Gene description for ATP7A
Gene name	ATPase, Cu++ transporting, alpha polypeptide
Gene symbol	ATP7A
Other names/aliases	DSMAX MK MNK SMAX3
Species	Homo sapiens
Database cross references - ATP7A
ExoCarta	ExoCarta_538
Entrez Gene	538
HGNC	869
MIM	300011
UniProt	Q04656
ATP7A identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Platelets	25332113
Platelets	25332113
Platelets	25332113
Urine	21595033
Urine	21595033
Urine	21595033

Gene ontology annotations for ATP7A

Molecular Function     copper-dependent protein binding GO:0032767 IPI     protein binding GO:0005515 IPI     copper-exporting ATPase activity GO:0004008 ISS     copper ion transmembrane transporter activity GO:0005375 ISS     ATP binding GO:0005524 TAS     copper ion binding GO:0005507 IDA     superoxide dismutase copper chaperone activity GO:0016532 ISS Biological Process     release of cytochrome c from mitochondria GO:0001836 IEA     epinephrine metabolic process GO:0042414 ISS     extracellular matrix organization GO:0030198 ISS     dopamine metabolic process GO:0042417 ISS     removal of superoxide radicals GO:0019430 ISS     response to iron(III) ion GO:0010041 IEA     hair follicle morphogenesis GO:0031069 ISS     copper ion transport GO:0006825 IMP     locomotory behavior GO:0007626 ISS     blood vessel development GO:0001568 ISS     pyramidal neuron development GO:0021860 ISS     response to zinc ion GO:0010043 IEA     regulation of oxidative phosphorylation GO:0002082 ISS     regulation of gene expression GO:0010468 IEA     detoxification of copper ion GO:0010273 ISS     cartilage development GO:0051216 ISS     norepinephrine metabolic process GO:0042415 ISS     cellular copper ion homeostasis GO:0006878 IMP     ATP metabolic process GO:0046034 IEA     skin development GO:0043588 ISS     neuron projection morphogenesis GO:0048812 ISS     norepinephrine biosynthetic process GO:0042421 IEA     in utero embryonic development GO:0001701 IEA     copper ion export GO:0060003 ISS     response to reactive oxygen species GO:0000302 TAS     cerebellar Purkinje cell differentiation GO:0021702 ISS     lactation GO:0007595 IEA     catecholamine metabolic process GO:0006584 ISS     copper ion import GO:0015677 ISS     mitochondrion organization GO:0007005 ISS     ion transmembrane transport GO:0034220 TAS     tyrosine metabolic process GO:0006570 IEA     pigmentation GO:0043473 ISS     positive regulation of oxidoreductase activity GO:0051353 IDA     blood vessel remodeling GO:0001974 ISS     positive regulation of metalloenzyme activity GO:0048554 ISS     plasma membrane copper ion transport GO:0015679 IEA     elastic fiber assembly GO:0048251 ISS     central nervous system neuron development GO:0021954 ISS     lung alveolus development GO:0048286 ISS     collagen fibril organization GO:0030199 ISS     positive regulation of catalytic activity GO:0043085 ISS     serotonin metabolic process GO:0042428 ISS     tryptophan metabolic process GO:0006568 ISS     T-helper cell differentiation GO:0042093 ISS     negative regulation of metalloenzyme activity GO:0048553 ISS     negative regulation of neuron apoptotic process GO:0043524 IEA     elastin biosynthetic process GO:0051542 ISS     dendrite morphogenesis GO:0048813 IEA     transmembrane transport GO:0055085 TAS     peptidyl-lysine modification GO:0018205 ISS Subcellular Localization     brush border membrane GO:0031526 IEA     basolateral plasma membrane GO:0016323 IDA     neuronal cell body GO:0043025 ISS     neuron projection GO:0043005 ISS     endoplasmic reticulum GO:0005783 IEA     Golgi apparatus GO:0005794 IDA     integral component of membrane GO:0016021 IEA     late endosome GO:0005770 IDA     secretory granule GO:0030141 IEA     trans-Golgi network transport vesicle GO:0030140 IMP     perinuclear region of cytoplasm GO:0048471 IDA     membrane GO:0016020 IDA     cytosol GO:0005829 IEA     plasma membrane GO:0005886 TAS     trans-Golgi network GO:0005802 IDA