Gene description for NCR3LG1
Gene name natural killer cell cytotoxicity receptor 3 ligand 1
Gene symbol NCR3LG1
Other names/aliases B7-H6
B7H6
DKFZp686O24166
Species Homo sapiens
 Database cross references - NCR3LG1
ExoCarta ExoCarta_374383
Vesiclepedia VP_374383
Entrez Gene 374383
HGNC 42400
MIM 613714
UniProt Q68D85  
 NCR3LG1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 34887515    
 Gene ontology annotations for NCR3LG1
Molecular Function
    protein binding GO:0005515 IPI
    receptor ligand activity GO:0048018 IDA
Biological Process
    signal transduction GO:0007165 IEA
    NK T cell activation GO:0051132 IDA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified NCR3LG1 in exosomes
1
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
 Protein-protein interactions for NCR3LG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TMEM189-UBE2V1 387522
Affinity Capture-MS Homo sapiens
2 UPK2 7379
Affinity Capture-MS Homo sapiens
3 PIGG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 TMEM14C 51522
Two-hybrid Homo sapiens
5 RAET1E  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 MYADM 91663
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 LGALS9 3965
Affinity Capture-MS Homo sapiens
8 ARL2 402
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 CD200R1 131450
Affinity Capture-MS Homo sapiens
10 FAM73A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 C14orf180  
Two-hybrid Homo sapiens
12 SEC14L1 6397
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 GRK6 2870
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ABCB8 11194
Affinity Capture-MS Homo sapiens
15 PSMB3 5691
Affinity Capture-MS Homo sapiens
16 C14orf1 11161
Two-hybrid Homo sapiens
17 FAM171A2 284069
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 MICA 100507436
Affinity Capture-MS Homo sapiens
19 TNF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 SCPEP1 59342
Affinity Capture-MS Homo sapiens
21 EIF1AX 1964
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 IL20RB  
Affinity Capture-MS Homo sapiens
23 DSTYK 25778
Affinity Capture-MS Homo sapiens
24 PTH2R  
Affinity Capture-MS Homo sapiens
25 RYK 6259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 DNAAF5 54919
Affinity Capture-MS Homo sapiens
27 GGPS1  
Affinity Capture-MS Homo sapiens
28 CEACAM21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 OMA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 FAM63B 54629
Affinity Capture-MS Homo sapiens
31 IL3RA  
Affinity Capture-MS Homo sapiens
32 TBCD 6904
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 PDCD1LG2 80380
Affinity Capture-MS Homo sapiens
34 XPO6 23214
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 DEGS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 TNPO2 30000
Affinity Capture-MS Homo sapiens
37 ZER1 10444
Affinity Capture-MS Homo sapiens
38 XPO5 57510
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 DAGLB 221955
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 ATR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 HLA-DPA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 SNX17 9784
Affinity Capture-MS Homo sapiens
43 TOMM40 10452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 COL4A5  
Two-hybrid Homo sapiens
45 LRBA 987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 TMEM222 84065
Two-hybrid Homo sapiens
47 MMS22L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 PODXL 5420
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 STX8 9482
Two-hybrid Homo sapiens
50 KIR2DL4  
Affinity Capture-MS Homo sapiens
51 PPAPDC2  
Two-hybrid Homo sapiens
52 LGALS8 3964
Affinity Capture-MS Homo sapiens
53 SLC31A1 1317
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 SLC2A13 114134
Affinity Capture-MS Homo sapiens
55 ATP7A 538
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 C3orf52  
Two-hybrid Homo sapiens
57 MGST3 4259
Affinity Capture-MS Homo sapiens
58 SLC7A1 6541
Affinity Capture-MS Homo sapiens
59 TNFSF9  
Affinity Capture-MS Homo sapiens
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