-MS Homo sapiens
205 DOK4 55715
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
206 TRAF6 7189
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
207 ZSCAN9  
Two-hybrid Homo sapiens
208 SNCAIP  
Affinity Capture-MS Homo sapiens
209 E2F7  
Affinity Capture-MS Homo sapiens
210 SIX5  
Affinity Capture-MS Homo sapiens
211 YY1 7528
Two-hybrid Homo sapiens
212 ODAM  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
213 LDLRAP1 26119
Two-hybrid Homo sapiens
214 LAMTOR5 10542
Affinity Capture-MS Homo sapiens
215 ZNF212  
Two-hybrid Homo sapiens
216 IKZF4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
217 MTUS1  
Affinity Capture-MS Homo sapiens
218 A1CF  
Two-hybrid Homo sapiens
219 RUNX2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
220 C16orf45  
Affinity Capture-MS Homo sapiens
221 ZBTB25  
Two-hybrid Homo sapiens
222 PABPN1L  
Affinity Capture-MS Homo sapiens
223 AMOT 154796
Two-hybrid Homo sapiens
224 KIAA1671  
Affinity Capture-MS Homo sapiens
225 HIPK1 204851
Affinity Capture-MS Homo sapiens
226 FOXK1 221937
Affinity Capture-MS Homo sapiens
227 ZNF417  
Two-hybrid Homo sapiens
228 HIF1A 3091
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
229 APP 351
Reconstituted Complex Homo sapiens
230 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
231 DCDC2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
232 JUP 3728
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
233 SIN3A  
Affinity Capture-MS Homo sapiens
234 MKL2  
Affinity Capture-MS Homo sapiens
235 BLZF1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
236 RIPPLY1  
Two-hybrid Homo sapiens
237 PRRC2C 23215
Affinity Capture-MS Homo sapiens
238 INCA1  
Two-hybrid Homo sapiens
239 CREBBP  
Affinity Capture-Western Homo sapiens
240 MTHFD1 4522
Affinity Capture-MS Homo sapiens
241 RAVER1 125950
Affinity Capture-MS Homo sapiens
242 SP4  
Affinity Capture-MS Homo sapiens
243 MBNL1 4154
Affinity Capture-MS Homo sapiens
244 TRIM37  
Proximity Label-MS Homo sapiens
245 KANK2 25959
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
246 AR 367
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
247 ZNF331  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
248 EP300 2033
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
249 SP3  
Affinity Capture-MS Homo sapiens
250 CNOT7 29883
Affinity Capture-MS Homo sapiens
251 VTI1B 10490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
252 CSK 1445
Two-hybrid Homo sapiens
253 MKL1 57591
Affinity Capture-MS Homo sapiens
254 ATXN2L 11273
Affinity Capture-MS Homo sapiens
255 GNG4  
Two-hybrid Homo sapiens
256 TNRC18  
Affinity Capture-MS Homo sapiens
257 MYO15B 80022
Two-hybrid Homo sapiens
258 NFYC 4802
Affinity Capture-MS Homo sapiens
259 SAP30 8819
Affinity Capture-MS Homo sapiens
260 MILR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
261 PBX3  
Affinity Capture-MS Homo sapiens
262 PSEN2 5664
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
263 ZNF3  
Two-hybrid Homo sapiens
264 E2F2 1870
Two-hybrid Homo sapiens
265 ITGA7 3679
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
266 CDC42SE1  
Affinity Capture-MS Homo sapiens
267 ZNF408  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
268 DYRK1A 1859
Affinity Capture-MS Homo sapiens
269 TGFB1 7040
Affinity Capture-MS Homo sapiens
270 TBL1XR1 79718
Affinity Capture-MS Homo sapiens
271 RASL12 51285
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
272 KIF5B 3799
Two-hybrid Homo sapiens
273 CASC5  
Affinity Capture-MS Homo sapiens
274 CPLX3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
275 AMER1  
Affinity Capture-MS Homo sapiens
276 ALX4  
Affinity Capture-MS Homo sapiens
277 ASH2L 9070
Affinity Capture-MS Homo sapiens
278 INADL 10207
Affinity Capture-MS Homo sapiens
279 MYCN  
Affinity Capture-MS Homo sapiens
280 AKIP1  
Two-hybrid Homo sapiens
281 MAPK1 5594
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
282 E2F4  
Two-hybrid Homo sapiens
283 TCP10L  
Two-hybrid Homo sapiens
284 RFX1  
Affinity Capture-MS Homo sapiens
285 FANCD2OS  
Affinity Capture-MS Homo sapiens
286 HCK 3055
Two-hybrid Homo sapiens
287 BRMS1 25855
Affinity Capture-MS Homo sapiens
288 TNKS1BP1 85456
Affinity Capture-MS Homo sapiens
289 LRIF1  
Two-hybrid Homo sapiens
290 ZNF85  
Two-hybrid Homo sapiens
291 SREBF2 6721
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
292 SPRY4 81848
Two-hybrid Homo sapiens
293 ZNF23  
Two-hybrid Homo sapiens
294 FOXK2  
Affinity Capture-MS Homo sapiens
295 SRF  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
296 BMP2K 55589
Affinity Capture-MS Homo sapiens
297 PML 5371
Affinity Capture-MS Homo sapiens
298 SUDS3  
Affinity Capture-MS Homo sapiens
299 ARID4A  
Affinity Capture-MS Homo sapiens
300 ING2  
Affinity Capture-MS Homo sapiens
301 ZMYM4  
Two-hybrid Homo sapiens
302 RBM5  
Affinity Capture-MS Homo sapiens
303 MITF  
Affinity Capture-MS Homo sapiens
304 RNF111 54778
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
305 CTNNB1 1499
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
306 ZNF143  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
307 SAP30BP  
Two-hybrid Homo sapiens
308 RBMS1 5937
Affinity Capture-MS Homo sapiens
309 IER3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
310 RBM27  
Affinity Capture-MS Homo sapiens
311 BBX 56987
Affinity Capture-MS Homo sapiens
312 BRMS1L  
Affinity Capture-MS Homo sapiens
313 ERP44 23071
Co-fractionation Homo sapiens
314 NBPF6  
Two-hybrid Homo sapiens
315 RGPD5  
Affinity Capture-MS Homo sapiens
316 PHF21A  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
317 KAT5  
Affinity Capture-MS Homo sapiens
318 MYT1  
Affinity Capture-MS Homo sapiens
319 BAHCC1  
Affinity Capture-MS Homo sapiens
320 PPP1R32  
Two-hybrid Homo sapiens
321 TOB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
322 ZNF626  
Two-hybrid Homo sapiens
323 MDM2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
324 HSPB2  
Two-hybrid Homo sapiens
325 SNAI1  
Two-hybrid Homo sapiens
326 SAP130  
Affinity Capture-MS Homo sapiens
327 NUFIP2 57532
Affinity Capture-MS Homo sapiens
328 ZFP64  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
329 TRAT1 50852
Affinity Capture-MS Homo sapiens
330 PDHB 5162
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
331 ITGB6 3694
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
332 CNOT3 4849
Affinity Capture-MS Homo sapiens
333 CREB1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
334 PRR5L  
Two-hybrid Homo sapiens
335 E2F3  
Two-hybrid Homo sapiens
336 ZNF620  
Two-hybrid Homo sapiens
337 ING1  
Affinity Capture-MS Homo sapiens
338 WNK3  
Affinity Capture-MS Homo sapiens
339 ZNF106  
Affinity Capture-MS Homo sapiens
340 Cnot2  
Affinity Capture-MS Mus musculus
341 HIPK2 28996
Affinity Capture-MS Homo sapiens
342 MBD3L1  
Two-hybrid Homo sapiens
343 USF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
344 HSF2BP  
Two-hybrid Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here