Gene description for ACIN1
Gene name apoptotic chromatin condensation inducer 1
Gene symbol ACIN1
Other names/aliases ACINUS
ACN
fSAP152
Species Homo sapiens
 Database cross references - ACIN1
ExoCarta ExoCarta_22985
Entrez Gene 22985
HGNC 17066
MIM 604562
UniProt Q9UKV3  
 ACIN1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ACIN1
Molecular Function
    nucleotide binding GO:0000166 IEA
    poly(A) RNA binding GO:0044822 IDA
    nucleic acid binding GO:0003676 NAS
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 NAS
    ATPase activity GO:0016887 NAS
Biological Process
    RNA splicing GO:0008380 IEA
    positive regulation of apoptotic process GO:0043065 IDA
    programmed cell death GO:0012501 TAS
    negative regulation of mRNA splicing, via spliceosome GO:0048025 IDA
    cellular component disassembly involved in execution phase of apoptosis GO:0006921 TAS
    positive regulation of defense response to virus by host GO:0002230 IMP
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP
    positive regulation of monocyte differentiation GO:0045657 IEP
    apoptotic process GO:0006915 TAS
    mRNA processing GO:0006397 IEA
    apoptotic chromosome condensation GO:0030263 IDA
    erythrocyte differentiation GO:0030218 IEP
Subcellular Localization
    nucleolus GO:0005730 IEA
    plasma membrane GO:0005886 IDA
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IDA
    nuclear speck GO:0016607 IDA
    ASAP complex GO:0061574 IDA
    exon-exon junction complex GO:0035145 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified ACIN1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ACIN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PAFAH1B2 5049
Two-hybrid Homo sapiens
2 ABCF3 55324
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ACIN1 is involved
PathwayEvidenceSource
Apoptotic cleavage of cellular proteins TAS Reactome





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