Gene description for TGM1
Gene name transglutaminase 1
Gene symbol TGM1
Other names/aliases ARCI1
ICR2
KTG
LI
LI1
TGASE
TGK
Species Homo sapiens
 Database cross references - TGM1
ExoCarta ExoCarta_7051
Entrez Gene 7051
HGNC 11777
MIM 190195
UniProt P22735  
 TGM1 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for TGM1
Molecular Function
    protein binding GO:0005515 IPI
    protein-glutamine gamma-glutamyltransferase activity GO:0003810 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    keratinization GO:0031424 IEA
    keratinocyte differentiation GO:0030216 IDA
    cell envelope organization GO:0043163 TAS
    organ morphogenesis GO:0009887 IEA
    peptide cross-linking GO:0018149 IEA
    cellular protein modification process GO:0006464 NAS
Subcellular Localization
    cornified envelope GO:0001533 TAS
    extracellular exosome GO:0070062 IDA
    cell-cell adherens junction GO:0005913 IEA
    intrinsic component of membrane GO:0031224 IDA
 Experiment description of studies that identified TGM1 in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for TGM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEMG1 6406
Invitro Homo sapiens
2 SEMG2 6407
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which TGM1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here