Gene description for TBL1XR1
Gene name transducin (beta)-like 1 X-linked receptor 1
Gene symbol TBL1XR1
Other names/aliases C21
DC42
IRA1
TBLR1
Species Homo sapiens
 Database cross references - TBL1XR1
ExoCarta ExoCarta_79718
Entrez Gene 79718
HGNC 29529
MIM 608628
UniProt Q9BZK7  
 TBL1XR1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for TBL1XR1
Molecular Function
    protein binding GO:0005515 IPI
    histone binding GO:0042393 IDA
    beta-catenin binding GO:0008013 IPI
    transcription regulatory region DNA binding GO:0044212 ISS
    transcription corepressor activity GO:0003714 IGI
    protein N-terminus binding GO:0047485 IPI
Biological Process
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    histone deacetylation GO:0016575 IBA
    cellular lipid metabolic process GO:0044255 TAS
    small molecule metabolic process GO:0044281 TAS
    transcription, DNA-templated GO:0006351 IEA
    canonical Wnt signaling pathway GO:0060070 IMP
    chromatin organization GO:0006325 TAS
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS
    Notch signaling pathway GO:0007219 TAS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    nucleus GO:0005634 IDA
    spindle microtubule GO:0005876 IDA
    transcriptional repressor complex GO:0017053 IDA
    histone deacetylase complex GO:0000118 IDA
 Experiment description of studies that identified TBL1XR1 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TBL1XR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIST2H2BE 8349
Reconstituted Complex Homo sapiens
2 HDAC3 8841
Affinity Capture-MS Homo sapiens
3 NCOR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
4 HIST2H4A 8370
Reconstituted Complex Homo sapiens
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