Gene description for ATP7A
Gene name ATPase, Cu++ transporting, alpha polypeptide
Gene symbol ATP7A
Other names/aliases DSMAX
MK
MNK
SMAX3
Species Homo sapiens
 Database cross references - ATP7A
ExoCarta ExoCarta_538
Vesiclepedia VP_538
Entrez Gene 538
HGNC 869
MIM 300011
UniProt Q04656  
 ATP7A identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for ATP7A
Molecular Function
    copper ion transmembrane transporter activity GO:0005375 ISS
    copper ion binding GO:0005507 IBA
    copper ion binding GO:0005507 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    ATP binding GO:0005524 TAS
    superoxide dismutase copper chaperone activity GO:0016532 ISS
    ATP hydrolysis activity GO:0016887 IEA
    small GTPase binding GO:0031267 IEA
    copper-dependent protein binding GO:0032767 IDA
    copper-dependent protein binding GO:0032767 IPI
    P-type divalent copper transporter activity GO:0043682 IBA
    P-type divalent copper transporter activity GO:0043682 ISS
    protein-folding chaperone binding GO:0051087 IEA
    P-type monovalent copper transporter activity GO:0140581 IDA
    cuprous ion binding GO:1903136 IDA
    cuprous ion binding GO:1903136 IMP
Biological Process
    blood vessel development GO:0001568 ISS
    in utero embryonic development GO:0001701 IEA
    liver development GO:0001889 IEA
    blood vessel remodeling GO:0001974 ISS
    regulation of oxidative phosphorylation GO:0002082 ISS
    tryptophan metabolic process GO:0006568 ISS
    catecholamine metabolic process GO:0006584 ISS
    copper ion transport GO:0006825 IMP
    intracellular copper ion homeostasis GO:0006878 IBA
    intracellular copper ion homeostasis GO:0006878 IMP
    mitochondrion organization GO:0007005 ISS
    female pregnancy GO:0007565 IEA
    lactation GO:0007595 IEA
    locomotory behavior GO:0007626 ISS
    response to iron(III) ion GO:0010041 IEA
    response to manganese ion GO:0010042 IEA
    response to zinc ion GO:0010043 IEA
    detoxification of copper ion GO:0010273 ISS
    positive regulation of lamellipodium assembly GO:0010592 IEA
    copper ion import GO:0015677 IBA
    copper ion import GO:0015677 ISS
    peptidyl-lysine modification GO:0018205 ISS
    removal of superoxide radicals GO:0019430 ISS
    cerebellar Purkinje cell differentiation GO:0021702 ISS
    pyramidal neuron development GO:0021860 ISS
    central nervous system neuron development GO:0021954 ISS
    extracellular matrix organization GO:0030198 ISS
    collagen fibril organization GO:0030199 ISS
    hair follicle morphogenesis GO:0031069 ISS
    positive regulation of tyrosinase activity GO:0032773 IMP
    negative regulation of iron ion transmembrane transport GO:0034760 IEA
    cellular response to platelet-derived growth factor stimulus GO:0036120 IEA
    T-helper cell differentiation GO:0042093 ISS
    epinephrine metabolic process GO:0042414 ISS
    norepinephrine metabolic process GO:0042415 ISS
    dopamine metabolic process GO:0042417 ISS
    serotonin metabolic process GO:0042428 ISS
    positive regulation of catalytic activity GO:0043085 ISS
    pigmentation GO:0043473 ISS
    skin development GO:0043588 ISS
    positive regulation of cell size GO:0045793 IEA
    positive regulation of melanin biosynthetic process GO:0048023 IMP
    elastic fiber assembly GO:0048251 ISS
    lung alveolus development GO:0048286 ISS
    neuron projection morphogenesis GO:0048812 ISS
    positive regulation of epithelial cell proliferation GO:0050679 IEA
    cartilage development GO:0051216 ISS
    elastin biosynthetic process GO:0051542 ISS
    copper ion export GO:0060003 IBA
    copper ion export GO:0060003 IDA
    copper ion export GO:0060003 ISS
    cellular response to amino acid stimulus GO:0071230 IEA
    cellular response to antibiotic GO:0071236 IEA
    cellular response to cadmium ion GO:0071276 IEA
    cellular response to cobalt ion GO:0071279 IEA
    cellular response to copper ion GO:0071280 IEA
    cellular response to iron ion GO:0071281 IEA
    cellular response to lead ion GO:0071284 IEA
    cellular response to hypoxia GO:0071456 IEA
    positive regulation of response to wounding GO:1903036 IEA
    positive regulation of vascular associated smooth muscle cell migration GO:1904754 IEA
Subcellular Localization
    late endosome GO:0005770 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum GO:0005783 IEA
    Golgi apparatus GO:0005794 IDA
    trans-Golgi network GO:0005802 IBA
    trans-Golgi network GO:0005802 IDA
    cytosol GO:0005829 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    microvillus GO:0005902 IEA
    postsynaptic density GO:0014069 IEA
    membrane GO:0016020 HDA
    basolateral plasma membrane GO:0016323 IDA
    apical plasma membrane GO:0016324 IEA
    trans-Golgi network transport vesicle GO:0030140 IMP
    secretory granule GO:0030141 IEA
    axon GO:0030424 ISS
    dendrite GO:0030425 ISS
    phagocytic vesicle membrane GO:0030670 TAS
    cell leading edge GO:0031252 IEA
    brush border membrane GO:0031526 IEA
    early endosome membrane GO:0031901 ISS
    trans-Golgi network membrane GO:0032588 ISS
    melanosome membrane GO:0033162 ISS
    neuron projection GO:0043005 ISS
    neuronal cell body GO:0043025 ISS
    perikaryon GO:0043204 IEA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified ATP7A in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ATP7A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TACR3  
Affinity Capture-MS Homo sapiens
2 FOXF2  
Affinity Capture-MS Homo sapiens
3 MCAM 4162
Proximity Label-MS Homo sapiens
4 GJD3  
Proximity Label-MS Homo sapiens
5 LGALS9 3965
Affinity Capture-MS Homo sapiens
6 SNX27 81609
Affinity Capture-Western Homo sapiens
7 PCDHGB1  
Affinity Capture-MS Homo sapiens
8 TMEM132D  
Two-hybrid Homo sapiens
9 RAB35 11021
Proximity Label-MS Homo sapiens
10 WHAMMP3  
Affinity Capture-MS Homo sapiens
11 Anapc13  
Affinity Capture-MS Mus musculus
12 CD3D 915
Affinity Capture-MS Homo sapiens
13 TMEM59 9528
Affinity Capture-MS Homo sapiens
14 OCLN 100506658
Proximity Label-MS Homo sapiens
15 FURIN 5045
Affinity Capture-MS Homo sapiens
16 POLR2J  
Affinity Capture-MS Homo sapiens
17 LAMTOR1 55004
Proximity Label-MS Homo sapiens
18 LAMP3  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
19 SLC9A3R2 9351
Affinity Capture-MS Homo sapiens
20 C3AR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CD83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 HCST  
Affinity Capture-MS Homo sapiens
23 CX3CL1  
Affinity Capture-MS Homo sapiens
24 PSCA 8000
Affinity Capture-MS Homo sapiens
25 LAMP1 3916
Proximity Label-MS Homo sapiens
26 CLEC2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 DNAJB2 3300
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 IGHM 3507
Affinity Capture-MS Homo sapiens
29 MGARP  
Affinity Capture-MS Homo sapiens
30 RAB29 8934
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 GJA1 2697
Proximity Label-MS Homo sapiens
32 ATG9A 79065
Proximity Label-MS Homo sapiens
33 LAMP2 3920
Proximity Label-MS Homo sapiens
34 TMEM130  
Affinity Capture-MS Homo sapiens
35 KLRD1  
Affinity Capture-MS Homo sapiens
36 TSPAN16  
Affinity Capture-MS Homo sapiens
37 IFT27 11020
Affinity Capture-MS Homo sapiens
38 CLU 1191
Affinity Capture-Western Homo sapiens
39 GLRX 2745
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
40 LY6G5C  
Affinity Capture-MS Homo sapiens
41 ITM2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 LYN 4067
Proximity Label-MS Homo sapiens
43 DNAJC5 80331
Proximity Label-MS Homo sapiens
44 ACIN1 22985
Co-fractionation Homo sapiens
45 RAB4A 5867
Proximity Label-MS Homo sapiens
46 RPS27 6232
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 COG6 57511
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 RAB2A 5862
Proximity Label-MS Homo sapiens
49 LAGE3  
Affinity Capture-MS Homo sapiens
50 C11orf87  
Affinity Capture-MS Homo sapiens
51 DIRAS3  
Proximity Label-MS Homo sapiens
52 OR10H1  
Affinity Capture-MS Homo sapiens
53 NTRK1 4914
Affinity Capture-MS Homo sapiens
54 RAB7A 7879
Proximity Label-MS Homo sapiens
55 APBB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 NCR3LG1 374383
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 ORAI1 84876
Affinity Capture-MS Homo sapiens
58 PLK1 5347
Affinity Capture-MS Homo sapiens
59 EPHA2 1969
Proximity Label-MS Homo sapiens
60 NUBP1 4682
Affinity Capture-MS Homo sapiens
61 STX7 8417
Proximity Label-MS Homo sapiens
62 KRAS 3845
Proximity Label-MS Homo sapiens
63 RAB5C 5878
Proximity Label-MS Homo sapiens
64 RHOB 388
Proximity Label-MS Homo sapiens
65 CHODL 140578
Affinity Capture-MS Homo sapiens
66 C11orf52 91894
Proximity Label-MS Homo sapiens
67 SEMA4C 54910
Affinity Capture-MS Homo sapiens
68 COG5 10466
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 KLK12  
Affinity Capture-MS Homo sapiens
70 ATOX1 475
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
71 COMMD1 150684
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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