Gene description for CSGALNACT1
Gene name chondroitin sulfate N-acetylgalactosaminyltransferase 1
Gene symbol CSGALNACT1
Other names/aliases CSGalNAcT-1
ChGn
beta4GalNAcT
Species Homo sapiens
 Database cross references - CSGALNACT1
ExoCarta ExoCarta_55790
Vesiclepedia VP_55790
Entrez Gene 55790
HGNC 24290
UniProt Q8TDX6  
 CSGALNACT1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CSGALNACT1
Molecular Function
    protein binding GO:0005515 IPI
    acetylgalactosaminyltransferase activity GO:0008376 IDA
    acetylgalactosaminyltransferase activity GO:0008376 ISS
    peptidoglycan glycosyltransferase activity GO:0008955 IDA
    glucuronosyltransferase activity GO:0015020 IDA
    metal ion binding GO:0046872 NAS
    glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity GO:0047237 IDA
    glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity GO:0047238 IBA
    glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity GO:0047238 IDA
    glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity GO:0047238 TAS
Biological Process
    endochondral ossification GO:0001958 IEA
    heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 NAS
    UDP-N-acetylgalactosamine metabolic process GO:0019276 IDA
    proteoglycan biosynthetic process GO:0030166 ISS
    extracellular matrix organization GO:0030198 IEA
    chondroitin sulfate biosynthetic process GO:0030206 IBA
    chondroitin sulfate biosynthetic process GO:0030206 IDA
    chondroitin sulfate biosynthetic process GO:0030206 TAS
    heparin biosynthetic process GO:0030210 NAS
    UDP-glucuronate metabolic process GO:0046398 IDA
    chondroitin sulfate proteoglycan biosynthetic process GO:0050650 ISS
    dermatan sulfate proteoglycan biosynthetic process GO:0050651 ISS
    chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0050653 IDA
    cartilage development GO:0051216 IEA
Subcellular Localization
    Golgi membrane GO:0000139 NAS
    Golgi membrane GO:0000139 TAS
    Golgi cisterna membrane GO:0032580 IEA
 Experiment description of studies that identified CSGALNACT1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CSGALNACT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATP2B3 492
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 BRD8 10902
Affinity Capture-MS Homo sapiens
3 YEATS4  
Affinity Capture-MS Homo sapiens
4 LRRC15 131578
Affinity Capture-MS Homo sapiens
5 ARFGEF2 10564
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 CSGALNACT2 55454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 LYG2  
Affinity Capture-MS Homo sapiens
8 FAM26D  
Affinity Capture-MS Homo sapiens
9 IVL 3713
Affinity Capture-MS Homo sapiens
10 DSG3 1830
Affinity Capture-MS Homo sapiens
11 CALML3 810
Affinity Capture-MS Homo sapiens
12 CTSV 1515
Affinity Capture-MS Homo sapiens
13 HEPHL1  
Affinity Capture-MS Homo sapiens
14 TMEM214 54867
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 DSC3 1825
Affinity Capture-MS Homo sapiens
16 SLC30A1 7779
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CRYAB 1410
Affinity Capture-MS Homo sapiens
18 ARFGEF1 10565
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 TMUB1  
Affinity Capture-MS Homo sapiens
20 POF1B 79983
Affinity Capture-MS Homo sapiens
21 ACTR6  
Affinity Capture-MS Homo sapiens
22 VSIG8  
Affinity Capture-MS Homo sapiens
23 S100A3  
Affinity Capture-MS Homo sapiens
24 EPC1  
Affinity Capture-MS Homo sapiens
25 EP400  
Affinity Capture-MS Homo sapiens
26 LPCAT3 10162
Affinity Capture-MS Homo sapiens
27 PKP1 5317
Affinity Capture-MS Homo sapiens
28 KIAA1467 57613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 ACIN1 22985
Co-fractionation Homo sapiens
30 DUSP14 11072
Affinity Capture-MS Homo sapiens
31 DMAP1 55929
Affinity Capture-MS Homo sapiens
32 HIST1H1B 3009
Affinity Capture-MS Homo sapiens
33 SRCAP  
Affinity Capture-MS Homo sapiens
34 PADI3 51702
Affinity Capture-MS Homo sapiens
35 TGM3 7053
Affinity Capture-MS Homo sapiens
36 VPS72  
Affinity Capture-MS Homo sapiens
37 SELENBP1 8991
Affinity Capture-MS Homo sapiens
38 SPINK5 11005
Affinity Capture-MS Homo sapiens
39 FBP1 2203
Affinity Capture-MS Homo sapiens
40 DSG4 147409
Affinity Capture-MS Homo sapiens
41 LGALS7B 653499
Affinity Capture-MS Homo sapiens
42 PPP2CA 5515
Affinity Capture-MS Homo sapiens
43 PLCD1 5333
Affinity Capture-MS Homo sapiens
44 TRRAP 8295
Affinity Capture-MS Homo sapiens
45 AIM1 202
Affinity Capture-MS Homo sapiens
46 NEU2  
Affinity Capture-MS Homo sapiens
47 DSC2 1824
Affinity Capture-MS Homo sapiens
48 TMX4 56255
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 PLP2 5355
Affinity Capture-MS Homo sapiens
50 CST6  
Affinity Capture-MS Homo sapiens
51 LCN2 3934
Affinity Capture-MS Homo sapiens
52 GPRC5B 51704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 DNMT1 1786
Affinity Capture-MS Homo sapiens
54 PPP2R2D 55844
Affinity Capture-MS Homo sapiens
55 TIMELESS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 SERPINB13 5275
Affinity Capture-MS Homo sapiens
57 STX6 10228
Co-fractionation Homo sapiens
58 TGM1 7051
Affinity Capture-MS Homo sapiens
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