Gene description for SEC14L1
Gene name SEC14-like 1 (S. cerevisiae)
Gene symbol SEC14L1
Other names/aliases PRELID4A
SEC14L
Species Homo sapiens
 Database cross references - SEC14L1
ExoCarta ExoCarta_6397
Vesiclepedia VP_6397
Entrez Gene 6397
HGNC 10698
MIM 601504
UniProt Q92503  
 SEC14L1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SEC14L1
Molecular Function
    protein binding GO:0005515 IPI
    RIG-I binding GO:0039552 IBA
    RIG-I binding GO:0039552 IPI
    protein sequestering activity GO:0140311 IDA
Biological Process
    choline transport GO:0015871 IDA
    negative regulation of RIG-I signaling pathway GO:0039536 IBA
    negative regulation of RIG-I signaling pathway GO:0039536 IMP
    innate immune response GO:0045087 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IC
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified SEC14L1 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SEC14L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDH13 1012
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 PGAM1 5223
Affinity Capture-MS Homo sapiens
4 NPTN 27020
Affinity Capture-MS Homo sapiens
5 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 KPTN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 CCNDBP1 23582
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CEP70  
Two-hybrid Homo sapiens
9 C2CD2 25966
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 LAMP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 NCR3LG1 374383
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 GPR182  
Affinity Capture-MS Homo sapiens
13 HCST  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SEC14L1 is involved
No pathways found





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